Genotoxic risk of ethyl-paraben could be related to telomere shortening
F. Finot, A. Kaddour, L. Morat, I. Mouche, N. Zaguia, C. Cuceu, D. Souverville, S. Négrault, O. Cariou, A. Essahli, N. Prigent, J. Saul, F. Paillard, L. Heidingsfelder, P. Lafouge, M. Al Jawhari, W. M. Hempel, M. El May, B. Colicchio, A. Dieterlen, E. Jeandidier, L. Sabatier, J. Clements and R. M'Kacher
Version of Record online: 20 DEC 2016 | DOI: 10.1002/jat.3425
The impact of parabens in human breast tissue remains unclear. We demonstrated a genotoxic effect of ethyl-paraben with and without metabolic activation (S9) and a correlation between telomere dysfunction and increased genotoxic response after ethyl-paraben treatment in studies following OECD guidelines. These data demonstrate genotoxicity and a higher MN frequency of cells with telomere shortening in the presence of ethyl-paraben and could advance our knowledge on the role of paraben in breast cancer cells characterized by drastic telomere shortening.