Journal of Labelled Compounds and Radiopharmaceuticals

Author Guidelines

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Author Guidelines

• General
• Manuscript Submission
• Copyright and Permissions
• Pre- Submission English Editing
• Presentation of Papers
• Writing Abstracts
• Nomenclature, Abbreviations and Symbols
• Reference Style
• Illustrations and ChemDraw Rules
• Graphical Table of Contents
• Colour Policy
• Citing EarlyView Articles
• Supporting Information
• Ethical Treatment of Humans and Animals
• Article Formats Published in JLCR
• Further Information

General

Journal of Labelled Compounds and Radiopharmaceuticals (JLCR) publishes original scientific manuscripts and reviews dealing with all aspects of research and development leading to and resulting in labelled compound preparation. Related areas such as analytical control, self radiolysis, quality control handling and storage, are also covered. Papers on compounds and tracer methods used in chemical, biochemical, biological, pharmacological, medical, genetic, agricultural and geochemical research and application also appear. All radionuclides and enriched stable nuclides are included.

A partial list of topics includes:

• Radionuclide production.
• Cyclotron targetry.
• Neutron irradiation methodology.
• Precursor preparation and production.
• Synthesis (chemical, biochemical, radiation, isotope exchange, etc).
• Automation of nuclide production, precursor, preparation and synthesis.
• Analysis (methods, limitations, etc. for both radioactive and stable nuclides, including new detection techniques).
• Quality control (an essential requirement for valid data and especially for radiopharmaceuticals).
• Self radiolysis, stability and storage problems.
• Special problems relating to production and handling of Curie and multiCurie amounts of radioactivity.
• Theory and practice relating to carrier problems, `isotope' dilution, and other factors concerning stable nuclide and radionuclide use.

Manuscripts on applications are welcome where the focus is primarily on the preparation, or special aspects of use, of the labelled compound.

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Manuscript Submission

All papers must be submitted via the online system. Journal of Labelled Compounds and Radiopharmaceuticals operates an online submission and peer review system that allows authors to submit articles online and track their progress via a web interface. Please read the remainder of these instructions to authors and then click http://mc.manuscriptcentral.com/jlcr to navigate to the Journal of Labelled Compounds and Radiopharmaceuticals online submission site.

IMPORTANT: Please check whether you already have an account in the system before trying to create a new one. If you have reviewed or authored for the journal in the past year it is likely that you will have created an account.

File types. Preferred formats for the text and tables of your manuscript are .doc, .rtf, .ppt, .xls. LaTeX files may be submitted provided that an .eps or .pdf file is provided in addition to the source files. Figures may be provided in .tiff or .eps format.

INITIAL SUBMISSION

NON-LATEX USERS: Editable source files must be uploaded at this stage. Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate figure files.

LATEX USERS: For reviewing purposes you should upload a single .pdf that you have generated from your source files. You must use the File Designation "Main Document" from the dropdown box.

REVISION SUBMISSION

NON-LATEX USERS: Editable source files must be uploaded at this stage. Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate figure files.

LATEX USERS: When submitting your revision you must still upload a single .pdf that you have generated from your now revised source files. You must use the File Designation "Main Document" from the dropdown box. In addition you must upload your TeX source files. For all your source files you must use the File Designation "Supplemental Material not for review". Previous versions of uploaded documents must be deleted. If your manuscript is accepted for publication we will use the files you upload to typeset your article within a totally digital workflow.

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Copyright and Permissions

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions http://authorservices.wiley.com/bauthor/faqs_copyright.asp

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution License OAA

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services http://authorservices.wiley.com/bauthor/faqs_copyright.asp and visit http://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.html.

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit: http://www.wiley.com/go/funderstatement.

Authors must sign, scan and upload to the online system:

• a Copyright Transfer Agreement with original signature(s) - without this we are unable to accept the submission, and
• permission grants - if the manuscript contains extracts, including illustrations, from other copyright works (including material from on-line or intranet sources) it is the author's responsibility to obtain written permission from the owners of the publishing rights to reproduce such extracts using the Wiley Permission Request Form

The Copyright Transfer Form and the Permissions Form should be uploaded as “Supplementary files not for review” with the online submission of your article.

If you do not have access to a scanner, further instructions will be given to you after acceptance of the manuscript.

