Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 60 Issue 3

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

Recently Published Issues

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. cGMP production of the radiopharmaceutical [18F]MK-6240 for PET imaging of human neurofibrillary tangles

    Thomas Lee Collier, Daniel L. Yokell, Eli Livni, Peter A. Rice, Sofie Celen, Kim Serdons, Ramesh Neelamegam, Guy Bormans, Dawn Harris, Abbas Walji, Eric D. Hostetler, Idriss Bennacef and Neil Vasdev

    Version of Record online: 23 MAR 2017 | DOI: 10.1002/jlcr.3496

    Thumbnail image of graphical abstract

    The fully automated 2-step radiosynthesis of the tau PET imaging agent, fluorine-18 labelled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK-6240), was validated for human use using a commercially available radiosynthesis module.

  2. Preparation of clinical-scale 177Lu-Rituximab: Optimization of protocols for conjugation, radiolabeling, and freeze-dried kit formulation

    Mohini Guleria, Tapas Das, Chandan Kumar, Jeyachitra Amirdhanayagam, Haladhar D. Sarma and Sharmila Banerjee

    Version of Record online: 23 MAR 2017 | DOI: 10.1002/jlcr.3493

    Thumbnail image of graphical abstract

    Methodology for the formulation of clinical-scale 177Lu-Rituximab using the freeze-dried Rituximab kit, developed in-house, has been described. Biological efficacy of the radiolabeled agent has been studied by in vivo pharmacokinetic evaluation and in vitro cell binding studies.

  3. Synthesis of Two C-14 labeled Cathepsin C Inhibitors; the Use of a Cyanide to Displace a Benzotriazole

    Lee Kingston, Jonas Bergare, Hans Lönn, Cecilia Ericsson, Gunnar Grönberg, Song Chen and Charles S. Elmore

    Accepted manuscript online: 21 MAR 2017 06:20PM EST | DOI: 10.1002/jlcr.3502

  4. Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms

    Martin A. Hayes, Ieuan Roberts, Gunnar Grönberg, Kexin Lv, Baorui Lin, Jonas Bergare and Charles S. Elmore

    Version of Record online: 20 MAR 2017 | DOI: 10.1002/jlcr.3495

    Thumbnail image of graphical abstract

    A multistep synthesis of 1-hydroxy deoxycholic acid and a D4-labeled version were initiated. After difficulties were encountered, a biocatalyzed approach was also investigated and was found to be much more rapid and efficient for the small-scale manufacture of the target compounds.

  5. Development of a novel, fibrin-specific PET tracer

    Tiemen van Mourik, Michael Claesener, Klaas Nicolay and Holger Gruell

    Accepted manuscript online: 20 MAR 2017 01:10AM EST | DOI: 10.1002/jlcr.3501

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