Phytotherapy Research

Cover image for Vol. 30 Issue 9

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Elizabeth M. Williamson, Angelo A Izzo, Sung Hoon-Kim and Rajan Radhakrishnan

Impact Factor: 2.694

ISI Journal Citation Reports © Ranking: 2015: 28/59 (Chemistry Medicinal); 94/253 (Pharmacology & Pharmacy)

Online ISSN: 1099-1573


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  1. Research Articles

    1. Antiinflammatory Effects of Functionally Active Compounds Isolated from Aged Black Garlic

      Dong-gyu Kim, Min Jung Kang, Seong Su Hong, Yun-Hyeok Choi and Jung Hye Shin

      Version of Record online: 30 SEP 2016 | DOI: 10.1002/ptr.5726

    2. Inhibitory Effects of Multiple-Dose Treatment with Baicalein on the Pharmacokinetics of Ciprofloxacin in Rats

      Youn-Hwan Hwang, Hye Jin Yang, Dong-Gun Kim and Jin Yeul Ma

      Version of Record online: 26 SEP 2016 | DOI: 10.1002/ptr.5728

  2. Reviews

    1. A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

      Bhesh Raj Sharma, Lekh Nath S. Gautam, Deepak Adhikari and Rajendra Karki

      Version of Record online: 26 SEP 2016 | DOI: 10.1002/ptr.5732

  3. Research Articles

    1. THC (Δ9-Tetrahydrocannabinol) Exerts Neuroprotective Effect in Glutamate-affected Murine Primary Mesencephalic Cultures Through Restoring Mitochondrial Membrane Potential and Anti-apoptosis Involving CB1 Receptor-dependent Mechanism

      Chi Huu Nguyen, Christopher Krewenka, Khaled Radad, Barbara Kranner, Alexandra Huber, Johanna Catharina Duvigneau, Ingrid Miller and Rudolf Moldzio

      Version of Record online: 22 SEP 2016 | DOI: 10.1002/ptr.5712

    2. Antimycobacterial Activity and Low Cytotoxicity of Leaf Extracts of Some African Anacardiaceae Tree Species

      Prudence N. Kabongo-Kayoka, Jacobus N. Eloff, Chikwelu L. Obi and Lyndy J. McGaw

      Version of Record online: 13 SEP 2016 | DOI: 10.1002/ptr.5706

    3. Characterization of Phloroglucinol-enriched Fractions of Brazilian Hypericum Species and Evaluation of Their Effect on Human Keratinocytes Proliferation

      Henrique Bridi, Aline Beckenkamp, Gari Vidal Ccana-Ccapatinta, Sérgio Augusto de Loreto Bordignon, Andréia Buffon and Gilsane Lino von Poser

      Version of Record online: 13 SEP 2016 | DOI: 10.1002/ptr.5727

    4. Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression

      Hyeong Sim Choi, Sung-Gook Cho, Min Kyoung Kim, Min Soo Kim, Seung Hee Moon, Il Hwan Kim and Seong-Gyu Ko

      Version of Record online: 8 SEP 2016 | DOI: 10.1002/ptr.5708

    5. Perioperative Bromelain Therapy after Wisdom Teeth Extraction – A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study

      Kai-Hendrik Bormann, Kristina Weber, Heike Kloppenburg, Armin Koch, Peter Meiser and Nils-Claudius Gellrich

      Version of Record online: 6 SEP 2016 | DOI: 10.1002/ptr.5707

    6. Germacrone Inhibits Estrogen Receptor α-Mediated Transcription in MCF-7 Breast Cancer Cells

      Mi-Sun Lim, Se-Young Choung and Kwang Won Jeong

      Version of Record online: 30 AUG 2016 | DOI: 10.1002/ptr.5711

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      Cinnamaldehyde, Carvacrol and Organic Acids Affect Gene Expression of Selected Oxidative Stress and Inflammation Markers in IPEC-J2 Cells Exposed to Salmonella typhimurium

      Sara A. Burt, Simone J.M. Adolfse, Dina S.A. Ahad, Monique H.G. Tersteeg-Zijderveld, Betty G.M. Jongerius-Gortemaker, Jan A. Post, Holger Brüggemann and Regiane R. Santos

      Version of Record online: 25 AUG 2016 | DOI: 10.1002/ptr.5705

    8. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

      Sepideh Elyasi, Sare Hosseini, Mohammad Reza Niazi Moghadam, Seyed Amir Aledavood and Gholamreza Karimi