To enable the publisher to disseminate the author's work to the fullest extent, the author must sign a Copyright Transfer Agreement, transferring copyright in the article from the author to the publisher, and submit the original signed agreement with the article presented for publication. Submission of a manuscript will be held to imply that it contains original unpublished work and is not being submitted for publication elsewhere at the same time. Submitted material will not be returned to the author, unless specifically requested

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Pre-Submission English Editing

Papers must be in English. Oxford English Dictionary or American spelling is acceptable, provided usage is consistent within the manuscript.

Manuscripts that are written in English that is ambiguous or incomprehensible, in the opinion of the Editor, will be returned to the authors with a request to resubmit once the language issues have been improved. This policy does not imply that all papers must be written in "perfect" English, whatever that may mean. Rather, the criterion will require that the intended meaning of the authors must be clearly understandable, i.e., not obscured by language problems, by referees who have agreed to review the paper.

Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at http://www.blackwellpublishing.com/bauthor/english_language.asp Japanese authors can also find a list of local English improvement services at http://www.wiley.co.jp/journals/editcontribute.html All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.

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Presentation of papers

Manuscript style. Use a standard font of the 12-point type: Times, Helvetica, or Courier is preferred. It is not necessary to double-line space your manuscript.

Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate figure files.

• During the submission process you must enter 1) the full title 2) the short title of up to 70 characters 3) names and affiliations of all authors and 4) the full address, including email, telephone and fax of the author who is to check the proofs.
• Include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s).
• Enter an abstract of no more than 250 words for all articles. Please see the guidance below on acceptable abstract writing for JLCR.
• Keywords. Authors should prepare no more than 10 keywords for their manuscript.

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Writing Abstracts

An abstract is a concise summary of the whole paper, not just the conclusions. The abstract should be no more than 250 words and convey the following:

1. An introduction to the work. This should be accessible by scientists in any field and express the necessity of the experiments executed

2. Some scientific detail regarding the background to the problem

3. A summary of the main result

4. The implications of the result

5. A broader perspective of the results, once again understandable across scientific disciplines

It is crucial that the abstract convey the importance of the work and be understandable without reference to the rest of the manuscript to a multidisciplinary audience. Abstracts should not contain any citation to other published works.

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Nomenclature, Abbreviations and Symbols

Nomenclature, abbreviations and symbols should follow the latest rules of the International Union of Pure and Applied Chemistry (IUPAC). In IUPAC nomenclature, isotopic substitution is indicated by a prefix consisting of (1) any necessary locant numeral or numerals; (2) the atomic symbol with the mass number as a superscript to the left of the symbol; and (3) a subscript (other than the unity) indicating the number of such atoms. Trivial names should be avoided unless the compound is to be mentioned often in the text, in which case a systematic name should also be given the first time the trivial name is used.

Journal of Labelled Compounds and Radiopharmaceuticals also touches on biology and medicine, and therefore a wide range of nomenclature rules apply./p>

For biological and biochemical nomenclature authors should conform to the (identical) guidelines published in J Biol Chem 260:16-42 (1985) and Eur J Biochem 138:9-37 (1984).

For biomedical nomenclature authors should conform to rules given in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals prepared by the International Steering Committee of Medical Editors. Reprints of this document are available from the Editor, Annals of Internal Medicine.

For questions of style, usage and punctuation, refer to The Chicago Manual of Style, which will be the final authority.

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Reference Style

References should be cited by superior numbers in square brackets and listed at the end of the paper in the order in which they appear in the text. Authors should cite available published work. If necessary, cite unpublished or personal work in the text but do not include them in the references list. Journal titles should be italicized and abbreviated in accordance with the “Chemical Abstracts Service Source Index” (CASSI; no commas appear in the journal names).

Examples for Journals

[1] R. K. Harris, A. Nordon, K. D. M. Harris, Rapid. Commun. Mass Spec. 2007 ; 21 , 15.

Examples for Books

[2] K. Schmidt-Rohr, H.W. Spiess, Multidimensional Solid-State NMR and Polymers, Academic Press, London, 1994 .

[3] V. Sklenar, in NMR Applications in Biopolymers , (Eds: J.W. Finley, S. J. Schmidt, A. S. Serianni), Plenum, New York, 1990 , pp. 63-70.

Examples for Websites

[4] The Oncology Website. http://www.mit.co/oncology/ [24 April 1999].

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Illustrations and ChemDraw Rules

Copy and paste all illustrations and chemical structures into the text file. In addition upload chemical structures as separate ChemDraw files [or similar chemical drawing packages] and all other figures as separate files in either .tiff or .eps format, with the figure number and the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be in a size related to the size given for chemical structures, and consistent within each figure and set of figures. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All illustrations must be supplied at the correct resolution:

• Black and white and colour photos - 300 dpi
• Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
• Combinations of photos and drawings (black and white and colour) - 500 dpi

Tables should be part of the the main document and should be placed after the references. If the table is created in excel the file should be uploaded separately.

