Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin
Nicole J. Mitchell, Kathy S. Xue, Shuhan Lin, Alicia Marroquin-Cardona, Kristal A. Brown, Sarah E. Elmore, Lili Tang, Amelia Romoser, Wentzel C. A. Gelderblom, Jia-Sheng Wang and Timothy D. Phillips
Article first published online: 6 NOV 2013 | DOI: 10.1002/jat.2942
The binding capacity of UPSN, a calcium montmorillonite clay, was evaluated after aflatoxin (AF) and fumonisin (FB) single and co-exposures in Fischer 344 rats. UPSN decreased AFM1 and FB1 urinary biomarker excretion by 88–97% and 45–85%, respectively. When in combination, both AFM1 and FB1 sorption occurred, but capacity was decreased by half. In the absence of UPSN, combined AFB1 and FB1 treatment decreased corresponding urinary biomarkers by 67% and 45%, respectively, but increased levels of AFB1-albumin adduct compared with AFB1-treated rats.