Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 58 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.273

ISI Journal Citation Reports © Ranking: 2014: 45/59 (Chemistry Medicinal); 54/74 (Chemistry Analytical); 67/79 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

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  1. Research Articles

    1. Synthesis and bioevaluation of 4-chloro-2-tert-butyl-5-[2-[[1-[2-[18F]fluroethyl]-1H-1,2,3-triazol-4-yl]methyl]phenylmethoxy]-3(2H)-pyridazinone as potential myocardial perfusion imaging agent with PET

      Tiantian Mou, Zuoquan Zhao, Linyi You, Qian Wang, Wei Fang, Jie Lu, Cheng Peng and Xianzhong Zhang

      Article first published online: 22 JUN 2015 | DOI: 10.1002/jlcr.3310

      Thumbnail image of graphical abstract

      4-chloro-2-tert-butyl-5-[2-[[1-[2-[18F]fluroethyl]-1H-1,2,3-triazol-4-yl]methyl]phenylmethoxy]-3(2H)-pyridazinone ([18F]Fmp2) was synthesized and characterized as potential myocardial perfusion imaging agent with improved stability, high heart uptake, and good target/non-target ratio in PET imaging of Chinese mini-swine.

    2. Development of 153Sm-folate-polyethyleneimine-conjugated chitosan nanoparticles for targeted therapy

      Esmail Mollarazi, Amir R. Jalilian, Fariba Johari-daha and Fatemeh Atyabi

      Article first published online: 2 JUN 2015 | DOI: 10.1002/jlcr.3305

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      153Sm-CHI-DTPA-g-PEI-FA nanoparticles were prepared in >90% radiochemical purity demonstrating folate receptor specific binding in MCF-7 cells and major renal excretion. The imaging studies in 4T1 tumor-bearing mice demonstrated detectable uptake.

    3. Simple preparation of new [18F]F-labeled synthetic amino acid derivatives with two click reactions in one-pot and SPE purification

      Cheol-Min Yook, Sang Ju Lee, Seung Jun Oh, Hyun-Joon Ha and Jong Jin Lee

      Article first published online: 1 JUN 2015 | DOI: 10.1002/jlcr.3297

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      New [18F]fluorinated 1,2,3-triazolyl amino acid derivatives were efficiently prepared from one-pot and two simultaneous click chemistry with simple solid-phase extraction purification. Our new method involving two click reactions in one-pot showed high radiochemical and chemical purity by easy removal of the unused precursor from the simultaneous two click reactions.

    4. Technetium-99 m labeling and evaluation of olsalazine: a novel agent for ulcerative colitis imaging

      O. A. El-Kawy, I. T. Ibrahim and K. Farah

      Article first published online: 1 JUN 2015 | DOI: 10.1002/jlcr.3306

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      In the current investigation, radio complexation of olsalazine with technetium-99m, its characterization and optimization of the labeling conditions were explored. The computer-generated optimized geometries of the 99mTc-olsalazine were reported, and biodistribution studies were carried out using chemically and microbiologically mice-induced ulcerative colitis models. All the gathered data supported the usefulness of 99mTc-olsalazine as a potential imaging agent for ulcerative colitis.

    5. Improved synthesis and application of [11C]benzyl iodide in positron emission tomography radiotracer production

      Aleksandra Pekošak, Ulrike Filp, Lonneke Rotteveel, Alex J. Poot and Albert D. Windhorst

      Article first published online: 29 MAY 2015 | DOI: 10.1002/jlcr.3307

      Thumbnail image of graphical abstract

      The synthesis of [11C]benzyl iodide was investigated and significantly improved and automated. It was applied for labeling of the dopamine D2 antagonist [11C]clebopride to prove its value as a carbon-11 labeling reagent. [11C]Benzyl iodide was synthesized in 11 min from [11C]CO2, according to a one-pot procedure with high yield, purity, and specific activity. This reliable synthesis of [11C]benzyl iodide allows for its broad application in positron emission tomography radiopharmaceutical development.

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