Phytotherapy Research

© John Wiley & Sons, Ltd.

Cover image for Vol. 27 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Elizabeth M. Williamson, Angelo A Izzo, Sung Hoon-Kim and Rajan Radhakrishnan

Impact Factor: 2.086

ISI Journal Citation Reports © Ranking: 2011: 32/59 (Chemistry Medicinal); 135/261 (Pharmacology & Pharmacy)

Online ISSN: 1099-1573

  1. Letters to the Editor

    1. Pro and Contra Duration Restriction of Treatment with Willow Bark Extract

      C. Vlachojannis, F. Magora and Sigrun Chrubasik-Hausmann

      Article first published online: 23 MAY 2013 | DOI: 10.1002/ptr.5008

  2. Research Articles

    1. Brassinin Induces Apoptosis in PC-3 Human Prostate Cancer Cells through the Suppression of PI3K/Akt/mTOR/S6K1 Signaling Cascades

      Sung-Moo Kim, Jeong Ha Park, Ki Dong Kim, Dongwoo Nam, Bum Sang Shim, Sung-Hoon Kim, Kyoo Seok Ahn, Seung-Hoon Choi and Kwang Seok Ahn

      Article first published online: 20 MAY 2013 | DOI: 10.1002/ptr.5010

    2. Improved Lipid Profile in Hyperlipidemic Patients Taking Vaccinium arctostaphylos Fruit Hydroalcoholic Extract: A Randomized Double-Blind Placebo-Controlled Clinical Trial

      S. Kianbakht, B. Abasi and Fataneh Hashem Dabaghian

      Article first published online: 20 MAY 2013 | DOI: 10.1002/ptr.5011

    3. Evaluation of the Effect of Blackcurrant Products on Gut Microbiota and on Markers of Risk for Colon Cancer in Humans

      Abdul-Lateef Molan, Zhuojian Liu and Gabriel Plimmer

      Article first published online: 15 MAY 2013 | DOI: 10.1002/ptr.5009

    4. Hesperidin Prevents Androgen Deficiency-induced Bone Loss in Male Mice

      Hiroshige Chiba, Hyounju Kim, Akiyo Matsumoto, Satoko Akiyama, Yoshiko Ishimi, Kazuharu Suzuki and Mariko Uehara

      Article first published online: 15 MAY 2013 | DOI: 10.1002/ptr.5001

  3. Reviews

    1. Aldose Reductase Inhibitors of Plant Origin

      Ciddi Veeresham, Ajmeera Rama Rao and Kaleab Asres

      Article first published online: 15 MAY 2013 | DOI: 10.1002/ptr.5000

  4. Research Articles

    1. Comparison Between the Efficacy of Ginger and Sumatriptan in the Ablative Treatment of the Common Migraine

      Maghbooli Mehdi, Golipour Farhad, Moghimi Esfandabadi Alireza and Yousefi Mehran

      Article first published online: 9 MAY 2013 | DOI: 10.1002/ptr.4996

    2. Anti-inflammatory Activities of an Active Fraction Isolated from the root of Astragalus membranaceus in RAW 264.7 Macrophages

      Patrick Kwok-Kin Lai, Judy Yuet-Wa Chan, Shi-Biao Wu, Ling Cheng, Grace Ka-Wai Ho, Ching-Po Lau, Edward J. Kennelly, Ping-Chung Leung, Kwok-Pui Fung and Clara Bik-San Lau

      Article first published online: 3 MAY 2013 | DOI: 10.1002/ptr.5002

    3. Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells

      Song Hyo Sook, Hyo-Jung Lee, Ji-Hyun Kim, EunJung Sohn, Ji Hoon Jung, Bonglee Kim, Jin-Hyoung Kim, Soo-Jin Jeong and Sung-Hoon Kim

      Article first published online: 3 MAY 2013 | DOI: 10.1002/ptr.4999

    4. Possible Adverse Reactions to Herbal Products: A Study with Individuals Who Resort To Popular Medicine in the City of Diadema, SP, Brazil

      Julino A. R. Soares Neto, José Carlos F. Galduróz, Luis Carlos Marques, Edna Tomiko Kato, Thiago Macrini and Eliana Rodrigues

      Article first published online: 3 MAY 2013 | DOI: 10.1002/ptr.5004

  5. Clarification

    1. Clarification

      Article first published online: 3 MAY 2013 | DOI: 10.1002/ptr.5007

  6. Reviews

    1. Piper nigrum and Piperine: An Update

      Murlidhar Meghwal and T. K. Goswami

      Article first published online: 28 APR 2013 | DOI: 10.1002/ptr.4972

  7. Short Communications

    1. Effect of Resveratrol on Cultured Skin Fibroblasts from Patients with Oxidative Phosphorylation Defects

      Boel De Paepe, Katrien Vandemeulebroecke, Joél Smet, Arnaud Vanlander, Sara Seneca, Willy Lissens, Johan LK Van Hove, Ellen Deschepper, Paz Briones and Rudy Van Coster

      Article first published online: 26 APR 2013 | DOI: 10.1002/ptr.4988

  8. Research Articles

    1. Therapeutic Effect of Rhizoma Dioscoreae Nipponicae on Gouty Arthritis Based on the SDF-1/CXCR 4 and p38 MAPK Pathway: An In Vivo and In Vitro Study

      Fang Lu, Lei Liu, Dong-hua Yu, Xu-zhao Li, Qi Zhou and Shu-min Liu

      Article first published online: 26 APR 2013 | DOI: 10.1002/ptr.4997

    2. Comparison of Inhibition Capability of Scutellarein and Scutellarin Towards Important Liver UDP-Glucuronosyltransferase (UGT) Isoforms

      Guang-You Ma, Yun-Feng Cao, Cui-Min Hu, Zhong-Ze Fang, Xiao-Yu Sun, Mo Hong and Zhi-Tu Zhu

      Article first published online: 26 APR 2013 | DOI: 10.1002/ptr.4990

    3. The Beneficial Effect of Total Glucosides of Paeony on Psoriatic Arthritis Links to Circulating Tregs and Th1 Cell Function

      Yi Na Wang, Yu Zhang, Yan Wang, Ding Xian Zhu, Li Qin Xu, Hong Fang and Wei Wu

      Article first published online: 23 APR 2013 | DOI: 10.1002/ptr.5005

    4. Hypopigmentary Effects of Ethyl P-Methoxycinnamate Isolated from Kaempferia galanga

      Hyun-Ju Ko, Hae Jong Kim, Su Yeon Kim, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Wan Kyun Whang, Hye-Ryung Choi, Kyoung-Chan Park and Dong-Seok Kim

      Article first published online: 23 APR 2013 | DOI: 10.1002/ptr.4995

  9. Full Papers

    1. Modulatory Effects of Quercetin and Rutin on the Activity, Expression and Inducibility of CYP1A1 in Intestinal HCT-8 Cells

      M. Volková, V. Forstová-Křížová, L. Skálová and F. Trejtnar

      Article first published online: 23 APR 2013 | DOI: 10.1002/ptr.4992

  10. Research Articles

    1. Momordica charantia Ameliorates Insulin Resistance and Dyslipidemia with Altered Hepatic Glucose Production and Fatty Acid Synthesis and AMPK Phosphorylation in High-fat-fed Mice

