Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 2

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.273

ISI Journal Citation Reports © Ranking: 2014: 45/59 (Chemistry Medicinal); 54/74 (Chemistry Analytical); 67/79 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

Recently Published Issues

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Synthesis of a [18F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer

    Sandun Perera, David Piwnica-Worms and Mian M. Alauddin

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3373

    Thumbnail image of graphical abstract

    Synthesis of [18F]-fluoroethyl-ceritinib for positron emission tomography is reported. Reaction of [18F]-fluoroethyl-tosylate with ceritinib produced the product in good yield, with high purity and specific activity. The compound is a potential positron emission tomography imaging agent for the detection of anaplastic lymphoma kinase-overexpressing solid tumors such as lung cancer.

  2. A one-step automated synthesis of the dopamine transporter ligand [18F]FECNT from the chlorinated precursor

    Justyna Pijarowska-Kruszyna, Antoni Jaron, Artur Kachniarz, Bogdan Malkowski, Piotr Garnuszek and Renata Mikolajczak

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3375

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    The fluorine-18-labeled nortropane-derivative 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ([18F]FECNT) is a positron emission tomography radioligand of reference for imaging the dopamine transporter. Herein, a one-step automated synthesis of [18F]FECNT from the chlorinated precursor using the commercially available SynChrom [18F] R&D module is reported. Fluorine-18 incorporation yields were 59 ± 12% according to thin layer chromatography. The average uncorrected amount of [18F]FECNT in the final formulated dose was 2.0 ± 0.5 GBq (32 ± 7% overall decay-corrected yields) obtained with radiochemical purity over 99% and specific activity of 55 GBq/µmol.

  3. Detailed evaluation of different 68Ge/68Ga generators: an attempt toward achieving efficient 68Ga radiopharmacy

    Rubel Chakravarty, Sudipta Chakraborty, Ramu Ram, Rakhee Vatsa, Priya Bhusari, Jaya Shukla, B. R. Mittal and Ashutosh Dash

    Article first published online: 2 FEB 2016 | DOI: 10.1002/jlcr.3371

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    Gallium-68 availed from SiO2 and CeO2-PAN-based 68Ge/68Ga generators can directly be used for preparation of clinically relevant doses of 68Ga-DOTA-RGD2, while 68Ga availed from TiO2 and SnO2-based 68Ge/68Ga generators needs to be purified prior to radiolabeling procedure.

  4. Synthesis, characterization, and biological evaluation of new biotinylated 99mTc/Re-tricarbonyl complexes

    George Makris and Dionysia Papagiannopoulou

    Article first published online: 28 JAN 2016 | DOI: 10.1002/jlcr.3372

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    The synthesis and characterization of three new biotinylated fac-[99mTc/Re(CO)3]+ complexes with tridentate (N,N,O) and (N,S,O) chelators were performed. Furthermore, in vitro and in vivo evaluation of the 99mTc complexes showed that all exhibited high avidin binding affinity. In addition, 99mTcL2 and 99mTcL3 showed higher in vivo stability compared with 99mTcL1.

  5. Review: radiolabeled polymers containing covalently bound 3H and 14C (pages 38–47)

    Jeremy R. Wolf

    Article first published online: 13 JAN 2016 | DOI: 10.1002/jlcr.3359

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    Radiolabeled compounds are invaluable tools used in both academia and industry to study synthetic and biological processes. Owing to their relatively long half lives and ease of detection, tritium, and carbon-14 radiolabeled polymers find uses in mechanistic pathway elucidation, bioincorporation studies, biodegradation studies, and drug delivery applications. This literature review examines the preparation, physical properties, and applications of synthetic and biosynthetic radiolabeled polymers, which contain covalently bound tritium and carbon-14 atoms.

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