Journal of Applied Toxicology

Cover image for Vol. 37 Issue 11

Editor-in-Chief: Philip W. Harvey

Impact Factor: 3.159

ISI Journal Citation Reports © Ranking: 2016: 26/92 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2017, our congratulations go to:

Post Doc Award: Justin Conley, NHREEL, USA (left)

Student Award: Ms. Changqing Zhou, University of Illinois, USA (right)

Justin Conley SOT PhD 2017SOT 2017 Student winner Zhou

 Nanotoxicology Virtual IssueZebrafish Virtual Issue 

Parabens Virtual Issue

Recently Published Articles

  1. Cytoprotective effects of xanthohumol against methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells

    Kwang Sik Suh, Suk Chon and Eun Mi Choi

    Version of Record online: 20 SEP 2017 | DOI: 10.1002/jat.3521

    Methylglyoxal (MG) has been suggested to be a major source of intracellular reactive carbonyl compounds, and has been implicated in increasing the levels of advanced glycation end products in age-related diseases. Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. In the present study, we investigated the effects of xanthohumol on MG-induced cytotoxicity in osteoblastic MC3T3-E1 cells. Xanthohumol attenuated MG-induced cytotoxicity, as evidenced by improved cell viability, and prevented MG-induced MG-protein adducts, inflammatory cytokines, reactive oxygen species and mitochondrial superoxide production.

  2. Dermatotoxicology of sulfur mustard: Historical perspectives from World War I

    Austin Jiang and Howard Maibach

    Version of Record online: 19 SEP 2017 | DOI: 10.1002/jat.3524

    Sulfur mustard has been used as a chemical warfare agent for the past century. After its introduction by the Germans in World War I, investigators quickly began studying its impact on the human body. This review focuses on two groups in particular who conducted experiments from 1917 to 1918. These researchers anticipated multiple dermatologic phenomena including regional variation of percutaneous penetration, effect of vehicle on penetration and immunologic contact urticaria, setting the groundwork for current dermatotoxicology.

  3. Long-term exposure to bisphenol S damages the visual system and reduces the tracking capability of male zebrafish (Danio rerio)

    Wenmin Liu, Xiaona Zhang, Penghao Wei, Hua Tian, Wei Wang and Shaoguo Ru

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/jat.3519

    This study aimed to examine the effect of bisphenol S (BPS) on the visual system in male zebrafish. Zebrafish embryos were exposed to BPS at concentrations of 1, 10, 100 and 1000 μg l−1 until 120 days post-fertilization in a semi-static system. Results showed that long-term BPS exposure damaged the retinal structure, decreased their tracking capability and stimulated the transcription of opsin genes in the eyes, suggesting a severe deficiency in the visual system in male zebrafish.

  4. Effect of cadmium on kitl pre-mRNA alternative splicing in murine ovarian granulosa cells and its associated regulation by miRNAs

    Wenxiang Wang, Jie Chen, Lingfeng Luo, Yuchen Li, Jin Liu and Wenchang Zhang

    Version of Record online: 11 SEP 2017 | DOI: 10.1002/jat.3516

    Cadmium exposure affects alternative splicing of the kitl pre-mRNA in murine ovarian granulosa cells. The miRNA expression profile of murine ovarian granulosa cells after Cd exposure showed characteristic changes, and the expression of 29 miRNAs involved in alternative splicing of the kitl pre-mRNA was changed. Mmu-miR-34b-5p and mmu-miR-107-3p may be involved in alternative splicing of the kitl pre-mRNA in murine ovarian granulosa cells.

  5. Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells

    Anna Kjerstine Rosenmai, Lutz Ahrens, Théo le Godec, Johan Lundqvist and Agneta Oskarsson

    Version of Record online: 31 AUG 2017 | DOI: 10.1002/jat.3515

    The relationship between peroxisome proliferator-activated receptor alpha (PPARα) activity and cellular concentrations of perfluoroalkyl substances was investigated in HepG2 cells. PPARα activity was determined in transiently transfected cells by reporter gene assay and cellular concentrations by high-performance liquid chromatography-tandem mass spectrometry The cellular concentrations and PPARα activity of perfluoroalkyl substances was dependent on perfluorocarbon chain -length and functional group, and positive relationships between PPARα activity and cellular concentrations were established for all compounds, except perfluorooctane sulfonate and perfluorooctane sulfonamide