      Chun-Ching Shih, Min-Tzong Shlau, Cheng-Hsiu Lin and Jin-Bin Wu

      Article first published online: 23 APR 2013 | DOI: 10.1002/ptr.5003

    2. Hypolipidemic Activity of Okra is Mediated Through Inhibition of Lipogenesis and Upregulation of Cholesterol Degradation

      Hong Wang, Gu Chen, Dandan Ren and Shang-Tian Yang

      Article first published online: 22 APR 2013 | DOI: 10.1002/ptr.4998

    3. Ficus carica Leaf Extract Modulates the Lipid Profile of Rats Fed with a High-Fat Diet through an Increase of HDL-C

      Lorenz Joerin, Michaela Kauschka, Bernd Bonnländer, Ivo Pischel, Birgit Benedek and Veronika Butterweck

      Article first published online: 22 APR 2013 | DOI: 10.1002/ptr.4994

    4. Protective Effects of HemoHIM on Immune and Hematopoietic Systems Against γ-Irradiation

      Hae-Ran Park, Sung-Kee Jo, Uhee Jung, Sung-Tae Yee and Sung-Ho Kim

      Article first published online: 18 APR 2013 | DOI: 10.1002/ptr.4982

    5. Pine Oil Effects on Chemical and Thermal Injury in Mice and Cultured Mouse Dorsal Root Ganglion Neurons

      S. P. Clark, W. B. Bollag, K. N. Westlund, F. Ma, G. Falls, D. Xie, M. Johnson, C. M. Isales and M. H. Bhattacharyya

      Article first published online: 18 APR 2013 | DOI: 10.1002/ptr.4991

  11. Short Communications

    1. Palbinone from Paeonia suffruticosa Protects Hepatic Cells via Up-regulation of Heme Oxygenase-1

      Do Thi Ha, Tran Thi Phuong, Joonseok Oh, KiHwan Bae, Nguyen Duy Thuan and MinKyun Na

      Article first published online: 18 APR 2013 | DOI: 10.1002/ptr.4993

    2. Quinolone Alkaloids from Fructus Euodiae Show Activity Against Methicillin-Resistant Staphylococcus aureus

      Xiaobei Pan, S. W. Annie Bligh and Eileen Smith

      Article first published online: 15 APR 2013 | DOI: 10.1002/ptr.4987

  12. Research Articles

    1. Anti-asthmatic Effects of Baicalin in a Mouse Model of Allergic Asthma

      Chunhua Ma, Zhangqiang Ma, Qiang Fu and Shiping Ma

      Article first published online: 11 APR 2013 | DOI: 10.1002/ptr.4983

    2. Decursin Exerts Anti-cancer Activity in MDA-MB-231 Breast Cancer Cells Via Inhibition of the Pin1 Activity and Enhancement of the Pin1/p53 Association

      Ji-Hyun Kim, Ji Hoon Jung, Sung-Hoon Kim and Soo-Jin Jeong

      Article first published online: 11 APR 2013 | DOI: 10.1002/ptr.4986

    3. Fucoidan Prevents High-Fat Diet-Induced Obesity in Animals by Suppression of Fat Accumulation

      Mi-Ja Kim, Joseph Jeon and Jin-Sil Lee

      Article first published online: 11 APR 2013 | DOI: 10.1002/ptr.4965

    4. Anti-Ulcerative Colitis Activity of Compounds from Euphorbia granuleta Forssk

      Amani S. Awaad, Reham M. El-Meligy, Nabila A. Al-Jaber, Hanoof S. Al-Muteeri, Mohamed E. Zain, Saleh I. Alqasoumi, Ahmed M. Alafeefy and Abd El Raheim M. Donia

      Article first published online: 11 APR 2013 | DOI: 10.1002/ptr.4985

    5. In Vitro Inhibition of the Transcription Factor NF-κB and Cyclooxygenase by Bamboo Extracts

      Laura Van Hoyweghen, Karolien De Bosscher, Guy Haegeman, Dieter Deforce and Arne Heyerick

      Article first published online: 5 APR 2013 | DOI: 10.1002/ptr.4978

  13. Reviews

    1. Animal Studies on Medicinal Herbs: Predictability, Dose Conversion and Potential Value

      Ken Wojcikowski and Glenda Gobe

      Article first published online: 4 APR 2013 | DOI: 10.1002/ptr.4966

  14. Research Articles

    1. Impact of Phytolacca americana Extracts on Gene Expression of Colon Cancer Cells

      L. Maness, I. Goktepe, H. Chen, M. Ahmedna and S. Sang

      Article first published online: 3 APR 2013 | DOI: 10.1002/ptr.4979

  15. Short Communications

    1. A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner

      Gabriella Aviello, Sylvie Amu, Sean P. Saunders and Padraic G. Fallon

      Article first published online: 3 APR 2013 | DOI: 10.1002/ptr.4989

  16. Research Articles

    1. Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol-XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals

      Constantin Dallas, Alain Gerbi, Yves Elbez, Philippe Caillard, Nicolas Zamaria and Maurice Cloarec

      Article first published online: 3 APR 2013 | DOI: 10.1002/ptr.4981

  17. Short Communications

    1. Furanodiene Presents Synergistic Anti-proliferative Activity With Paclitaxel Via Altering Cell Cycle and Integrin Signaling in 95-D Lung Cancer Cells

      Wen-Shan Xu, Yuan-Ye Dang, Xiu-Ping Chen, Jin-Jian Lu and Yi-Tao Wang

      Article first published online: 3 APR 2013 | DOI: 10.1002/ptr.4984

  18. Research Articles

    1. p-Coumaric Acid Activates the GABA-A Receptor In Vitro and is Orally Anxiolytic In Vivo

      Arjan Scheepens, Jean-Francois Bisson and Margot Skinner

      Article first published online: 26 MAR 2013 | DOI: 10.1002/ptr.4968

    2. Multiple Phytoestrogens Inhibit Cell Growth and Confer Cytoprotection By Inducing Manganese Superoxide Dismutase Expression

      Ellen L. Robb and Jeffrey A. Stuart

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4970

    3. Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects

      Sedigheh Asgary, Amirhossein Sahebkar, Mohammad Reza Afshani, Mahtab Keshvari, Shaghayegh Haghjooyjavanmard and Mahmoud Rafieian-Kopaei

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4977

    4. Antagonism by Ganoderma lucidum Polysaccharides Against the Suppression by Culture Supernatants of B16F10 Melanoma Cells on Macrophage

      Jie Lu, Li-Xin Sun, Zhi-Bin Lin, Xin-Suo Duan, Zhi-Hua Ge, En-Hong Xing, Tian-Fei Lan, Ning Yang, Xue-Jun Li, Min Li and Wei-Dong Li

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4980

    5. 6-Gingerol Inhibits Rosiglitazone-Induced Adipogenesis in 3T3-L1 Adipocytes

      Thing-Fong Tzeng, Chia Ju Chang and I-Min Liu

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4976

  19. Reviews

    1. A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis

      Xue Zhang, Yan-Long Hong, De-Sheng Xu, Yi Feng, Li-Jie Zhao, Ke-Feng Ruan and Xiu-Juan Yang

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4960

  20. Research Articles

    1. Treatment of Primary Chronic Glomerulonephritis with Rehmannia Glutinosa Acteosides in Combination with the Angiotensin Receptor Blocker Irbesartan: A Randomized Controlled Trial

