Journal of Applied Toxicology

Cover image for Vol. 35 Issue 12

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.982

ISI Journal Citation Reports © Ranking: 2014: 27/88 (Toxicology)

Online ISSN: 1099-1263

Virtual Issue on Nanotoxicology

Nanotoxicology addresses the toxicology of nanoscale particles which appear to have toxic effects that are unusual and not seen with larger particles of the same materials. In this collection of recent papers from the Journal of Applied Toxicology we focus on nanoparticles of silver, gold, titanium and carbon and their relevance in the field of medical applications, as well as their fundamental toxicity as they are extensively used in a variety of other technologies and consumer products.

This latest research is freely available here as a reference source for researchers.

 Silver Nanopartilces

Toxic effects of colloidal nanosilver in zebrafish embryos

Interaction between silver nanoparticles of 20 nm (AgNP20) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates

Cytotoxicity and ROS production of manufactured silver nanoparticles of different sizes in hepatoma and leukemia cells

Effects of gold and silver nanoparticles in cultured human osteoarthritic chondrocytes

No evidence of the genotoxic potential of gold, silver, zinc oxide and titanium dioxide nanoparticles in the SOS chromotest

Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans

Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues

 Gold Nanoparticles

Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells

No evidence of the genotoxic potential of gold, silver, zinc oxide and titanium dioxide nanoparticles in the SOS chromotest

 Titanium Nanoparticles

Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague–Dawley rats

Comparison of toxicity of different nanorod-type TiO2 polymorphs in vivo and in vitro

Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles

Cytotoxic, genotoxic and the hemolytic effect of titanium dioxide (TiO2) nanoparticles on human erythrocyte and lymphocyte cells in vitro

 Carbon Nanopoarticles

Assessing carbon-encapsulated iron nanoparticles cytotoxicity in Lewis lung carcinoma cells

Raman spectroscopy analysis and mapping the biodistribution of inhaled carbon nanotubes in the lungs and blood of mice

In vivo comet assay of multi-walled carbon nanotubes using lung cells of rats intratracheally instilled

Preosteoblasts behavior in contact with single-walled carbon nanotubes synthesized by radio frequency induction thermal plasma using various catalysts

Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells

CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes


Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation

Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions

ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension

 Other Nanoparticles

Characterization of the components of urban particulate matter mediating impairment of nitric oxide-dependent relaxation in intrapulmonary arteries

Direct exposure at the air–liquid interface: evaluation of an in vitro approach for simulating inhalation of airborne substances

Cytotoxicity of silica nanoparticles on HaCaT cells

Evaluation of cytotoxic, oxidative stress and genotoxic responses of hydroxyapatite nanoparticles on human blood cells

Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles

Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells

Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure

Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice