Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 2

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.273

ISI Journal Citation Reports © Ranking: 2014: 45/59 (Chemistry Medicinal); 54/74 (Chemistry Analytical); 67/79 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees


From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Radiosynthesis and preliminary biological evaluation of a new 18F-labeled triethylene glycol derivative of triphenylphosphonium

    Takahiro Tominaga, Hiroaki Ito, Yoichi Ishikawa, Ren Iwata, Kiichi Ishiwata and Shozo Furumoto

    Article first published online: 10 FEB 2016 | DOI: 10.1002/jlcr.3379

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    A 18F-PEGylated derivative of benzyltriphenylphosphonium ([18F]FPEGBnTP) was synthesized through the reaction of the 18F-PEGylated benzyl alcohol intermediate with triphenylphosphine hydrobromide. [18F]FPEGBnTP showed higher accumulation in the heart than the organs near the heart.

  2. Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging

    Dae-Weung Kim, Myoung Hyoun Kim and Chang Guhn Kim

    Article first published online: 9 FEB 2016 | DOI: 10.1002/jlcr.3378

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    In the present study, Tc-99m ECG-HGK was developed as a novel Tc-99m agent for tumor imaging. Tc-99m ECG-HGK showed a substantial uptake in the HT-1080 tumor, and it is a good candidate for tumor imaging.

  3. Synthesis of a [18F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer

    Sandun Perera, David Piwnica-Worms and Mian M. Alauddin

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3373

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    Synthesis of [18F]-fluoroethyl-ceritinib for positron emission tomography is reported. Reaction of [18F]-fluoroethyl-tosylate with ceritinib produced the product in good yield, with high purity and specific activity. The compound is a potential positron emission tomography imaging agent for the detection of anaplastic lymphoma kinase-overexpressing solid tumors such as lung cancer.

  4. A one-step automated synthesis of the dopamine transporter ligand [18F]FECNT from the chlorinated precursor

    Justyna Pijarowska-Kruszyna, Antoni Jaron, Artur Kachniarz, Bogdan Malkowski, Piotr Garnuszek and Renata Mikolajczak

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3375

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    The fluorine-18-labeled nortropane-derivative 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ([18F]FECNT) is a positron emission tomography radioligand of reference for imaging the dopamine transporter. Herein, a one-step automated synthesis of [18F]FECNT from the chlorinated precursor using the commercially available SynChrom [18F] R&D module is reported. Fluorine-18 incorporation yields were 59 ± 12% according to thin layer chromatography. The average uncorrected amount of [18F]FECNT in the final formulated dose was 2.0 ± 0.5 GBq (32 ± 7% overall decay-corrected yields) obtained with radiochemical purity over 99% and specific activity of 55 GBq/µmol.

  5. Detailed evaluation of different 68Ge/68Ga generators: an attempt toward achieving efficient 68Ga radiopharmacy

    Rubel Chakravarty, Sudipta Chakraborty, Ramu Ram, Rakhee Vatsa, Priya Bhusari, Jaya Shukla, B. R. Mittal and Ashutosh Dash

    Article first published online: 2 FEB 2016 | DOI: 10.1002/jlcr.3371

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    Gallium-68 availed from SiO2 and CeO2-PAN-based 68Ge/68Ga generators can directly be used for preparation of clinically relevant doses of 68Ga-DOTA-RGD2, while 68Ga availed from TiO2 and SnO2-based 68Ge/68Ga generators needs to be purified prior to radiolabeling procedure.