      HongYu Qiu, Ping Fu, WenXing Fan, Chuan Zuo, Ping Feng, Peng Shi, Lina Cao, Fang Liu, Li Zhou, Feng Chen, Hui Zhong, ZhongPing Gou, YaPing Liang and Mei Shi

      Article first published online: 21 MAR 2013 | DOI: 10.1002/ptr.4973

    2. Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa

      Yamin Jia, Qiunong Guan, Yong Jiang, Baljinder Salh, Yuhai Guo, Pengfei Tu and Caigan Du

      Article first published online: 20 MAR 2013 | DOI: 10.1002/ptr.4967

    3. Neuroprotective Effects of Puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's Disease Model in Mice

      Guoqi Zhu, Xuncui Wang, Shengbing Wu, Xiaoxiang Li and Qinglin Li

      Article first published online: 20 MAR 2013 | DOI: 10.1002/ptr.4975

    4. Efficacy and Safety of Standardized Extract of Trigonella foenum-graecum L Seeds as an Adjuvant to L-Dopa in the Management of Patients with Parkinson's Disease

      J. Nathan, Siddika Panjwani, V. Mohan, Veena Joshi and Prasad Arvind Thakurdesai

      Article first published online: 19 MAR 2013 | DOI: 10.1002/ptr.4969

    5. Effect of the Potent Antiviral 1-Cinnamoyl-3,11-Dihydroxymeliacarpin on Cytokine Production by Murine Macrophages Stimulated with HSV-2

      Erina Petrera and Celia E. Coto

      Article first published online: 19 MAR 2013 | DOI: 10.1002/ptr.4974

    6. Epigallocatechin-3-Gallate Inhibits Collagen Production of Nasal Polyp-Derived Fibroblasts

      Jae Seong Kang, Il-Ho Park, Jung-Sun Cho, Sung-Moon Hong, Tae Hoon Kim, Sang Hag Lee and Heung-Man Lee

      Article first published online: 19 MAR 2013 | DOI: 10.1002/ptr.4971

    7. A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB-Induced Skin Photoaging in vitro

      Eunson Hwang, Su Hyeon Kim, Sarah Lee, Choong Hwan Lee, Seon-Gil Do, Jinwan Kim and Sun Yeou Kim

      Article first published online: 15 MAR 2013 | DOI: 10.1002/ptr.4943

  21. Reviews

    1. The Role of Traditional Chinese Medicines in Osteogenesis and Angiogenesis

      Yanqi Yang, Alice Chin, Linkun Zhang, Jiajing Lu and Ricky Wing Kit Wong

      Article first published online: 15 MAR 2013 | DOI: 10.1002/ptr.4959

  22. Research Articles

    1. Curcuminoids Modulate Pro-Oxidant–Antioxidant Balance but not the Immune Response to Heat Shock Protein 27 and Oxidized LDL in Obese Individuals

      Amirhossein Sahebkar, Akram Mohammadi, Ali Atabati, Shamim Rahiman, Shima Tavallaie, Mehrdad Iranshahi, Saeed Akhlaghi, Gordon AA Ferns and Majid Ghayour-Mobarhan

      Article first published online: 15 MAR 2013 | DOI: 10.1002/ptr.4952

  23. Reviews

    1. Raphanus sativus L. var niger as a source of Phytochemicals for the Prevention of Cholesterol Gallstones

      Ibrahim Guillermo Castro-Torres, Minarda De la O-Arciniega, Janeth Gallegos-Estudillo, Elia Brosla Naranjo-Rodríguez and Miguel Ángel Domínguez-Ortíz

      Article first published online: 15 MAR 2013 | DOI: 10.1002/ptr.4964

  24. Research Articles

    1. Protective Effects of Total Flavonoids from Epimedium on the Male Mouse Reproductive System Against Cyclophosphamide-Induced Oxidative Injury by Up-Regulating the Expressions of SOD3 and GPX1

      Ding Yuan, Hongwu Wang, Haibo He, Liangliang Jia, Yumin He, Ting Wang, Xiao Zeng, Yuzhou Li, Shouchao Li and Changcheng Zhang

      Article first published online: 12 MAR 2013 | DOI: 10.1002/ptr.4956

    2. Ascorbigen Induces Dermal Papilla Cell Proliferation in Vitro, but Fails to Modulate Chemotherapy-Induced Alopecia in Vivo

      Chih-Hsiu Wang, Hsu-Shan Huang, Niann-Tzyy Dai, Ming-Jen Sheu and Deh-Ming Chang

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4933

  25. Reviews

    1. Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: A Review

      Bin Du, Zhaoxiang Bian and Baojun Xu

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4963

  26. Research Articles

    1. Anti-biofilm Effects of Honey Against Wound Pathogens Proteus mirabilis and Enterobacter cloacae

      Juraj Majtan, Jana Bohova, Miroslava Horniackova, Jaroslav Klaudiny and Viktor Majtan

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4957

    2. In vitro Antimicrobial Activity of Royleanone Derivatives Against Gram-Positive Bacterial Pathogens

      Patrícia Rijo, Aida Duarte, Ana Paula Francisco, Teresa Semedo-Lemsaddek and Maria Fátima Simões

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4961

    3. Assessment of Cytotoxic Properties of Safranal and Nanoliposomal Safranal in Various Cancer Cell Lines

      Bizhan Malaekeh-Nikouei, Seyed Hadi Mousavi, Shabnam Shahsavand, Soghra Mehri, Horiyeh Nassirli and Seyed Adel Moallem

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4945

    4. Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium Chloride in Rats

      Ankica Jelenković, Marina D. Jovanović, Ivana Stevanović, Nataša Petronijević, Dubravko Bokonjić, Jelena Živković and Rajko Igić

      Article first published online: 11 MAR 2013 | DOI: 10.1002/ptr.4962

    5. Inhibition of TNF-α-Induced MUC5AC Mucin Gene Expression and Production by Wogonin Through the Inactivation of NF-κB Signaling in Airway Epithelial Cells

      Md. Asaduzzaman Sikder, Hyun Jae Lee, Md. Zakaria Mia, Su Hyun Park, Jiho Ryu, Jang-Hyun Kim, Sang Yeon Min, Jang-Hee Hong, Jeong Ho Seok and Choong Jae Lee

      Article first published online: 6 MAR 2013 | DOI: 10.1002/ptr.4954

    6. Chunggan Extract (CGX), A Traditional Korean Herbal Medicine, Exerts Hepatoprotective Effects in a Rat Model of Chronic Alcohol Consumption

      Hyeong Geug Kim, Jing Hua Wang, Jong Min Han, Seok Yeon Hwang, Dong Soo Lee and Chang Gue Son

      Article first published online: 4 MAR 2013 | DOI: 10.1002/ptr.4935

    7. Evaluation of the Effect of Beetroot Juice on DMBA-induced Damage in Liver and Mammary Gland of Female Sprague–Dawley Rats

      Hanna Szaefer, Violetta Krajka-Kuźniak, Ewa Ignatowicz, Teresa Adamska and Wanda Baer-Dubowska

      Article first published online: 1 MAR 2013 | DOI: 10.1002/ptr.4951

  27. Short Communications

    1. Comparative Pharmacokinetic Study of Chlorogenic Acid after Oral Administration of Lonicerae Japonicae Flos and Shuang-Huang-Lian in Normal and Febrile Rats

