Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 2

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.273

ISI Journal Citation Reports © Ranking: 2014: 45/59 (Chemistry Medicinal); 54/74 (Chemistry Analytical); 67/79 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

Recently Published Issues

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Radiosynthesis and preliminary biological evaluation of a new 18F-labeled triethylene glycol derivative of triphenylphosphonium

    Takahiro Tominaga, Hiroaki Ito, Yoichi Ishikawa, Ren Iwata, Kiichi Ishiwata and Shozo Furumoto

    Article first published online: 10 FEB 2016 | DOI: 10.1002/jlcr.3379

    Thumbnail image of graphical abstract

    A 18F-PEGylated derivative of benzyltriphenylphosphonium ([18F]FPEGBnTP) was synthesized through the reaction of the 18F-PEGylated benzyl alcohol intermediate with triphenylphosphine hydrobromide. [18F]FPEGBnTP showed higher accumulation in the heart than the organs near the heart.

  2. Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging

    Dae-Weung Kim, Myoung Hyoun Kim and Chang Guhn Kim

    Article first published online: 9 FEB 2016 | DOI: 10.1002/jlcr.3378

    Thumbnail image of graphical abstract

    In the present study, Tc-99m ECG-HGK was developed as a novel Tc-99m agent for tumor imaging. Tc-99m ECG-HGK showed a substantial uptake in the HT-1080 tumor, and it is a good candidate for tumor imaging.

  3. Synthesis of a [18F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer

    Sandun Perera, David Piwnica-Worms and Mian M. Alauddin

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3373

    Thumbnail image of graphical abstract

    Synthesis of [18F]-fluoroethyl-ceritinib for positron emission tomography is reported. Reaction of [18F]-fluoroethyl-tosylate with ceritinib produced the product in good yield, with high purity and specific activity. The compound is a potential positron emission tomography imaging agent for the detection of anaplastic lymphoma kinase-overexpressing solid tumors such as lung cancer.

  4. A one-step automated synthesis of the dopamine transporter ligand [18F]FECNT from the chlorinated precursor

    Justyna Pijarowska-Kruszyna, Antoni Jaron, Artur Kachniarz, Bogdan Malkowski, Piotr Garnuszek and Renata Mikolajczak

    Article first published online: 8 FEB 2016 | DOI: 10.1002/jlcr.3375

    Thumbnail image of graphical abstract

    The fluorine-18-labeled nortropane-derivative 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ([18F]FECNT) is a positron emission tomography radioligand of reference for imaging the dopamine transporter. Herein, a one-step automated synthesis of [18F]FECNT from the chlorinated precursor using the commercially available SynChrom [18F] R&D module is reported. Fluorine-18 incorporation yields were 59 ± 12% according to thin layer chromatography. The average uncorrected amount of [18F]FECNT in the final formulated dose was 2.0 ± 0.5 GBq (32 ± 7% overall decay-corrected yields) obtained with radiochemical purity over 99% and specific activity of 55 GBq/µmol.

  5. Detailed evaluation of different 68Ge/68Ga generators: an attempt toward achieving efficient 68Ga radiopharmacy

    Rubel Chakravarty, Sudipta Chakraborty, Ramu Ram, Rakhee Vatsa, Priya Bhusari, Jaya Shukla, B. R. Mittal and Ashutosh Dash

    Article first published online: 2 FEB 2016 | DOI: 10.1002/jlcr.3371

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    Gallium-68 availed from SiO2 and CeO2-PAN-based 68Ge/68Ga generators can directly be used for preparation of clinically relevant doses of 68Ga-DOTA-RGD2, while 68Ga availed from TiO2 and SnO2-based 68Ge/68Ga generators needs to be purified prior to radiolabeling procedure.

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