Journal of Applied Toxicology

Nanotoxicology addresses the toxicology of nanoscale particles which appear to have toxic effects that are unusual and not seen with larger particles of the same materials. In this collection of recent papers from the Journal of Applied Toxicology we focus on nanoparticles of silver, gold, titanium and carbon and their relevance in the field of medical applications, as well as their fundamental toxicity as they are extensively used in a variety of other technologies and consumer products.

This latest research is freely available here as a reference source for researchers.

Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles

Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice 

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics

Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues

Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres

Biocompatible gellan gum-reduced gold nanoparticles: cellular uptake and subacute oral toxicity studies

Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay

Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice

Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice

In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection

Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice

Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles

Short- and long-term toxicities of multi-walled carbon nanotubes in vivo and in vitro

In vivo comet assay of multi-walled carbon nanotubes using lung cells of rats intratracheally instilled

Raman spectroscopy as a detection and analysis tool for in vitro specific targeting of pancreatic cancer cells by EGF-conjugated, single-walled carbon nanotubes

Raman spectroscopy analysis and mapping the biodistribution of inhaled carbon nanotubes in the lungs and blood of mice

Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells

Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss–Webster mice 

Genotoxicity evaluation for single-walled carbon nanotubes in a battery of in vitro and in vivo assays

CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes

No evidence of the genotoxic potential of gold, silver, zinc oxide and titanium dioxide nanoparticles in the SOS chromotest

Nanotechnology and human health: risks and benefits 

ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension