Journal of Labelled Compounds and Radiopharmaceuticals
© John Wiley & Sons Ltd
Editors-in-Chief: R F Dannals and K M W Lawrie
Impact Factor: 1.532
ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)
Online ISSN: 1099-1344
Young Scientists Award
Congratulations to the 2015 Young Scientists JLCR Awardees
From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules
Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes
Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles
Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis
Recently Published Articles
- Efficient synthesis of D6-clenproperol and D6-cimaterol using deuterium isopropylamine as labelled precursor
Kai Sun, Chao Fang, Weicheng Yang, Zhongjie Xu, Haoran Wang, Wen Sun, Yong Luo and Yi Xu
Version of Record online: 17 OCT 2016 | DOI: 10.1002/jlcr.3447
An efficient synthesis of D6-clenproperol and D6-cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor.
- Buscopan labeled with carbon-14 and deuterium
Bachir Latli, Michael Stiasni, Matt Hrapchak, Zhibin Li, Nelu Grinberg, Heewon Lee, Carl A. Busacca and Chris H. Senanayake
Version of Record online: 17 OCT 2016 | DOI: 10.1002/jlcr.3463
A straightforward synthesis of carbon-14 and deuterium-labeled Buscopan was developed using scopolamine, n-butyl-1-14C bromide, and n-butyl-2H9 bromide, respectively. In a second carbon-14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety. The detailed preparations of carbon-14 and deuterium-labeled Buscopan are reported.
- High specific activity is not optimal: 18F-fluoroestradio positron emission tomography-computed tomography results in a breast cancer xenograft
Zhongyi Yang, Huiyu Yuan, Xiaoping Xu, Bingxin Gu, Mingwei Wang, Jianping Zhang, Yongping Zhang and Yingjian Zhang
Version of Record online: 13 OCT 2016 | DOI: 10.1002/jlcr.3467
High SA of 18F-FES lead to low T/M results in breast cancer xenograft models. The blood levels of estradiol and SHBG showed no correlation with the value of T/M (P > 0.05). We should control SA of 18F-FES in a reasonable range in order to obtain high quality images.
- Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol
Yahui Tu, Jiaqi Zhong, Haoran Wang, Jie Pan, Zhongjie Xu, Weicheng Yang and Yong Luo
Version of Record online: 13 OCT 2016 | DOI: 10.1002/jlcr.3446
Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity.
- Radiosynthesis of novel pitavastatin derivative ([18F]PTV-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure
Hiroyuki Kimura, Yusuke Yagi, Kenji Arimitsu, Kazuya Maeda, Kazuaki Ikejiri, Jun-ichi Takano, Hiroyuki Kusuhara, Shinya Kagawa, Masahiro Ono, Yuichi Sugiyama and Hideo Saji
Version of Record online: 2 OCT 2016 | DOI: 10.1002/jlcr.3464
Hepatic organic anion transporting polypeptide 1B1 (OATP1B1) is a multispecific transporter expressed in the liver that plays an important role in the metabolism of drugs associated with the hepatobiliary transport of anionic drugs. Because OATP1B1 leads to variation of the drug effect, it is important to evaluate the OATP1B1 function for prediction of therapeutic efficacy. For the development of in vivo evaluation of OATP1B1 function by positron emission tomography, we designed and synthesized a novel [18F]pitavastatin derivative ([18F]PTV-F1).