Journal of Labelled Compounds and Radiopharmaceuticals
© John Wiley & Sons Ltd
Editors-in-Chief: R F Dannals and K M W Lawrie
Impact Factor: 1.532
ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)
Online ISSN: 1099-1344
Young Scientists Award
Congratulations to the 2015 Young Scientists JLCR Awardees
From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules
Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes
Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles
Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis
Recently Published Articles
- Adding value through accelerator mass spectrometry-enabled first in human studies
Mark A. Seymour
Version of Record online: 22 JUL 2016 | DOI: 10.1002/jlcr.3420
Accelerator mass spectrometry can be used to enhance the design of first in human clinical studies and generate significant additional data, including intravenous pharmacokinetics, absolute bioavailability, mass balance, excretion, metabolic fate and tissue disposition. The approach requires relatively little additional expense and can save significant time compared with conventional approaches.
- 177Lu-5-Fluorouracil a potential theranostic radiopharmaceutical: radiosynthesis, quality control, biodistribution, and scintigraphy
Rashid Rasheed, Saleha Tariq, Syed Ali Raza Naqvi, Syed Jawad Hussain Gillani, Faheem Askari Rizvi, Muhammad Sajid and Shahid Rasheed
Version of Record online: 22 JUL 2016 | DOI: 10.1002/jlcr.3423
5-Flourouracil (5-FU) is widely accepted as an anti-cancer chemotherapeutic drug of broad spectrum fame. The labeling of 5-FU was carried out using β-rays emitter radionuclide (lutetium-177) to develop therapeutic radiopharmaceuticals.
- Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia
Evelyn Laurens, Shinn Dee Yeoh, Angela Rigopoulos, Graeme J. O'Keefe, Henri J. Tochon-Danguy, Lee Wenn Chong, Jonathan M. White, Andrew M. Scott and Uwe Ackermann
Version of Record online: 19 JUL 2016 | DOI: 10.1002/jlcr.3426
A new nitrophenyl sulfoxide for imaging hypoxia was synthesized via halogen exchange in non-decay corrected yields of radioactivity of 1.18 ± 0.24%. The radiotracer was investigated in our well-established SK-RC-52 model of tumor hypoxia and its pharmacokinetics compared with [18F]FMISO. The fast clearance of [18F]1 from normoxic tissue allows for imaging at earlier timepoints than [18F]FMISO. This compound is an interesting lead structure for further development of hypoxia tracers.
- Synthesis and quality control of [18F]T807 for tau PET imaging
Daniel P. Holt, Hayden T. Ravert and Robert F. Dannals
Version of Record online: 17 JUL 2016 | DOI: 10.1002/jlcr.3425
The detailed synthesis and quality control of [18F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/μmole (120 Ci/μmole) and an average radiochemical yield of 32%. Compliance with all standard USP Chapter <823> acceptance tests was observed.
- Evaluation of C18 monolithic columns for radiochemical purity measurement
David J. Schenk, Christopher J. Welch and Vincent Antonucci
Version of Record online: 13 JUL 2016 | DOI: 10.1002/jlcr.3422
The performance of a C18 monolithic column was evaluated by comparing its radiochemical results with those from a traditional 25-cm C18 column. Most results were similar for the 54 compounds assayed, but a few cases with large differences (>1%) were found. A confidence of ~85% was calculated for the 15-min monolithic method's ability to reproduce the conventional column result.