Journal of Applied Toxicology

Cover image for Vol. 37 Issue 4

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)

Online ISSN: 1099-1263

Virtual Issue on Nanotoxicology


Nanotoxicology addresses the toxicology of nanoscale particles which appear to have toxic effects that are unusual and not seen with larger particles of the same materials. In this collection of recent papers from the Journal of Applied Toxicology we focus on nanoparticles of silver, gold, titanium and carbon and their relevance in the field of medical applications, as well as their fundamental toxicity as they are extensively used in a variety of other technologies and consumer products.

This latest research is freely available here as a reference source for researchers.

 Silver Nanopartilces

New articles from 2016 - Volume 36

Cytotoxicity and Apoptosis Induced by Silver Nanoparticles in Human Liver HepG2 Cells in Different Dispersion Media

Proteomic responses of human intestinal Caco-2 cells exposed to silver nanoparticles and ionic silver

Brain-targeted distribution and high retention of silver by chronic intranasal instillation of silver nanoparticles and ions in SD rats

Flow Cytometric Evaluation of the Contribution of Ionic Silver to Genotoxic Potential of Nanosilver in Human Liver HepG2 and Colon Caco2 Cells

Contribution of Ionic Silver to Genotoxic Potential of Nanosilver in Human Liver HepG2 and Colon Caco2 Cells Evaluated by Cytokinesis-block Micronucleus Assay

Silver nanoparticles induce pro-inflammatory gene expression and inflammasome activation in human monocytes

Impact of silver nanoparticles on marine diatom Skeletonema costatum

Previous volume articles

Cellular uptake and toxicity effects of silver nanoparticles in mammalian kidney cells

Different cytotoxicity responses to antimicrobial nanosilver coatings when comparing extract-based and direct-contact assays

Potential of biofluid components to modify silver nanoparticle toxicity

Comparative toxicity of silicon dioxide, silver and iron oxide nanoparticles after repeated oral administration to rats

The surfactant dipalmitoylphophatidylcholine modifies acute responses in alveolar carcinoma cells in response to low-dose silver nanoparticle exposure

Toxicogenomic responses of human liver HepG2 cells to silver nanoparticles

Analysis of cytotoxic effects of silver nanoclusters on human peripheral blood mononuclear cells ‘in vitro’

Toxic effects of colloidal nanosilver in zebrafish embryos

Interaction between silver nanoparticles of 20 nm (AgNP20) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates

Cytotoxicity and ROS production of manufactured silver nanoparticles of different sizes in hepatoma and leukemia cells

Effects of gold and silver nanoparticles in cultured human osteoarthritic chondrocytes

No evidence of the genotoxic potential of gold, silver, zinc oxide and titanium dioxide nanoparticles in the SOS chromotest

Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans

Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues

 Gold Nanoparticles

New articles from 2015 - Volume 35

Organ-specific distribution of gold nanoparticles by their surface functionalization

In vitro study of biocompatibility of a graphene composite with gold nanoparticles and hydroxyapatite on human osteoblasts

Previous volume articles

Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells

No evidence of the genotoxic potential of gold, silver, zinc oxide and titanium dioxide nanoparticles in the SOS chromotest

 Titanium Nanoparticles

New articles from 2016 - Volume 36

Quantitative evaluation of local pulmonary distribution of TiO 2 in rats following single or multiple intratracheal administrations of TiO 2 nanoparticles using X-ray fluorescence microscopy

Cytotoxic and inflammatory responses of TiO2 nanoparticles on human peripheral blood mononuclear cells

Previous volume articles

Quantitative evaluation of the pulmonary microdistribution of TiO2 nanoparticles using X-ray fluorescence microscopy after intratracheal administration with a microsprayer in rats

Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice

Biological effect of food additive titanium dioxide nanoparticles on intestine: an in vitro study

The potential health challenges of TiO2 nanomaterials

Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague–Dawley rats

Comparison of toxicity of different nanorod-type TiO2 polymorphs in vivo and in vitro

Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles

Cytotoxic, genotoxic and the hemolytic effect of titanium dioxide (TiO2) nanoparticles on human erythrocyte and lymphocyte cells in vitro

 Carbon Nanopoarticles

New articles from 2016 - Volume 36

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma following multi-walled carbon nanotube inhalation exposure in mice

Developing Xenopus Embryos Recover by Compacting and Expelling Single-Wall Carbon Nanotubes

Distribution of Single-Wall Carbon Nanotubes in the Xenopus laevis Embryo after Microinjection

Long-term retention of pristine multi-walled carbon nanotubes in rat lungs after intratracheal instillation

Previous volume articles

Distribution and biomarker of carbon-14 labeled fullerene C60 ([14C(U)]C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure

