Journal of Applied Toxicology
© John Wiley & Sons Ltd
Editor-in-Chief: Philip W. Harvey
Impact Factor: 2.722
ISI Journal Citation Reports © Ranking: 2015: 33/89 (Toxicology)
Online ISSN: 1099-1263
Hot Topics, Unmissable Reviews and News
Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:
Post Doc Award: Justin Conley, USEPA, USA (left)
Student Award: Parker Duffney, Rochester University, USA (right)
Recently Published Articles
- Development of an in vivo anti-androgenic activity detection assay using fenitrothion in Japanese medaka (Oryzias latipes)
Yoshifumi Horie, Haruna Watanabe, Hitomi Takanobu, Ayano Yagi, Takahiro Yamagishi, Taisen Iguchi and Norihisa Tatarazako
Version of Record online: 27 JUL 2016 | DOI: 10.1002/jat.3365
The purpose of this study was to establish a screening method for anti-androgenic activity utilizing the number of papillary processes in Japanese medaka (Oryzias latipes). After fenitrothion exposure, the number of papillary processes were significantly decreased in a dose-dependent manner in XY medaka. Our results indicate that the number of papillary processes can be used as an indicator of anti-androgenic activity and that this model may prove useful as a chemical screening method.
- Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review
Liangkai Chen, Miao Yu, Qinghua Wu, Zhao Peng, Di Wang, Kamil Kuča, Ping Yao, Hong Yan, Andreas K. Nüssler, Liegang Liu and Wei Yang
Version of Record online: 26 JUL 2016 | DOI: 10.1002/jat.3359
Three kinds of conjugated products (DON-3-glucuronide, DON-15-glucuronide and DON-7-glucuronide) can be found as major metabolites in human urine. Females and males show different patterns of exposure levels, and human exposure to DON also shows some geographical differences because of different DON levels in cereal-based foods, food intake habits and UDP-glucuronosyltransferase expression. Specifically, the C12, 13-deepoxymetabolite was found predominantly in French adults but was rarely detected in UK adults.
- Effect of 4-week inhalation exposure to 1-bromopropane on blood pressure in rats
Fen Huang, Sahoko Ichihara, Yuki Yamada, Shameema Banu and Gaku Ichihara
Version of Record online: 25 JUL 2016 | DOI: 10.1002/jat.3364
The pathophysiology of hypertension is complex and multifactorial, and includes exposure to various chemical substances. Given that 1-bromopropane (1-BP) increased reactive oxygen species in the brain of rats, we hypothesized that 1-BP also has cardiovascular toxicity through increased oxidative stress. Our results indicate that subacute (4 week) inhalation exposure to 1-BP increases blood pressure and suggest that this cardiovascular toxic effect is due, at least in part, to increased oxidative stress mediated through activation of the NADPH oxidase pathway.
- You have full text access to this OnlineOpen articleThe C. elegans model in toxicity testing
Piper Reid Hunt
Version of Record online: 22 JUL 2016 | DOI: 10.1002/jat.3357
Toxicity ranking screens in Caenorhabditis elegans have repeatedly been shown to be as predictive of rat LD50 ranking as mouse LD50 ranking. Additionally, many instances of conservation of mode of toxic action have been noted between C. elegans and mammals. These consistent correlations make the case for inclusion of C. elegans assays in early safety testing and as one component in tiered or integrated toxicity testing strategies. Good C. elegans culture practice (GCeCP) is essential for reliable results.
- Pulmonary persistence of graphene nanoplatelets may disturb physiological and immunological homeostasis
Eun-Jung Park, Sang Jin Lee, Kyuhong Lee, Young Chul Choi, Byoung-Seok Lee, Gwang-Hee Lee and Dong-Wan Kim
Version of Record online: 21 JUL 2016 | DOI: 10.1002/jat.3361
In this study, we evaluated the local and systemic health effect after pulmonary persistence of graphene nanoplatelet (GNP) (1.25, 2.5 and 5 mg kg−1). In the lung of mice exposed to the highest dose, the total number of cells and the percentage of lymphocytes significantly increased in the lung with an increase in both the number of GNP-engulfed macrophages and the percentage of apoptotic cells. A Th1-shifted immune response, the elevated chemokine secretion and the enhanced expression of cytoskeletal-related genes were observed. Additionally, the number of white blood cells (WBC) and the percentage of macrophages and neutrophils clearly increased in the blood, whereas total protein, BUN and potassium levels significantly decreased. Therefore, we suggest that pulmonary persistence of GNP may cause adverse health effects by disturbing immunological- and physiological-homeostasis of our body.