Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 13

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Synthesis of C-14 radiolabeled glucagon receptor antagonist and its use in a human mass balance study

    Boris A. Czeskis and Darlene K. Satonin

    Version of Record online: 1 DEC 2016 | DOI: 10.1002/jlcr.3477

    Thumbnail image of graphical abstract

    The synthesis of the radiolabeled glucagon receptor antagonist 1-[14C] was accomplished based on decarboxylative iodination of acid 2 followed by “reattachment” of 14C carboxylic function to form 2-[14C]. Coupling with β-alanine fragment completed the synthesis of the target molecule. The resulting compound was utilized in a mass balance and metabolism study.

  2. A simple method for preparation of pure 68Ga-acetate precursor for formulation of radiopharmaceuticals: Physicochemical characteristics of the 68Ga eluate of the SnO2 based-68Ge/68Ga column generator

    Sankha Chattopadhyay, Md. Neyar Alam, Madhu Smita, Umesh Kumar, Sujata Saha Das and Luna Barua

    Version of Record online: 1 DEC 2016 | DOI: 10.1002/jlcr.3475

    Thumbnail image of graphical abstract

    A simple sodium hydroxide (NaOH)-based 68Ga eluate concentration method that enables rapid conversion of 68Ga-chloride into 68Ga-acetate form, a precursor for preparation of various types of radiopharmaceuticals, is described. The 68Ga generator eluate is collected by use of a strong cation-exchange resin column (Dowex-50), and about 84% of the total activity of 68Ga is eluted from the column with 1N NaOH solution. This method is well suited for routine-automated synthesis of clinical radiopharmaceuticals.

  3. Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A

    Sally Wagner, Rodrigo Teodoro, Winnie Deuther-Conrad, Mathias Kranz, Matthias Scheunemann, Steffen Fischer, Barbara Wenzel, Ute Egerland, Norbert Hoefgen, Jörg Steinbach and Peter Brust

    Version of Record online: 29 NOV 2016 | DOI: 10.1002/jlcr.3471

    Thumbnail image of graphical abstract

    A fully automated radiosynthesis of [18F]AQ28A was achieved starting from the nitro precursor AQ63. In vitro autoradiography demonstrated the suitability of [18F]AQ28A as a specific radioligand to visualize the PDE10A protein in different species. Animal PET revealed a specific accumulation of [18F]AQ28A in the PDE10A-rich striatum, along with a lack of specific accumulation after blocking PDE10A with MP-10.

  4. Synthesis of unlabelled and stable isotope labelled glucuronide metabolites of dapagliflozin and synthesis of stable isotope labelled dapagliflozin

    Kai Cao, John A. Brailsford, Ming Yao, Janet Caceres-Cortes, Robert Espina and Samuel J. Bonacorsi Jr

    Accepted manuscript online: 21 NOV 2016 12:55AM EST | DOI: 10.1002/jlcr.3484

  5. The synthesis of a tritium, carbon-14 and stable isotope labelled cathepsin C inhibitors

    Paul Allen, Ryan A. Bragg, Moya Caffrey, Cecilia Ericsson, Michael J. Hickey, Lee P. Kingston and Charles S. Elmore

    Accepted manuscript online: 21 NOV 2016 12:30AM EST | DOI: 10.1002/jlcr.3483

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