      Ru Gao, Yining Lin, Ge Liang, Boyang Yu and Yuan Gao

      Article first published online: 28 FEB 2013 | DOI: 10.1002/ptr.4958

  28. Research Articles

    1. Identification of Kazinol Q, a Natural Product from Formosan Plants, as an Inhibitor of DNA Methyltransferase

      Jing-Ru Weng, I-Lu Lai, Hsiao-Ching Yang, Chun-Nan Lin and Li-Yuan Bai

      Article first published online: 28 FEB 2013 | DOI: 10.1002/ptr.4955

    2. Linalool-rich Rosewood Oil Induces Vago-vagal Bradycardic and Depressor Reflex in Rats

      Rodrigo José de Siqueira, Karilane Maria Silvino Rodrigues, Moisés Tolentino Bento da Silva, Carlos Antônio Barros Correia Junior, Gloria Pinto Duarte, Pedro Jorge Caldas Magalhães, Armênio Aguiar dos Santos, José Guilherme Soares Maia, Pergentino José Sousa da Cunha and Saad Lahlou

      Article first published online: 27 FEB 2013 | DOI: 10.1002/ptr.4953

  29. Short Communications

    1. Antiplatelet Activity of a Novel Formula Composed of Malic Acid, Succinic Acid and Citric Acid from Cornus officinalis Fruit

      Qi-Chun Zhang, Yue Zhao and Hui-Min Bian

      Article first published online: 27 FEB 2013 | DOI: 10.1002/ptr.4934

  30. Research Articles

    1. Metabolic Management in Overweight Subjects with Naive Impaired Fasting Glycaemia by Means of a Highly Standardized Extract From Cynara scolymus: A Double-blind, Placebo-controlled, Randomized Clinical Trial

      Mariangela Rondanelli, Annalisa Opizzi, Milena Faliva, Patrizio Sala, Simone Perna, Antonella Riva, Paolo Morazzoni, Ezio Bombardelli and Attilio Giacosa

      Article first published online: 25 FEB 2013 | DOI: 10.1002/ptr.4950

    2. Blood Pressure Lowering Effect of Nigella sativa L. Seed Oil in Healthy Volunteers: A Randomized, Double-Blind, Placebo-controlled Clinical Trial

      H. Fallah Huseini, M. Amini, R. Mohtashami, M. E. Ghamarchehre, Z. Sadeqhi, S. Kianbakht and A. Fallah Huseini

      Article first published online: 25 FEB 2013 | DOI: 10.1002/ptr.4944

    3. Extracts from Epilobium sp. Herbs, Their Components and Gut Microbiota Metabolites of Epilobium Ellagitannins, Urolithins, Inhibit Hormone-Dependent Prostate Cancer Cells-(LNCaP) Proliferation and PSA Secretion

      Magdalena Stolarczyk, Jakub P. Piwowarski, Sebastian Granica, Joanna Stefańska, Marek Naruszewicz and Anna K. Kiss

      Article first published online: 25 FEB 2013 | DOI: 10.1002/ptr.4941

    4. Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

      Eliziane Mieko Konta, Mara Ribeiro Almeida, Cátia Lira do Amaral, Joana Darc Castania Darin, Veridiana V. de Rosso, Adriana Zerlotti Mercadante, Lusânia Maria Greggi Antunes and Maria Lourdes Pires Bianchi

      Article first published online: 25 FEB 2013 | DOI: 10.1002/ptr.4949

  31. Reviews

    1. Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview

      Jue Zhou, Moustapha Ouedraogo, Fan Qu and Pierre Duez

      Article first published online: 19 FEB 2013 | DOI: 10.1002/ptr.4942

  32. Research Articles

    1. The Phytoestrogenic Compound Cajanol from Pigeonpea Roots is Associated with the Activation of Estrogen Receptor α-dependent Signaling Pathway in Human Prostate Cancer Cells

      Lu Liang, Chang Gao, Meng Luo, Chunjian Zhao, Wei Wang, Chengbo Gu, Jinghua Yu and Yujie Fu

      Article first published online: 19 FEB 2013 | DOI: 10.1002/ptr.4937

    2. Anti-depressant Effects of Aqueous Extract from Acanthopanax senticosus in Mice

      Liji Jin, Feifei Wu, Xiaoyu Li, Huaqiang Li, Chong Du, Qi Jiang, Jiansong You, Shuying Li and Yongping Xu

      Article first published online: 18 FEB 2013 | DOI: 10.1002/ptr.4938

    3. Caffeoylserotonin Protects Human Keratinocyte HaCaT Cells against H2O2-Induced Oxidative Stress and Apoptosis through Upregulation of HO-1 Expression via Activation of the PI3K/Akt/Nrf2 Pathway

      Cam Ngoc Nguyen, Hye-Eun Kim and Seong-Gene Lee

      Article first published online: 17 FEB 2013 | DOI: 10.1002/ptr.4931

  33. Reviews

    1. Traditional Chinese Medicine and Western Psychopharmacology: Building Bridges

      Edward Shorter and Kathryn Segesser

      Article first published online: 17 FEB 2013 | DOI: 10.1002/ptr.4940

  34. Research Articles

    1. A Biochemical and Cellular Approach to Explore the Antiproliferative and Prodifferentiative Activity of Aloe Arborescens Leaf Extract

      Blanda Di Luccia, Nicola Manzo, Maria Vivo, Eugenio Galano, Angela Amoresano, Elvira Crescenzi, Alessandra Pollice, Raffaella Tudisco, Federico Infascelli and Viola Calabrò

      Article first published online: 17 FEB 2013 | DOI: 10.1002/ptr.4939

    2. The Lignan (-)-Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta

      Marco Túlio Menezes Carvalho, Karen Cristina Souza Rezende, Paulo Roberto Barbosa Evora, Jairo Kenupp Bastos, Wilson Roberto Cunha, Marcio Luis Andrade e Silva and Andréa Carla Celotto

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4932

    3. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on Phenytoin Pharmacokinetics in Beagle Dogs

      Khalid M. Alkharfy, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Saleh A. Al-Suwayeh, Rao M. A. Khan and Ajaz Ahmad

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4947

    4. [6]-Shogaol Attenuates Neuronal Apoptosis in Hydrogen Peroxide-Treated Astrocytes Through the Up-Regulation of Neurotrophic Factors

      Sokho Kim and Jungkee Kwon

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4946

    5. The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell-Induced Bone Destruction

      Sun Kyoung Lee, Kwang-Kyun Park, Jung Han Yoon Park, Soon Sung Lim and Won-Yoon Chung

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4930

    6. In vivo Antimalarial Activity of a Labdane Diterpenoid from the Leaves of Otostegia integrifolia Benth

      Abyot Endale, Daniel Bisrat, Abebe Animut, Franz Bucar and Kaleab Asres

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4948

    7. Fangchinoline Induces G1 Arrest in Breast Cancer Cells Through Cell-Cycle Regulation

      Zhibo Xing, Youxue Zhang, Xianyu Zhang, Yanmei Yang, Yuyan Ma and Da Pang

      Article first published online: 11 FEB 2013 | DOI: 10.1002/ptr.4936

    8. Neuroprotective Effects of Formononetin Against NMDA-Induced Apoptosis in Cortical Neurons

      Zhen Tian, Shui-bing Liu, Yu-cai Wang, Xiao-qiang Li, Lian-he Zheng and Ming-gao Zhao

