Journal of Labelled Compounds and Radiopharmaceuticals

Cover image for Vol. 59 Issue 9

Editors-in-Chief: R F Dannals and K M W Lawrie

Impact Factor: 1.532

ISI Journal Citation Reports © Ranking: 2015: 42/59 (Chemistry Medicinal); 47/75 (Chemistry Analytical); 62/77 (BIOCHEMICAL RESEARCH METHODS)

Online ISSN: 1099-1344

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Young Scientists Award

Congratulations to the 2015 Young Scientists JLCR Awardees

JLCR_award_winners

From left to right
Renyuan Yu (Princeton University)
Iron catalysed hydrogen isotope exchange in drug molecules

Dr Marc Reid (University of Edinburgh)
Design and application of Iridium catalysts for C-H activation towards hydrogen Isotope exchange processes

Ken Lawrie
Editor-in-Chief

Miss Philippa Owens (University of Strathclyde)
Iridium catalysed hydrogen isotope exchange for the regioselective deuteration of N-heterocycles

Thomas Andersen (Aarhus University)
Efficient 11C-carbonylation of isolated aryl palladium complexes for PET:application to challenging radiopharmaceutical synthesis

Recently Published Articles

  1. Adding value through accelerator mass spectrometry-enabled first in human studies

    Mark A. Seymour

    Version of Record online: 22 JUL 2016 | DOI: 10.1002/jlcr.3420

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    Accelerator mass spectrometry can be used to enhance the design of first in human clinical studies and generate significant additional data, including intravenous pharmacokinetics, absolute bioavailability, mass balance, excretion, metabolic fate and tissue disposition. The approach requires relatively little additional expense and can save significant time compared with conventional approaches.

  2. 177Lu-5-Fluorouracil a potential theranostic radiopharmaceutical: radiosynthesis, quality control, biodistribution, and scintigraphy

    Rashid Rasheed, Saleha Tariq, Syed Ali Raza Naqvi, Syed Jawad Hussain Gillani, Faheem Askari Rizvi, Muhammad Sajid and Shahid Rasheed

    Version of Record online: 22 JUL 2016 | DOI: 10.1002/jlcr.3423

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    5-Flourouracil (5-FU) is widely accepted as an anti-cancer chemotherapeutic drug of broad spectrum fame. The labeling of 5-FU was carried out using β-rays emitter radionuclide (lutetium-177) to develop therapeutic radiopharmaceuticals.

  3. Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia

    Evelyn Laurens, Shinn Dee Yeoh, Angela Rigopoulos, Graeme J. O'Keefe, Henri J. Tochon-Danguy, Lee Wenn Chong, Jonathan M. White, Andrew M. Scott and Uwe Ackermann

    Version of Record online: 19 JUL 2016 | DOI: 10.1002/jlcr.3426

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    A new nitrophenyl sulfoxide for imaging hypoxia was synthesized via halogen exchange in non-decay corrected yields of radioactivity of 1.18 ± 0.24%. The radiotracer was investigated in our well-established SK-RC-52 model of tumor hypoxia and its pharmacokinetics compared with [18F]FMISO. The fast clearance of [18F]1 from normoxic tissue allows for imaging at earlier timepoints than [18F]FMISO. This compound is an interesting lead structure for further development of hypoxia tracers.

  4. Synthesis and quality control of [18F]T807 for tau PET imaging

    Daniel P. Holt, Hayden T. Ravert and Robert F. Dannals

    Version of Record online: 17 JUL 2016 | DOI: 10.1002/jlcr.3425

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    The detailed synthesis and quality control of [18F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/μmole (120 Ci/μmole) and an average radiochemical yield of 32%. Compliance with all standard USP Chapter <823> acceptance tests was observed.

  5. Evaluation of C18 monolithic columns for radiochemical purity measurement

    David J. Schenk, Christopher J. Welch and Vincent Antonucci

    Version of Record online: 13 JUL 2016 | DOI: 10.1002/jlcr.3422

    Thumbnail image of graphical abstract

    The performance of a C18 monolithic column was evaluated by comparing its radiochemical results with those from a traditional 25-cm C18 column. Most results were similar for the 54 compounds assayed, but a few cases with large differences (>1%) were found. A confidence of ~85% was calculated for the 15-min monolithic method's ability to reproduce the conventional column result.

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