Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 60 Issue 2

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

Recently Published Issues

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Initial evaluation of 99mTc-tricarbonyl-cyclopentadienyl fatty acids derivatives as SPECT tracers for myocardium

    Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang and Huabei Zhang

    Accepted manuscript online: 9 FEB 2017 10:20PM EST | DOI: 10.1002/jlcr.3497

  2. Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms

    Martin A. Hayes, Ieuan Roberts, Gunnar Grönberg, Kexin Lv, Baorui Lin, Jonas Bergare and Charles S. Elmore

    Accepted manuscript online: 9 FEB 2017 06:01PM EST | DOI: 10.1002/jlcr.3495

  3. Preparation of clinical-scale 177Lu-Rituximab: Optimization of protocols for conjugation, radiolabeling and freeze-dried kit formulation

    Mohini Guleria, Tapas Das, Chandan Kumar, Jeyachitra Amirdhanayagam, Haladhar D. Sarma and Sharmila Banerjee

    Accepted manuscript online: 8 FEB 2017 10:20PM EST | DOI: 10.1002/jlcr.3493

  4. 99mTc-tazobactam a novel infection imaging agent: Radiosynthesis, quality control, biodistribution and infection imaging studies

    Rashid Rasheed, Syed Ali Raza Naqvi, Syed Jawad Hussain Gillani, Ameer Fawad Zahoor, Asif jielani and Nidda Saeed

    Accepted manuscript online: 8 FEB 2017 09:45PM EST | DOI: 10.1002/jlcr.3494

  5. Enantiospecific tritium labeling of 28-homocastasterone

    Tomáš Elbert, Mahadeo R. Patil and Aleš Marek

    Version of Record online: 3 FEB 2017 | DOI: 10.1002/jlcr.3488

    Thumbnail image of graphical abstract

    The 6-step synthetic sequence starting from the brassinosteroid to be labeled provides the desired tritium stereospecifically and regiospecifically labeled brassinosteroids in satisfactory yields and with radiochemical purities >97% as required for biological experiments. This paper describes the synthesis of 28-[3β-3H]homocastasterone with a high SA of 5.8 Ci/mmol as a proof-of-concept of this new methodology.

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