Organ-specific distribution of gold nanoparticles by their surface functionalization
Jong Kwon Lee, Tae Sung Kim, Ji Young Bae, A. Young Jung, Sang Min Lee, Ji Hyun Seok, Hang Sik Roh, Chi Won Song, Mi Jin Choi, Jinyoung Jeong, Bong Hyun Chung, Yun-Geon Lee, Jayoung Jeong and Wan-Seob Cho
Article first published online: 28 OCT 2014 | DOI: 10.1002/jat.3075
To evaluate the role of surface charge on distribution of NPs, 15 nm-sized gold nanoparticles (AuNPs) having 3 different charges (AuNPPEG, AuNPCOOH, or AuNPNH2) were injected intravenously into mice and organ distribution were measured. The organ distribution showed the higher deposition rate depending on their functional groups: AuNPPEG for mesenteric lymph node, kidney, brain, and testis; AuNPCOOH for liver; AuNPNH2 for spleen, lung, and heart. This information is important for directing NPs or improving the kinetic properties of NPs.