Distribution and biomarkers of carbon-14-labeled fullerene C60 ([14C(U)]C60) in female rats and mice for up to 30 days after intravenous exposure

Assessing carbon-encapsulated iron nanoparticles cytotoxicity in Lewis lung carcinoma cells

Raman spectroscopy analysis and mapping the biodistribution of inhaled carbon nanotubes in the lungs and blood of mice

In vivo comet assay of multi-walled carbon nanotubes using lung cells of rats intratracheally instilled

Preosteoblasts behavior in contact with single-walled carbon nanotubes synthesized by radio frequency induction thermal plasma using various catalysts

Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells

CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes

Zinc

New articles from 2015 - Volume 35

The toxicity and distribution of iron oxide–zinc oxide core-shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

The effect of Fe2O3 and ZnO nanoparticles on cytotoxicity and glucose metabolism in lung epithelial cells

Previous volume articles

Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation

Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions

ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension

 Other Nanoparticles

New articles from 2016 - Volume 36

In vitro cytotoxicity of superparamagnetic iron oxide nanoparticles on neuronal and glial cells. Evaluation of nanoparticle interference with viability tests.

Differentiation of Stem Cells into Insulin-Producing Cells under the Influence of Nanostructural Polyoxometalates

Zerovalent Fe, Co and Ni nanoparticle toxicity evaluated on SKOV-3 and U87 cell lines

Evaluation of uptake, cytotoxicity and inflammatory effects in respiratory cells exposed to pristine and -OH and -COOH functionalized MWCNTs

Research Advances on Potential Neurotoxicity of Quantum Dots

Distribution and immunotoxicity by intravenous injection of iron nanoparticles in a murine model

Biodistribution and toxicity of spherical aluminum oxide nanoparticles

Influence of the surface charge of PLGA nanoparticles on their in vitro genotoxicity, cytotoxicity, ROS production and endocytosis

Translocation and biokinetic behaviors of nanoscaled europium oxide particles within 5 days following an acute inhalation in rats

Copper nanoclusters triggers muscle cells apoptosis and atrophy in vitro and in vivo

Structural dependence of the In vitro cytotoxicity, oxidative stress and uptake mechanisms of Poly(propylene imine) dendritic nanoparticles.

Rhamnose-Coated Superparamagnetic Iron-Oxide Nanoparticles: An Evaluation of their in vitro cytotoxicity, genotoxicity and carcinogenicity

The Reponses of Immune Cells to Iron Oxide Nanoparticles With Various Surface Chemistries

Nanosuspension formulations of poorly water-soluble compounds for intravenous administration in exploratory toxicity studies: in vitro and in vivo evaluation

Differential cytotoxicity of copper ferrite nanopaticles in different human cells

Optimization of an air-liquid interface exposure system for assessing toxicity of airborne nanoparticles

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with pro-inflammatory activation and liver toxicity

Airborne nanoparticles (PM 0.1) induce autophagic cell death of human neuronal cells

Pluripotent stem cells:an in vitro model for nanotoxicity assessments.

Previous volume articles

Graphene supports in vitro proliferation and osteogenic differentiation of goat adult mesenchymal stem cells: potential for bone tissue engineering

Cobalt oxide nanoparticles induced oxidative stress linked to activation of TNF-α/caspase-8/p38-MAPK signaling in human leukemia cells

Comparative cytotoxicity of dolomite nanoparticles in human larynx HEp2 and liver HepG2 cells

Toxicity of cobalt–chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro

Investigation on cobalt-oxide nanoparticles cyto-genotoxicity and inflammatory response in two types of respiratory cells

Particle uptake efficiency is significantly affected by type of capping agent and cell line

Aluminium oxide nanoparticles induced morphological changes, cytotoxicity and oxidative stress in Chinook salmon (CHSE-214) cells

Intracellular calcium levels as screening tool for nanoparticle toxicity

Chromium oxide nanoparticle-induced genotoxicity and p53-dependent apoptosis in human lung alveolar cells

Difficulties in establishing regulations for engineered nanomaterials and considerations for policy makers: avoiding an unbalance between benefits and risks

Accumulation and toxicity of intravenously-injected functionalized graphene oxide in mice

Comparative effects of sulfhydryl compounds on target organellae, nuclei and mitochondria, of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes

Characterization of the components of urban particulate matter mediating impairment of nitric oxide-dependent relaxation in intrapulmonary arteries

Direct exposure at the air–liquid interface: evaluation of an in vitro approach for simulating inhalation of airborne substances

Cytotoxicity of silica nanoparticles on HaCaT cells

Evaluation of cytotoxic, oxidative stress and genotoxic responses of hydroxyapatite nanoparticles on human blood cells

Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles

Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells

Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure

Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice

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