Chemical structures have to be prepared in ChemDraw either 80mm (onecolumn)or175mm (twocolumn) widths. However, the one-column format should be used whenever possible as this allows greater flexibility in the layout of the manuscript.Use this ChemDraw Download template or use the following settings:

Drawing settings		Text settings
chain angle	120°	font	Arial
bond spacing	18% of length	size	12 pt
fixed length	17 pt
bond width	2 pt	Preferences
line width	0.75 pt	units	points
margin width	2 pt	tolerances	5 pixels
hash spacing	2.6 pt
Bold width	2.6 pt

Authors using different structural drawing programs should choose settings consistent with those above. Compound numbers should be bold, but not atom labels or captions.

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Graphical Table of Contents

JLCR’s table of contents will be presented in graphical form with a brief abstract.

The table of contents entry must include the article title, the authors' names (with the corresponding author indicated by an asterisk), no more than 80 words or 3 sentences of text summarising the key findings presented in the paper and a figure that best represents the scope of the paper. (see the section on abstract writing for more guidance).

Table of contents entries should be submitted to Manuscript Central in one of the generic file formats and uploaded as ‘Supplementary material for review’ during the initial manuscript submission process.

The image supplied should fit within the dimensions of 50mm x 60mm, and be fully legible at this size.

Examples for arranging the text and figures as well as paper title and authors' names are shown below.

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Colour policy

When considered necessary by the Editors, two colour pages per article will be printed free of charge. The cost of additional colour illustrations printed in the journal will be charged to the author. If colour illustrations are supplied electronically in either TIFF or EPS format, they may be used in the PDF of the article at no cost to the author, even if this illustration was printed in black and white in the journal. The PDF will appear on the Wiley Online Library site.

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Citing EarlyView Articles

To include the DOI in a citation to an article, simply append it to the reference as in the following example:

R. K. Harris, A. Nordon, K. D. M. Harris, Rapid. Commun. Mass Spec. 2007, DOI: 10.1002/rcm.21464.

To link to an article from the author’s homepage, take the DOI (digital object identifier) and append it to "http://dx.doi.org/" as per following example:

DOI 10.1002/JLCR.20941, becomes http://dx.doi.org/10.1002/JLCR.20941.

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Supporting Information

Data that are (i) not amenable to presentation in a traditional print format, (ii) of interest primarily to specialists and do not require Journal page space, or (iii) particularly useful to the community in electronic (downloadable) form can be published online as supplementary material hosted within Wiley Online Library.

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Ethical Treatment of Humans and Animals

All human and animal studies must be approved by an appropriate ethics committee or review board (depending on local arrangements), and a statement to this effect should be included in the methods section, or the reasons why it was not necessary if this is the case. All clinical investigations must have been conducted according to the principles expressed in the Declaration of Helsinki ( http://www.wma.net).

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Article formats published in JLCR

Journal of Labelled Compounds and Radiopharmaceuticals publishes Reviews, Research Articles, Short Notes, Technical Notes, News, Diary and Conference Announcements. Submitted manuscripts should not have been previously published and should not be submitted for publication elsewhere while they are under consideration by Wiley. Receipt of papers will be acknowledged. Submitted material will not be returned to the author, unless specifically requested.

Research Articles must either be of current general interest or of great significance to a more specialized readership. They are peer-reviewed and report details of studies that have not been published previously, except in the form of a preliminary communication (reprint requested). Manuscripts should be between 15 and 20 pages in length (double spaced), and be divided into sections in the following order: Introduction, Experimental, Results and Discussion, Conclusions, Acknowledgements, References.

Short Notes follow the style of Research Articles but should not exceed 4 printed pages.

Technical Notes should not exceed on printed page.

Reviews. The submission of Reviews is encouraged. The Journal of Labelled Compounds and Radiopharmaceuticals accepts different styles of Reviews, such as Comprehensive Reviews, Critical or Personal Reviews, Educational Reviews and Technical Reviews. Prior consultation with the Reviews Editors is advised!

News and Diary. News and Diary on forthcoming meetings, publications, legislation and new products are invited and should be sent to the Editor-in-Chief.

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Further Information

For accepted manuscripts the publisher will supply proofs to the submitting author prior to publication. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue. Free access to the final PDF offprint or your article will be available via Author Services only. Please therefore sign up for Author Services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers. There is no page charge to authors.

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