Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 13

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees


From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Synthesis of C-14 radiolabeled glucagon receptor antagonist and its use in a human mass balance study

    Boris A. Czeskis and Darlene K. Satonin

    Version of Record online: 1 DEC 2016 | DOI: 10.1002/jlcr.3477

    Thumbnail image of graphical abstract

    The synthesis of the radiolabeled glucagon receptor antagonist 1-[14C] was accomplished based on decarboxylative iodination of acid 2 followed by “reattachment” of 14C carboxylic function to form 2-[14C]. Coupling with β-alanine fragment completed the synthesis of the target molecule. The resulting compound was utilized in a mass balance and metabolism study.

  2. A simple method for preparation of pure 68Ga-acetate precursor for formulation of radiopharmaceuticals: Physicochemical characteristics of the 68Ga eluate of the SnO2 based-68Ge/68Ga column generator

    Sankha Chattopadhyay, Md. Neyar Alam, Madhu Smita, Umesh Kumar, Sujata Saha Das and Luna Barua

    Version of Record online: 1 DEC 2016 | DOI: 10.1002/jlcr.3475

    Thumbnail image of graphical abstract

    A simple sodium hydroxide (NaOH)-based 68Ga eluate concentration method that enables rapid conversion of 68Ga-chloride into 68Ga-acetate form, a precursor for preparation of various types of radiopharmaceuticals, is described. The 68Ga generator eluate is collected by use of a strong cation-exchange resin column (Dowex-50), and about 84% of the total activity of 68Ga is eluted from the column with 1N NaOH solution. This method is well suited for routine-automated synthesis of clinical radiopharmaceuticals.

  3. Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A

    Sally Wagner, Rodrigo Teodoro, Winnie Deuther-Conrad, Mathias Kranz, Matthias Scheunemann, Steffen Fischer, Barbara Wenzel, Ute Egerland, Norbert Hoefgen, Jörg Steinbach and Peter Brust

    Version of Record online: 29 NOV 2016 | DOI: 10.1002/jlcr.3471

    Thumbnail image of graphical abstract

    A fully automated radiosynthesis of [18F]AQ28A was achieved starting from the nitro precursor AQ63. In vitro autoradiography demonstrated the suitability of [18F]AQ28A as a specific radioligand to visualize the PDE10A protein in different species. Animal PET revealed a specific accumulation of [18F]AQ28A in the PDE10A-rich striatum, along with a lack of specific accumulation after blocking PDE10A with MP-10.

  4. Synthesis of unlabelled and stable isotope labelled glucuronide metabolites of dapagliflozin and synthesis of stable isotope labelled dapagliflozin

    Kai Cao, John A. Brailsford, Ming Yao, Janet Caceres-Cortes, Robert Espina and Samuel J. Bonacorsi Jr

    Accepted manuscript online: 21 NOV 2016 12:55AM EST | DOI: 10.1002/jlcr.3484

  5. The synthesis of a tritium, carbon-14 and stable isotope labelled cathepsin C inhibitors

    Paul Allen, Ryan A. Bragg, Moya Caffrey, Cecilia Ericsson, Michael J. Hickey, Lee P. Kingston and Charles S. Elmore

    Accepted manuscript online: 21 NOV 2016 12:30AM EST | DOI: 10.1002/jlcr.3483