© John Wiley & Sons Ltd
Editor-in-Chief: Satyajit D. Sarker
Impact Factor: 2.497
ISI Journal Citation Reports © Ranking: 2015: 25/75 (Chemistry Analytical); 37/77 (BIOCHEMICAL RESEARCH METHODS); 49/209 (Plant Sciences)
Online ISSN: 1099-1565
Many Congratulations to Award Winners
Congratulations to Andy J. Pérez, Institute of Soil Science and Plant Cultivation, State Research Institute, Poland and Jan Šimura, Palacký University of Olomouc, Czech Republic on winning the PCA best oral presentation awards at the 2016 Trends in Natural Products Research conference, and to Yaroslav Faletrov, Belarusian State University, Belarus on winning the PCA best oral presentation award at the 23rd Conference on Isoprenoids in Minsk.
Recently Published Articles
- Chemical Profiling Combined with “Omics” Technologies (CP-Omics): a Strategy to Understand the Compatibility Mechanisms and Simplify Herb Formulas in Traditional Chinese Medicines
Tengfei Xu, Zifeng Pi, Shu Liu, Fengrui Song and Zhiqiang Liu
Version of Record online: 7 APR 2017 | DOI: 10.1002/pca.2685
- •A novel herb formula discovery strategy in traditional Chinese medicine (TCM) based on chemical profiling combined with “omics” technologies (CP-omics) was developed.
- •CP-omics could multi-analyse the contents of great many compounds simultaneously.
- •CP-omics method contributes to understand the inter mechanisms of formula.
- •CP-omics possesses advantages in simplify complex formulas.
- •Pharmacological results verified the rationality of the new herb combination.
- An Optimised Method for Routine Separation and Quantification of Major Alkaloids in Cortex Cinchona by HPLC Coupled with UV and Fluorescence Detection
Else Holmfred, Claus Cornett, Carla Maldonado, Nina Rønsted and Steen Honoré Hansen
Version of Record online: 31 MAR 2017 | DOI: 10.1002/pca.2684
Authentication of herbal products to ensure efficacy and safety require efficient separation and quantification of constituents. Numerous minor alkaloids occur in Cinchona bark used for the treatment of malaria and production of quinine. An optimised HPLC-UV method facilitates efficient separation and quantification of the four major Cinchona alkaloids in 26 min with a limit of quantification of 5 μg/g from 50 mg bark sample.
- Ultra-Performance Liquid Chromatography Hyphenated with Quadrupole-Orbitrap Mass Spectrometry for Simultaneous Determination of Necine-Core-Structure Pyrrolizidine Alkaloids in Crotalaria sessiliflora L. without all Corresponding Standards
Wei Zhang, Wenbei Huai, Yi Zhang, Jincan Shen, Xunyou Tang, Xiujuan Xie, Ke Wang and Huajun Fan
Version of Record online: 23 MAR 2017 | DOI: 10.1002/pca.2683
A novel UPLC-Q-Orbitrap/MS method of simultaneous determination of five pyrrolizidine alkaloids (PAs) in Crotalaria sessiliflora L. was developed by UPLC-Q-Orbitrap/MS for quality control and pharmaceutical uses. Based on the characteristic fragmentation pattern, five coexisting PAs in the herb were identified by full MS-dd-MS2 mode. Quantification of PAs successfully completed by parallel reaction monitoring mode using m/z 138, m/z 120 and m/z 94 from identical necine-core structure as quantitative ions with single monocrotaline standard for accurate calibration.
- Efficient Discovery of Quality Control Markers for Gastrodia elata Tuber by Fingerprint-Efficacy Relationship Modelling
Mingfang Li, Yuan Du, Long Wang, Lilong Jiang, Xiaodong Ma, Ping Zhou, Ping Li and Huijun Li
Version of Record online: 20 MAR 2017 | DOI: 10.1002/pca.2682
The fingerprint-efficacy relationship modelling between chemical fingerprint and bioactivity was developed for discovering the efficacy-related quality control markers (QCMs), using Gastrodia elata tuber (GET) as a case study. The chemical combination of 5-hydroxymethyl-2-furaldehyde, parishin B and parishin C was discovered by orthogonal projection to latent structure-discriminant analysis model and confirmed as QCMs of GET by the orthogonal projection to latent structure-discriminant analysis method. This fingerprint-efficacy relationship modelling strategy might be generally applicable for the quality control of herbal medicines.
- Rapid Analysis of Corni fructus Using Paper Spray-Mass Spectrometry
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen and Liping Wang
Version of Record online: 26 FEB 2017 | DOI: 10.1002/pca.2681
MS profile of Corni Fructus (aka Shanzhuyu in Chinese) was constructed by paper spray-MS (PS-MS). Using PS-MS chemical profile, Corni fructus and Crataegi fructus samples are clustered into two categories clearly by PCA analysis. Rapid semi-quantitative analysis of loganin and morroniside in the extracts of Corni fructus was completed by PS-MS.