Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 60 Issue 2

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

Recently Published Issues

See all

Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees


From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Initial evaluation of 99mTc-tricarbonyl-cyclopentadienyl fatty acids derivatives as SPECT tracers for myocardium

    Jianping Liu, Huan Wang, Shuxia Wang, Qianqian Xue, Dawei Wang, Wang Hang and Huabei Zhang

    Accepted manuscript online: 9 FEB 2017 10:20PM EST | DOI: 10.1002/jlcr.3497

  2. Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms

    Martin A. Hayes, Ieuan Roberts, Gunnar Grönberg, Kexin Lv, Baorui Lin, Jonas Bergare and Charles S. Elmore

    Accepted manuscript online: 9 FEB 2017 06:01PM EST | DOI: 10.1002/jlcr.3495

  3. Preparation of clinical-scale 177Lu-Rituximab: Optimization of protocols for conjugation, radiolabeling and freeze-dried kit formulation

    Mohini Guleria, Tapas Das, Chandan Kumar, Jeyachitra Amirdhanayagam, Haladhar D. Sarma and Sharmila Banerjee

    Accepted manuscript online: 8 FEB 2017 10:20PM EST | DOI: 10.1002/jlcr.3493

  4. 99mTc-tazobactam a novel infection imaging agent: Radiosynthesis, quality control, biodistribution and infection imaging studies

    Rashid Rasheed, Syed Ali Raza Naqvi, Syed Jawad Hussain Gillani, Ameer Fawad Zahoor, Asif jielani and Nidda Saeed

    Accepted manuscript online: 8 FEB 2017 09:45PM EST | DOI: 10.1002/jlcr.3494

  5. Enantiospecific tritium labeling of 28-homocastasterone

    Tomáš Elbert, Mahadeo R. Patil and Aleš Marek

    Version of Record online: 3 FEB 2017 | DOI: 10.1002/jlcr.3488

    Thumbnail image of graphical abstract

    The 6-step synthetic sequence starting from the brassinosteroid to be labeled provides the desired tritium stereospecifically and regiospecifically labeled brassinosteroids in satisfactory yields and with radiochemical purities >97% as required for biological experiments. This paper describes the synthesis of 28-[3β-3H]homocastasterone with a high SA of 5.8 Ci/mmol as a proof-of-concept of this new methodology.