      Article first published online: 30 JAN 2013 | DOI: 10.1002/ptr.4928

    9. Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

      G. Belcaro, U. Cornelli, R. Luzzi, M. R. Cesarone, M. Dugall, B. Feragalli, S. Errichi, E. Ippolito, M. G. Grossi, M. Hosoi, M. Cornelli and G. Gizzi

      Article first published online: 28 JAN 2013 | DOI: 10.1002/ptr.4883

    10. Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects

      J Sarris, C Stough, R Teschke, ZT Wahid, CA Bousman, G Murray, KM Savage, P Mouatt, C Ng and I Schweitzer

      Article first published online: 24 JAN 2013 | DOI: 10.1002/ptr.4916

    11. Prunella vulgaris Attenuates Prepulse Inhibition Deficit and Attention Disruption induced by MK-801 in Mice

      Se Jin Park, Se Jin Jeon, Ike C. dela Peña, Hyung Eun Lee, Dong Hyun Kim, Jong Min Kim, Young Woo Lee, Jun Man Jung, Bum Young Shin, Seungheon Lee, Jae Hoon Cheong, Chan Young Shin, Dae Sik Jang and Jong Hoon Ryu

      Article first published online: 24 JAN 2013 | DOI: 10.1002/ptr.4929

    12. The Inhibitory Effects of the Standardized Extracts of Ginkgo biloba on Aromatase Activity in JEG-3 Human Choriocarcinoma Cells

      Mi Jie Kim, Yong Joo Park, Kyu Hyuck Chung and Seung Min Oh

      Article first published online: 21 JAN 2013 | DOI: 10.1002/ptr.4927

    13. Inhibiting Roles of Berberine in Gut Movement of Rodents are Related to Activation of the Endogenous Opioid System

      Yajing Feng, Yongyu Li, Chunqiu Chen, Xuhong Lin, Yuehua Yang, Haidong Cai, Zhongwei Lv, Minghua Cao, Kun Li, Jing Xu, Sainan Li and Yijun Jia

      Article first published online: 21 JAN 2013 | DOI: 10.1002/ptr.4926

  35. Full Papers

    1. Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 β Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells

      Hyun-Soo Son, Hee Young Kwon, Eun Jung Sohn, Jang-Hoon Lee, Hong-Jung Woo, Miyong Yun, Sung-Hoon Kim and Young-Chul Kim

      Article first published online: 16 JAN 2013 | DOI: 10.1002/ptr.4925

  36. Book Reviews

    1. Medicinal Plants of China, Korea and Japan. Bioesources for Tomorrow's Drugs and Cosmetics. C Wiart. CRC Press, US. ISBN 978-4398-9911-3 (Hardback) $US149.95. pp432

      Elizabeth M Williamson

      Article first published online: 14 JAN 2013 | DOI: 10.1002/ptr.4922

  37. Research Articles

    1. Phytotherapeutic Management of Polycystic Ovary Syndrome: Role of Aerial Parts of Wood Betony (Stachys lavandulifolia)

      Nasrin Jalilian, Masoud Modarresi, Mansour Rezaie, Leila Ghaderi and Mohammadreza Bozorgmanesh

      Article first published online: 11 JAN 2013 | DOI: 10.1002/ptr.4921

    2. Anti-platelet Activity of Erythro-(7S,8R)-7-acetoxy-3,4,3`,5`-tetramethoxy-8-O-4`-neolignan from Myristica fragrans

      Jung Won Kang, Byung-Sun Min and Jeong-Hyung Lee

      Article first published online: 8 JAN 2013 | DOI: 10.1002/ptr.4923

    3. Eupatolide Inhibits PDGF-induced Proliferation and Migration of Aortic Smooth Muscle Cells Through ROS-dependent Heme Oxygenase-1 Induction

      Namho Kim, Cheol Hwangbo, Suhyun Lee and Jeong-Hyung Lee

      Article first published online: 8 JAN 2013 | DOI: 10.1002/ptr.4924

    4. Effect of Wine Polyphenol Resveratrol on the Contractions Elicited Electrically or by Norepinephrine in the Rat Portal Vein

      Dragana Protić, Bojana Beleslin-Čokić, Radmila Novaković, Vladimir Kanjuh, Helmut Heinle, Radisav Šćepanović and Ljiljana Gojković-Bukarica

      Article first published online: 8 JAN 2013 | DOI: 10.1002/ptr.4907

    5. Chrysin and Luteolin Attenuate Diabetes-Induced Impairment in Endothelial-Dependent Relaxation: Effect on Lipid Profile, AGEs and NO Generation

      Hany M. El-Bassossy, Shaymaa M. Abo-Warda and Ahmed Fahmy

      Article first published online: 7 JAN 2013 | DOI: 10.1002/ptr.4917

    6. Antioxidant and In Vitro Anticancer Effect of 2-Pyrrolidinone Rich Fraction of Brassica oleracea var. capitata Through Induction of Apoptosis in Human Cancer Cells

      Ramar Thangam, Veeraperumal Suresh, Mayan Rajkumar, Jally Damien Vincent, Palani Gunasekaran, Chinnathambi Anbazhagan, Krishnasamy Kaveri and Soundarapandian Kannan

      Article first published online: 4 JAN 2013 | DOI: 10.1002/ptr.4908

    7. Mechanisms of Andrographolide-Induced Platelet Apoptosis in Human Platelets: Regulatory Roles of the Extrinsic Apoptotic Pathway

      Li-Ming Lien, Cheng-Chen Su, Wen-Hsien Hsu, Wan-Jung Lu, Chi-Li Chung, Ting-Lin Yen, Hou-Chang Chiu, Joen-Rong Sheu and Kuan-Hung Lin

      Article first published online: 4 JAN 2013 | DOI: 10.1002/ptr.4911

  38. Short Communications

    1. Potentiating Effect of the Flavonolignan (-)-Hydnocarpin in Combination with Vincristine in a Sensitive and P-gp-Expressing Acute Lymphoblastic Leukemia Cell Line

      Lynette Bueno Pérez, Li Pan, Ellen Sass, Sneha V. Gupta, Amy Lehman, A. Douglas Kinghorn and David M. Lucas

      Article first published online: 28 DEC 2012 | DOI: 10.1002/ptr.4903

  39. Reviews

    1. Prebiotics to Fight Diseases: Reality or Fiction?

      F. Di Bartolomeo, J.B. Startek and W. Van den Ende

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4901

  40. Research Articles

    1. Standardized Aqueous Tribulus terristris (Nerunjil) Extract Attenuates Hyperalgesia in Experimentally Induced Diabetic Neuropathic Pain Model: Role of Oxidative Stress and Inflammatory Mediators

      Ravichandran Ranjithkumar, S. Prathab Balaji, Bhaskar Balaji, R V Ramesh and Muthiah Ramanathan

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4915

    2. Antifungal Activity of 10 Guadeloupean Plants

      Murielle Biabiany, Vincent Roumy, Thierry Hennebelle, Nadine François, Boualem Sendid, Muriel Pottier, El Moukhtar Aliouat, Isabelle Rouaud, Françoise Lohézic-Le Dévéhat, Henry Joseph, Paul Bourgeois, Sevser Sahpaz and François Bailleul