      Version of Record online: 23 AUG 2016 | DOI: 10.1002/ptr.5704

    9. Inulin-Type Oligosaccharides Extracted from Yacon Produce Antidepressant-Like Effects in Behavioral Models of Depression

      Lei An, Ji-Chu Yang, Hang Yin, Rui Xue, Qiong Wang, Yu Chen Sun, You-Zhi Zhang and Ming Yang

      Version of Record online: 19 AUG 2016 | DOI: 10.1002/ptr.5698

  4. Reviews

    1. Overview of Oroxylin A: A Promising Flavonoid Compound

      Lu Lu, Qinglong Guo and Li Zhao

      Version of Record online: 19 AUG 2016 | DOI: 10.1002/ptr.5694

  5. Research Articles

    1. Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-α and IL-β Through PI3K/Akt/NF-kb Signaling Pathways

      Min Ho Han, Won Sup Lee, Arulkumar Nagappan, Su Hyun Hong, Ji Hyun Jung, Cheol Park, Hye Jung Kim, Gi-Young Kim, GonSup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong and Yung Hyun Choi

      Version of Record online: 18 AUG 2016 | DOI: 10.1002/ptr.5688

    2. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B

      Xin Liu, Da-Wei Chen, Xue Wu, Zhenying Zhao, Zhi-Wei Fu, Chun-Ting Huang, Li-Xin Ye, Zuo Du, Yang Yu, Zhong-Ze Fang and Hong-Zhi Sun

      Version of Record online: 18 AUG 2016 | DOI: 10.1002/ptr.5697

    3. Plumbagin Enhances Tamoxifen Sensitivity and Inhibits Tumor Invasion in Endocrine Resistant Breast Cancer through EMT Regulation

      Nithidol Sakunrangsit, Nuttiya Kalpongnukul, Trairak Pisitkun and Wannarasmi Ketchart

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5702

  6. Reviews

    1. Progress in the Development and Applicability of Potential Medicinal Plant Extract-Conjugated Polymeric Constructs for Wound Healing and Tissue Regeneration

      Urmimala Das, Sudhanshu Shekhar Behera, Sandeep Singh, Syed Ibrahim Rizvi and Abhishek Kumar Singh

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5700

  7. Research Articles

    1. Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells

      M. Prata-Sena, A.A. Ramos, S. Buttachon, B. Castro-Carvalho, P. Marques, T. Dethoup, A. Kijjoa and E. Rocha

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5696

  8. Reviews

    1. Berberis Vulgaris and Berberine: An Update Review

      Mohsen Imenshahidi and Hossein Hosseinzadeh

      Version of Record online: 16 AUG 2016 | DOI: 10.1002/ptr.5693

  9. Research Articles

    1. Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

      Fatemeh Forouzanfar, Hossein Hosseinzadeh, Alireza Ebrahimzadeh Bideskan and Hamid R. Sadeghnia

      Version of Record online: 12 AUG 2016 | DOI: 10.1002/ptr.5701

    2. Magnolol Enhances Hippocampal Neurogenesis and Exerts Antidepressant-Like Effects in Olfactory Bulbectomized Mice

      Nobuaki Matsui, Haruka Akae, Nana Hirashima, Yuki Kido, Satoshi Tanabe, Mayumi Koseki, Yoshiyasu Fukuyama and Masaaki Akagi

      Version of Record online: 11 AUG 2016 | DOI: 10.1002/ptr.5695

  10. Short Communications

    1. Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats

      Ying Deng, Yu-fei Mo, Xin-meng Chen, Lv-zhao Zhang, Chao-feng Liao, Yu Song and Chenshu Xu

      Version of Record online: 4 AUG 2016 | DOI: 10.1002/ptr.5691

  11. Research Articles

    1. Obovatol Induces Apoptosis in Non-small Cell Lung Cancer Cells via C/EBP Homologous Protein Activation

      Heejeong Kim, Eun Ah Shin, Chang Geun Kim, Dae Young Lee, Bonglee Kim, Nam-In Baek and Sung-Hoon Kim

      Version of Record online: 4 AUG 2016 | DOI: 10.1002/ptr.5690

    2. In Vitro Assessment of Plants Growing in Cuba Belonging to Solanaceae Family Against Leishmania amazonensis

      Lianet Monzote, Jenny Jiménez, Osmany Cuesta-Rubio, Ingrid Márquez, Yamile Gutiérrez, Cláudia Quintino da Rocha, Mary Marchi, William N. Setzer and Wagner Vilegas

