Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity
Petko I. Petkov, Terry W. Schultz, E. Maria Donner, Masamitsu Honma, Takeshi Morita, Shuichi Hamada, Akihiro Wakata, Masayuki Mishima, Jiro Maniwa, Milen Todorov, Elena Kaloyanova, Stefan Kotov and Ovanes G. Mekenyan
Version of Record online: 25 MAY 2016 | DOI: 10.1002/jat.3338
The performance of an integrated approach to testing and assessment (IATA) is investigated, covering different genotoxic mechanisms causing cancer and to replicate measured carcinogenicity data included in a new consolidated database. The IATA is docked to the OECD Toolbox and uses measured data for different genotoxicity endpoints when available. Alternatively, the system automatically provides predictions from structure–activity relationship genotoxicity models. When assigned only within the models' domains, performance of the IATA was high, with sensitivity of 74% and specificity of 83%.