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4906

    3. Protective Effects of Quercetin on Streptozotocin-induced Diabetic Nephropathy in Rats

      Hui-hui Hao, Qian Lu, Dao-quan Tang, Zhu-min Shao, Xiao-xing Yin, Jie Mou and Qian Du

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4910

  41. Reviews

    1. Emerging Importance of Geographical Indications and Designations of Origin – Authenticating Geo-Authentic Botanicals and Implications for Phytotherapy

      J. A. Brinckmann

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4912

  42. Research Articles

    1. Anti-Adipogenic Activity of Berberine is Not Mediated by the WNT/β-Catenin Pathway

      Sungmin Bae and Yoosik Yoon

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4918

    2. Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop

      Mirjana Marčetić, Dragana Božić, Marina Milenković, Nevenka Malešević, Siniša Radulović and Nada Kovačević

      Article first published online: 27 DEC 2012 | DOI: 10.1002/ptr.4919

    3. Houttuynia cordata Thunb. Volatile Oil Exhibited Anti-inflammatory Effects In Vivo and Inhibited Nitric Oxide and Tumor Necrosis Factor-α Production in LPS-stimulated Mouse Peritoneal Macrophages In Vitro

      Weifeng Li, Ting Fan, Yanmin Zhang, Te Fan, Ping Zhou, Xiaofeng Niu and Langchong He

      Article first published online: 20 DEC 2012 | DOI: 10.1002/ptr.4905

    4. A Comparative Study on the Inhibitory Effects of Different Parts and Chemical Constituents of Pomegranate on α-Amylase and α-Glucosidase

      Antony Kam, Kong M. Li, Valentina Razmovski-Naumovski, Srinivas Nammi, Jeffrey Shi, Kelvin Chan and George Q. Li

      Article first published online: 19 DEC 2012 | DOI: 10.1002/ptr.4913

    5. The Neurocognitive Effects of Hypericum perforatum Special Extract (Ze 117) during Smoking Cessation

      D.A. Camfield, A.B. Scholey, A. Pipingas, R.B. Silberstein, C. Kure, A. Zangara, M. Kras and C. Stough

      Article first published online: 19 DEC 2012 | DOI: 10.1002/ptr.4909

    6. A Metabonomic Approach to a Unique Detoxification Effect of Co-use of Euphorbia kansui and Zizyphus jujuba

      Yu-Mei Liu, Rong-Rong Hui, Cui-Cui He, Jin-Ao Duan, Yu-Ping Tang and Jian-Xin Li

      Article first published online: 19 DEC 2012 | DOI: 10.1002/ptr.4914

    7. An Acute, Double-Blind, Placebo-Controlled Crossover Study of 320 mg and 640 mg Doses of a Special Extract of Bacopa monnieri (CDRI 08) on Sustained Cognitive Performance

      Luke A. Downey, James Kean, Fiona Nemeh, Angela Lau, Alex Poll, Rebecca Gregory, Margaret Murray, Johanna Rourke, Brigit Patak, Matthew P. Pase, Andrea Zangara, Justine Lomas, Andrew Scholey and Con Stough

      Article first published online: 19 DEC 2012 | DOI: 10.1002/ptr.4864

  43. Reviews

    1. Coriander (Coriandrum sativum L.): A Potential Source of High-Value Components for Functional Foods and Nutraceuticals- A Review

      Najla Gooda Sahib, Farooq Anwar, Anwarul-Hassan Gilani, Azizah Abdul Hamid, Nazamid Saari and Khalid M. Alkharfy

      Article first published online: 19 DEC 2012 | DOI: 10.1002/ptr.4897

  44. Research Articles

    1. The Multi-Targeted Effects of Chrysanthemum Herb Extract Against Escherichia coli O157:H7

      Ki-Suk Kim, Dong Jin Lim, Hea Jung Yang, Eun-Kyeong Choi, Min Hee Shin, Kwang Seok Ahn, Sang Hoon Jung, Jae Young Um, Hee-Jae Jung, Jun Hee Lee, Seok-Geun Lee, Sung-Ki Jung and Hyeung-Jin Jang

      Article first published online: 17 DEC 2012 | DOI: 10.1002/ptr.4859

    2. Antinociceptive Effect of Lupeol: Evidence for a Role of Cytokines Inhibition

      Flávia Oliveira de Lima, Vivian Alves, José Maria Barbosa Filho, Jackson Roberto Guedes da Silva Almeida, Luis Cezar Rodrigues, Milena Botelho Pereira Soares and Cristiane Flora Villarreal

      Article first published online: 3 DEC 2012 | DOI: 10.1002/ptr.4902

  45. Errata

    1. An Extract of Withania somnifera Attenuates Endothelin-1-stimulated Pigmentation in Human Epidermal Equivalents through the Interruption of PKC Activity Within Melanocytes

      Hiroaki Nakajima, Yuki Wakabayashi, Kazumasa Wakamatsu and Genji Imokawa

      Article first published online: 3 DEC 2012 | DOI: 10.1002/ptr.4904

  46. Research Articles

    1. Effects of Piperine, Cinnamic Acid and Gallic Acid on Rosuvastatin Pharmacokinetics in Rats

      Sudipta Basu, Snehasis Jana, Vandana B. Patel and Hitesh Patel

      Article first published online: 3 DEC 2012 | DOI: 10.1002/ptr.4894

    2. Rhodiola-Water Extract Induces β-endorphin Secretion to Lower Blood Pressure in Spontaneously Hypertensive Rats

      Wei-Jing Lee, Hsien-Hui Chung, Yung-Ze Cheng, Hung Jung Lin and Juei-Tang Cheng

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4900

    3. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players

      Ivana Baralic, Brizita Djordjevic, Nenad Dikic, Jelena Kotur-Stevuljevic, Slavica Spasic, Zorana Jelic-Ivanovic, Nenad Radivojevic, Marija Andjelkovic and Snezana Pejic

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4898

    4. Pimarane-type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram-positive Multidrug-resistant Bacteria

      Thiago S. Porto, Marília R. Simão, Lucas Z. Carlos, Carlos H. G. Martins, Niege A. J. C. Furtado, Suraia Said, Nilton S. Arakawa, Raquel A. dos Santos, Rodrigo C. S. Veneziani and Sérgio R. Ambrósio

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4887

    5. Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors

      Xiao-Feng Yan, Zhong-Miao Zhang, Hong-Yi Yao, Yan Guan, Jian-Ping Zhu, Lin-Hui Zhang, Yong-Liang Jia and Ru-Wei Wang

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4899

  47. Short Communications

    1. Apoptosis-inducing and Antitumor Activity of Neolignans Isolated from Magnolia officinalis in HeLa Cancer Cells

      Ui Joung Youn, Nighat Fatima, Quan Cheng Chen, Sungwook Chae, Tran Manh Hung and Byung-Sun Min

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4893

  48. Research Articles

    1. Scutellarin-Induced Apoptosis in HepG2 Hepatocellular Carcinoma Cells Via a STAT3 Pathway

      Haitao Xu and Songyan Zhang

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4892

    2. Effect of Corilagin on Membrane Permeability of Escherichia coli, Staphylococcus aureus and Candida albicans

      Na Li, Meng Luo, Yu-jie Fu, Yuan-gang Zu, Wei Wang, Lin Zhang, Li-ping Yao, Chun-jian Zhao and Yu Sun

