The role of surface chemistry in the cytotoxicity profile of graphene
Waqar Majeed, Shawn Bourdo, Dayton M. Petibone, Viney Saini, Kieng Bao Vang, Zeid A. Nima, Karrer M. Alghazali, Emilie Darrigues, Anindya Ghosh, Fumiya Watanabe, Daniel Casciano, Syed F. Ali and Alexandru S. Biris
Version of Record online: 4 SEP 2016 | DOI: 10.1002/jat.3379
Graphene and its derivatives are an important class of nanomaterial due to their unique properties. Here, we evaluated the role of surface chemistry on the toxicological profile of the graphene structures. Pristine graphene was chemically modified to increase its level of surface oxygen to low and high oxygen content and their corresponding toxicological profile were compared. Results showed a dose-dependent trend in the cytotoxicity profile, where pristine graphene was the most cytotoxic, with decreasing toxicity observed with increasing oxygen content.