Journal of Labelled Compounds and Radiopharmaceuticals
© John Wiley & Sons Ltd
Editors-in-Chief: R F Dannals and K M W Lawrie
Impact Factor: 1.273
ISI Journal Citation Reports © Ranking: 2014: 45/59 (Chemistry Medicinal); 54/74 (Chemistry Analytical); 67/79 (BIOCHEMICAL RESEARCH METHODS)
Online ISSN: 1099-1344
Young Scientists Award
Congratulations to the 2015 Young Scientists JLCR Awardees
From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules
Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes
Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles
Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis
Recently Published Articles
- Radiosynthesis and preliminary biological evaluation of a new 18F-labeled triethylene glycol derivative of triphenylphosphonium
Takahiro Tominaga, Hiroaki Ito, Yoichi Ishikawa, Ren Iwata, Kiichi Ishiwata and Shozo Furumoto
Article first published online: 10 FEB 2016 | DOI: 10.1002/jlcr.3379
A 18F-PEGylated derivative of benzyltriphenylphosphonium ([18F]FPEGBnTP) was synthesized through the reaction of the 18F-PEGylated benzyl alcohol intermediate with triphenylphosphine hydrobromide. [18F]FPEGBnTP showed higher accumulation in the heart than the organs near the heart.
- Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging
Dae-Weung Kim, Myoung Hyoun Kim and Chang Guhn Kim
Article first published online: 9 FEB 2016 | DOI: 10.1002/jlcr.3378
In the present study, Tc-99m ECG-HGK was developed as a novel Tc-99m agent for tumor imaging. Tc-99m ECG-HGK showed a substantial uptake in the HT-1080 tumor, and it is a good candidate for tumor imaging.
- Synthesis of a [18F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer
Sandun Perera, David Piwnica-Worms and Mian M. Alauddin
Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3373
Synthesis of [18F]-fluoroethyl-ceritinib for positron emission tomography is reported. Reaction of [18F]-fluoroethyl-tosylate with ceritinib produced the product in good yield, with high purity and specific activity. The compound is a potential positron emission tomography imaging agent for the detection of anaplastic lymphoma kinase-overexpressing solid tumors such as lung cancer.
- A one-step automated synthesis of the dopamine transporter ligand [18F]FECNT from the chlorinated precursor
Justyna Pijarowska-Kruszyna, Antoni Jaron, Artur Kachniarz, Bogdan Malkowski, Piotr Garnuszek and Renata Mikolajczak
Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3375
The fluorine-18-labeled nortropane-derivative 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ([18F]FECNT) is a positron emission tomography radioligand of reference for imaging the dopamine transporter. Herein, a one-step automated synthesis of [18F]FECNT from the chlorinated precursor using the commercially available SynChrom [18F] R&D module is reported. Fluorine-18 incorporation yields were 59 ± 12% according to thin layer chromatography. The average uncorrected amount of [18F]FECNT in the final formulated dose was 2.0 ± 0.5 GBq (32 ± 7% overall decay-corrected yields) obtained with radiochemical purity over 99% and specific activity of 55 GBq/µmol.
- Detailed evaluation of different 68Ge/68Ga generators: an attempt toward achieving efficient 68Ga radiopharmacy
Rubel Chakravarty, Sudipta Chakraborty, Ramu Ram, Rakhee Vatsa, Priya Bhusari, Jaya Shukla, B. R. Mittal and Ashutosh Dash
Article first published online: 2 FEB 2016 | DOI: 10.1002/jlcr.3371
Gallium-68 availed from SiO2 and CeO2-PAN-based 68Ge/68Ga generators can directly be used for preparation of clinically relevant doses of 68Ga-DOTA-RGD2, while 68Ga availed from TiO2 and SnO2-based 68Ge/68Ga generators needs to be purified prior to radiolabeling procedure.