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4891

    3. Chemical and Biological Characterization of Novel Essential Oils from Eremophila bignoniiflora (F. Muell) (Myoporaceae): a Traditional Aboriginal Australian Bush Medicine

      Nicholas John Sadgrove, Maria Hitchcock, Kenneth Watson and Graham Lloyd Jones

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4889

    4. A Natural Antioxidant Pine Bark Extract, Oligopin®, Regulates the Stress Chaperone HSPB1 in Human Skeletal Muscle Cells: A Proteomics Approach

      Sylvie Poussard, Amélie Pires-Alves, Ramata Diallo, Jean-William Dupuy and Elise Dargelos

      Article first published online: 28 NOV 2012 | DOI: 10.1002/ptr.4895

    5. In Vitro Characterization of Glucuronidation of Vanillin: Identification of Human UDP-Glucuronosyltransferases and Species Differences

      Jian Yu, Jing-Chun Han, Li-Min Hua and Ya-Jie Gao

      Article first published online: 26 NOV 2012 | DOI: 10.1002/ptr.4885

    6. Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats

      Su-xiang Feng, Jian-sheng Li, Ling-bo Qu, Yan-mei Shi and Di Zhao

      Article first published online: 26 NOV 2012 | DOI: 10.1002/ptr.4890

    7. Genotoxic and Antigenotoxic Activity of Acerola (Malpighia glabra L.) Extract in Relation to the Geographic Origin

      Roberta Da Silva Nunes, Vivian Francília Silva Kahl, Merielen Da Silva Sarmento, Marc François Richter, Juan Andres Abin-Carriquiry, Marcela María Martinez, Alexandre De Barros Falcão Ferraz and Juliana Da Silva

      Article first published online: 26 NOV 2012 | DOI: 10.1002/ptr.4896

    8. Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin

      Ho Young Kim, Sung Keun Jung, Sanguine Byun, Joe Eun Son, Mi Hyun Oh, Jihoon Lee, Min Jeong Kang, Yong-Seok Heo, Ki Won Lee and Hyong Joo Lee

      Article first published online: 21 NOV 2012 | DOI: 10.1002/ptr.4888

    9. Glycyrrhiza uralensis Flavonoids Present in Anti-Asthma Formula, ASHMITM, Inhibit Memory Th2 Responses in Vitro and in Vivo

      Nan Yang, Sangita Patil, Jian Zhuge, Ming-Chun Wen, Jayaprakasam Bolleddula, Srinivasulu Doddaga, Joseph Goldfarb, Hugh A. Sampson and Xiu-Min Li

      Article first published online: 19 NOV 2012 | DOI: 10.1002/ptr.4862

    10. Rhizome of Anemarrhena Asphodeloides Counteracts Diabetic Ophthalmopathy Progression in Streptozotocin-Induced Diabetic Rats

      Xuan Li, Xiaobing Cui, Jinjin Wang, Jie Yang, Xiaoyu Sun, Xiaodong Li, Quan Zhu and Wei Li

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4866

    11. Pharmacokinetics of Hesperetin and Naringenin in the Zhi Zhu Wan, a Traditional Chinese Medicinal Formulae, and its Pharmacodynamics Study

      Hui Sun, Tianwei Dong, Aihua Zhang, Jinfeng Yang, Guangli Yan, Tetsuro Sakurai, Xiuhong Wu, Ying Han and Xijun Wang

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4867

    12. Effect of Arctiin on Glomerular Filtration Barrier Damage in STZ-Induced Diabetic Nephropathy Rats

      Song-Tao Ma, Dong-lian Liu, Jing-jing Deng, Rui Niu and Rui-bin Liu

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4884

    13. Hair Growth Activity of Crataegus pinnatifida on C57BL/6 Mouse Model

      Heon-Sub Shin, Jung-Min Lee, Sang-Yong Park, Jung-Eun Yang, Ju-Han Kim and Tae-Hoo Yi

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4870

    14. Glycyrrhetinic Acid Exhibits Strong Inhibitory Effects Towards UDP-Glucuronosyltransferase (UGT) 1A3 and 2B7

      Yin-Peng Huang, Yun-Feng Cao, Zhong-Ze Fang, Yan-Yan Zhang, Cui-Min Hu, Xiao-Yu Sun, Zhen-Wen Yu, Xu Zhu, Mo Hong, Lu Yang and Hong-Zhi Sun

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4875

    15. Anti-Angiogenic Activity of Herba Epimedii on Zebrafish Embryos In Vivo and HUVECs In Vitro

      Xiaobin Yu, Yao Tong, Xiao-Qiang Han, Hin-Fai Kwok, Grace Gar-Lee Yue, Clara Bik-San Lau and Wei Ge

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4881

    16. Inhibition of Prostaglandin D2 Production by Trihydroxy Fatty Acids Isolated from Ulmus davidiana var. japonica

      Hyun Gyu Choi, Yu Mi Park, Yue Lu, Hyeun Wook Chang, MinKyun Na and Seung Ho Lee

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4882

    17. Baicalin and Scutellarin Are Proteasome Inhibitors that Specifically Target Chymotrypsin-like Catalytic Activity

      Yi-Xin Wu, Eiji Sato, Wataru Kimura and Naoyuki Miura

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4878

  49. Reviews

    1. Plant-Based Modulation of Toll-like Receptors: An Emerging Therapeutic Model

      Dev S. Chahal, Raja K. Sivamani, R. Rivkah Isseroff and Mohan R. Dasu

      Article first published online: 12 NOV 2012 | DOI: 10.1002/ptr.4886

  50. Research Articles

    1. Curcumin Serves as a Human Kv1.3 Blocker to Inhibit Effector Memory T Lymphocyte Activities

      Yi-Tian Lian, Xiao-Fang Yang, Zhao-Hui Wang, Yong Yang, Ying Yang, Yan-Wen Shu, Long-Xian Cheng and Kun Liu

      Article first published online: 7 NOV 2012 | DOI: 10.1002/ptr.4863

    2. Effects of Methyl and Isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on Experimental Anxiety and Depression in Mice

      Niko S. Radulović, Ana B. Miltojević, Pavle J. Randjelović, Nikola M. Stojanović and Fabio Boylan

      Article first published online: 7 NOV 2012 | DOI: 10.1002/ptr.4877

    3. Neoplasm Prevention and Immuno-Enhancement Mediated by Daily Consumption of a Proprietary Extract from North American Ginseng by Elderly Mice of a Cancer-Prone Strain

      Punithavathi Durairaj and Sandra C. Miller

      Article first published online: 7 NOV 2012 | DOI: 10.1002/ptr.4880

    4. Hyptis pectinata: Redox Protection and Orofacial Antinociception

      M. S. Paixão, M. S. Melo, M. G. B. Oliveira, M. T. Santana, A. C. B. Lima, N. P. Damascena, A. S. Dias, B. S. Araujo, C. S. Estevam, M. A. Botelho and L. J. Quintans-Júnior

      Article first published online: 7 NOV 2012 | DOI: 10.1002/ptr.4869

    5. Endothelium-Independent Vasorelaxation Effects of Sigesbeckia glabrescens (Makino) Makino on Isolated Rat Thoracic Aorta

