Detecting breast microcalcifications with high-field MRI
Hendrik de Leeuw, Bertine L. Stehouwer, Chris J. G. Bakker, Dennis W. J. Klomp, Paul J. van Diest, Peter R. Luijten, Peter R. Seevinck, Maurice A. A. J. van den Bosch, Max A. Viergever and Wouter B. Veldhuis
Article first published online: 17 FEB 2014 | DOI: 10.1002/nbm.3089
Ductal carcinoma in situ is considered to be a potential precursor of invasive ductal carcinoma which, in 62–89% of cases, presents with microcalcifications in mammography (a). MRI (b) has shown improved breast lesion detection compared with mammography, but suffers from limited specificity. The specificity of MRI might be improved by the imaging of microcalcifications. We show that the phase derivative (c) of a gradient-echo MRI acquisition (b) allows the three-dimensional distribution of microcalcifications to be imaged in human whole breast specimens (d).