      Version of Record online: 2 AUG 2016 | DOI: 10.1002/ptr.5681

    3. Synergistic Effect of SH003 and Doxorubicin in Triple-negative Breast Cancer

      Sang-Mi Woo, Ah Jeong Kim, Youn Kyung Choi, Young Cheol Shin, Sung-Gook Cho and Seong-Gyu Ko

      Version of Record online: 1 AUG 2016 | DOI: 10.1002/ptr.5687

    4. Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling

      Boram Kim, Narae Jung, Sanghun Lee, Jae Kyung Sohng and Hye Jin Jung

      Version of Record online: 29 JUL 2016 | DOI: 10.1002/ptr.5689

    5. Silibinin Inhibits Neutrophilic Inflammation and Mucus Secretion Induced by Cigarette Smoke via Suppression of ERK-SP1 Pathway

      Ji-Won Park, Na-Rae Shin, In-Sik Shin, Ok-Kyoung Kwon, Joong-Sun Kim, Sei-Ryang Oh, Jae-hong Kim and Kyung-Seop Ahn

      Version of Record online: 29 JUL 2016 | DOI: 10.1002/ptr.5686

    6. Effects of Ginkgo Biloba Extract EGb-761 on Neuropathic Pain in Mice: Involvement of Opioid System

      Chao Zhu, Wei Li, Fan Xu, Mo Li, Liu Yang, Xue-Yu Hu, Zheng-Xu Ye, Zhe Wang and Zhuo-Jing Luo

      Version of Record online: 25 JUL 2016 | DOI: 10.1002/ptr.5685

    7. Bacopa monnieri-Induced Protective Autophagy Inhibits Benzo[a]pyrene-Mediated Apoptosis

      Durgesh Nandini Das, Prajna Paramita Naik, Aditi Nayak, Prashanta Kumar Panda, Subhadip Mukhopadhyay, Niharika Sinha and Sujit K Bhutia

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/ptr.5682

    8. The Water Fraction of Calendula officinalis Hydroethanol Extract Stimulates In Vitro and In Vivo Proliferation of Dermal Fibroblasts in Wound Healing

      Manikarna Dinda, Swagata Mazumdar, Saurabh Das, Durba Ganguly, Uma B Dasgupta, Ananya Dutta, Kuladip Jana and Parimal Karmakar

      Version of Record online: 18 JUL 2016 | DOI: 10.1002/ptr.5678

  12. Reviews

    1. Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Cognitive Outcomes

      Lin Dong, Brian H May, Mei Feng, Anna J Hyde, Hsiewe Ying Tan, Xinfeng Guo, Anthony Lin Zhang, Chuanjian Lu and Charlie Changli Xue

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/ptr.5679

    2. Pharmacological Effects of Capparis spinosa L.

      Seyed Fazel Nabavi, Filippo Maggi, Maria Daglia, Solomon Habtemariam, Luca Rastrelli and Seyed Mohammad Nabavi

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5684

  13. Research Articles

    1. Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes

      Min-Jung Seo, Young-Jin Seo, Cheol-Ho Pan, Ok-Hwan Lee, Kui-Jin Kim and Boo-Yong Lee

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5683

      Thumbnail image of graphical abstract

      We provide evidence that fucoxanthin suppresses protein levels of the adipogenic transcription factors and lipogenesis-associated enzymes in 3T3-L1. The reactive oxygen species (ROS) producing enzyme NOX4 and the nicotinamide adenine dinucleotide phosphate-generating enzyme glucose-6-phosphate dehydrogenase is also decreased in 3T3-L1 treated with fucoxanthin. Moreover, fucoxanthin inhibits the accumulation of intracellular lipid and the production of ROS in high-fat diet-induced obese zebrafish model. Therefore, our data suggest that fucoxanthin inhibits lipid accumulation and ROS production by controlling adipogenic factors and ROS-regulating enzymes in vitro and in vivo.

    2. You have free access to this content
      A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study

      S. Shamshad Begum, H. K. Jayalakshmi, H. G. Vidyavathi, G. Gopakumar, Issac Abin, Maliakel Balu, K. Geetha, S. V. Suresha, M. Vasundhara and I. M. Krishnakumar

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5680

  14. Reviews

    1. Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

      Roghayeh Javan, Mahdi Yousefi, Seyed-Mohammad Nazari, Parastoo Amiri, Alireza Mosavi-Jarrahi, Parvaneh Modiramani and Hamideh Naghedi-Baghdar

      Version of Record online: 10 JUL 2016 | DOI: 10.1002/ptr.5675

  15. Research Articles

    1. Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/β-catenin Signaling Pathway

      Xun Cheng, Biaofang Wei, Lijuan Sun, Xiaofang Hu, Jichao Liang and Yong Chen

      Version of Record online: 10 JUL 2016 | DOI: 10.1002/ptr.5674

    2. Drug Resistance Reversal Potential of Isoliquiritigenin and Liquiritigenin Isolated from Glycyrrhiza glabra Against Methicillin-Resistant Staphylococcus aureus (MRSA)

      Rashmi Gaur, Vivek Kumar Gupta, Pooja Singh, Anirban Pal, Mahendra Padurang Darokar and Rajendra Singh Bhakuni

      Version of Record online: 8 JUL 2016 | DOI: 10.1002/ptr.5677

  16. Research articles

    1. Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB

      Young Sook Yun, Miki Tajima, Shigeru Takahashi, Yuji Takahashi, Mariko Umemura, Haruo Nakano, Hyun Sun Park and Hideshi Inoue

      Version of Record online: 8 JUL 2016 | DOI: 10.1002/ptr.5676

      Thumbnail image of graphical abstract

      Lycoricidine and lycoricidinol, from methanol extract of Lycoris sanguineas uppressed the expression of a reporter gene under the control of cAMP response element and also prevented increases in the endogenous levels of phosphorylated cAMP response element-binding protein and phosphoenolpyruvate carboxykinase mRNA expression. These results suggest that lycoricidine and lycoricidinol suppress cytosolic phosphoenolpyruvate carboxykinase expression by inhibiting the phosphorylation of cAMP response element-binding protein and may thus have the potential to prevent excessive gluconeogenesis in type 2 diabetes.

  17. Reviews

    1. The Mechanisms of Pharmacological Activities of Ophiocordyceps sinensis Fungi

      Jin Xu, Ying Huang, Xiang-Xiang Chen, Shuai-Chao Zheng, Peng Chen and Ming-He Mo

      Version of Record online: 3 JUL 2016 | DOI: 10.1002/ptr.5673

  18. Research Articles

    1. The Suppressive Effects of the Petroleum Ether Fraction from Atractylodes lancea (Thunb.) DC. On a Collagen-Induced Arthritis Model

      Renping Liu, Enwei Tao, Shuwen Yu, Bo Liu, Lingman Dai, Liangyu Yu, Yifeng Xiong, Ruijun Fu, Lang Lei and Xiaoping Lai

      Version of Record online: 3 JUL 2016 | DOI: 10.1002/ptr.5671

    2. The Impact of Cocoa Flavanols on Cardiovascular Health

      Julia Vlachojannis, Paul Erne, Benno Zimmermann and Sigrun Chrubasik-Hausmann

      Version of Record online: 1 JUL 2016 | DOI: 10.1002/ptr.5665

  19. Short Communications

    1. Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells

      Kashif M. Khan, Lutfun Nahar, Afaf Al-Groshi, Alexandra G. Zavoianu, Andrew Evans, Nicola M. Dempster, Jean D. Wansi, Fyaz M. D. Ismail, Abdul Mannan and Satyajit D. Sarker

      Version of Record online: 1 JUL 2016 | DOI: 10.1002/ptr.5672

  20. Research Articles

    1. Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis

      Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu and Ganzhen Deng

      Version of Record online: 23 JUN 2016 | DOI: 10.1002/ptr.5666

  21. Reviews

  22. Research Articles

    1. Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts

      Adnan Amin, Emmy Tuenter, Vassiliki Exarchou, Atul Upadhyay, Paul Cos, Louis Maes, Sandra Apers and Luc Pieters

      Version of Record online: 10 JUN 2016 | DOI: 10.1002/ptr.5663

    2. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial

      Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi and Sin Gon Kim

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5664

  23. Reviews

    1. An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?

      Javier Rodríguez Villanueva and Jorge Martín Esteban

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/ptr.5661

  24. Research Articles

    1. Nimbolide Inhibits Nuclear Factor-КB Pathway in Intestinal Epithelial Cells and Macrophages and Alleviates Experimental Colitis in Mice

      Ji Yeon Seo, Changhyun Lee, Sung Wook Hwang, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/ptr.5657

    2. Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients—A Pilot Study

      Andrea Čabarkapa, Lada Živković, Sunčica Borozan, Mirjana Zlatković-Švenda, Dragana Dekanski, Ivan Jančić, Marija Radak-Perović, Vladan Bajić and Biljana Spremo-Potparević

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/ptr.5662


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