      Kyungjin Lee, Jinho Jung, Gabsik Yang, Inhye Ham, Youngmin Bu, Hocheol Kim and Ho-Young Choi

      Article first published online: 30 OCT 2012 | DOI: 10.1002/ptr.4874

    6. Anti-Inflammatory and PPAR Transactivational Properties of Flavonoids from the Roots of Sophora flavescens

      Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Phan Van Kiem, Bui Huu Tai, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Bui Thi Thuy Luyen, Seo Young Yang and Young Ho Kim

      Article first published online: 30 OCT 2012 | DOI: 10.1002/ptr.4871

    7. Antibacterial Effects of Ellagitannins from Acalypha wilkesiana var. macafeana hort.: Surface Morphology Analysis with Environmental Scanning Electron Microcopy and Synergy with Antibiotics

      Wardah Mustafa Din, Khoo Teng Jin, Ramliza Ramli, Tzar Mohd. Nizam Khaithir and Christophe Wiart

      Article first published online: 30 OCT 2012 | DOI: 10.1002/ptr.4876

    8. Effects of Sun Ginseng on Memory Enhancement and Hippocampal Neurogenesis

      Chang Hwan Lee, Jong Min Kim, Dong Hyun Kim, Se Jin Park, Xiaotong Liu, Mudan Cai, Jin Gyu Hong, Jeong Hill Park and Jong Hoon Ryu

      Article first published online: 29 OCT 2012 | DOI: 10.1002/ptr.4873

    9. Bronchodilator Activity of Aerial Parts of Polygonatum verticillatum Augmented by Anti-inflammatory Activity: Attenuation of Ca2+ Channels and Lipoxygenase

      Haroon Khan, Muhammad Saeed, Anwarul Hassan Gilani, Malik Hassan Mehmood, Najeeb-ur Rehman, Naveed Muhammad, Muzaffar Abbas and Ikram-ul Haq

      Article first published online: 29 OCT 2012 | DOI: 10.1002/ptr.4860

    10. L-theanine Administration Results in Neuroprotection and Prevents Glutamate Receptor Agonist-Mediated Injury in the Rat Model of Cerebral Ischemia-Reperfusion

      Mavdzhuda Zukhurova, Maria Prosvirnina, Anastasia Daineko, Anna Simanenkova, Nikolay Petrishchev, Dmitry Sonin, Michael Galagudza, Mark Shamtsyan, Lekh R. Juneja and Timur Vlasov

      Article first published online: 24 OCT 2012 | DOI: 10.1002/ptr.4868

  51. Reviews

    1. Dietary Phosphilipids and Sterols Protective against Peptic Ulceration

      F. I. Tovey, K. D. Bardhan and M. Hobsley

      Article first published online: 24 OCT 2012 | DOI: 10.1002/ptr.4865

  52. Research Articles

    1. Cytotoxic Action of Brazilian Propolis In Vitro on Canine Osteosarcoma Cells

      N. C. Cinegaglia, P. R. O. Bersano, M. C. Búfalo and J. M. Sforcin

      Article first published online: 17 OCT 2012 | DOI: 10.1002/ptr.4861

  53. Short Communications

    1. Yeast Hydrolysate Protects Cartilage via Stimulation of Type II Collagen Synthesis and Suppression of MMP-13 Production

      Hyun-Sun Lee, So Yeon Park, Yooheon Park, Song Hwan Bae and Hyung Joo Suh

      Article first published online: 16 OCT 2012 | DOI: 10.1002/ptr.4857

  54. Research Articles

    1. Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms

      Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong and Lu Yang

      Article first published online: 15 OCT 2012 | DOI: 10.1002/ptr.4855

    2. The Estrogenic Activity of Isoflavones Extracted from Chickpea Cicer arietinum L Sprouts in Vitro

      Ma HaiRong, Wei HuaBo, Chen Zhen, Yang Yi, Wang ZhengHua, Habasi Madina, Cao Xu and Aisa Haji Akber

      Article first published online: 15 OCT 2012 | DOI: 10.1002/ptr.4858

    3. Evaluation of the Antinociceptive Activity of Ocimum gratissimum L. (Lamiaceae) Essential Oil and Its isolated Active Principles in Mice

      L. I. G. Paula-Freire, M. L. Andersen, G. R. Molska, D. O. Köhn and E. L. A. Carlini

      Article first published online: 10 OCT 2012 | DOI: 10.1002/ptr.4845

    4. Aqueous Extract of Yerba Mate Tea Lowers Atherosclerotic Risk Factors in a Rat Hyperlipidemia Model

      Hongli Gao, Zhaochun Liu, Wenju Wan, Xiaolan Qu and Meihua Chen

      Article first published online: 10 OCT 2012 | DOI: 10.1002/ptr.4856

  55. Short Communications

    1. In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin-Resistant Staphylococcus aureus

      Sung-Hwan Eom, Do-Hyung Kim, Sang-Hoon Lee, Na-Young Yoon, Ji Hoe Kim, Tae Hoon Kim, Yong-Hyun Chung, Seon-Bong Kim, Young-Man Kim, Hyun-Woo Kim, Myung-Suk Lee and Young-Mog Kim

      Article first published online: 8 OCT 2012 | DOI: 10.1002/ptr.4851

  56. Research Articles

    1. Inhibitory Effects of Ginsenoside Rb1 on Neuroinflammation Following Systemic Lipopolysaccharide Treatment in Mice

      Joon-Suk Lee, Jeong-Ho Song, Nak-Won Sohn and Jung-Won Shin

      Article first published online: 8 OCT 2012 | DOI: 10.1002/ptr.4852

  57. Reviews

    1. Leonurus cardiaca L. (Motherwort): A Review of its Phytochemistry and Pharmacology

      Katarzyna Wojtyniak, Marcin Szymański and Irena Matławska

      Article first published online: 8 OCT 2012 | DOI: 10.1002/ptr.4850

  58. Full Papers

    1. Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat

      Małgorzata Kujawska, Ewa Ignatowicz, Małgorzata Ewertowska, Teresa Adamska, Jarosław Markowski and Jadwiga Jodynis-Liebert

      Article first published online: 7 OCT 2012 | DOI: 10.1002/ptr.4848

  59. Research Articles

    1. Effects of Aqueous Extracts of Raw Pu-erh Tea and Ripened Pu-Erh Tea on Proliferation and Differentiation of 3T3-L1 Preadipocytes

      Zhen-Hui Cao, Hui Yang, Zhan-Long He, Cheng Luo, Zhi-Qiang Xu, Da-Hai Gu, Jun-Jing Jia, Chang-Rong Ge and Qiu-Ye Lin

      Article first published online: 2 OCT 2012 | DOI: 10.1002/ptr.4831

  60. Full Papers

    1. Anti-inflammatory Effects of the Zingiber officinale roscoe Constituent 12-Dehydrogingerdione in Lipopolysaccharide-stimulated Raw 264.7 Cells

      Young ah Han, Chang woo Song, Woo suk Koh, Gyu hwan Yon, Young sup Kim, Shi yong Ryu, Hoon jeong Kwon and Kyu hong Lee

      Article first published online: 2 OCT 2012 | DOI: 10.1002/ptr.4847

  61. Research Articles

    1. Chemical composition and biological activities of polar extracts and essential oil of rose-scented geranium, Pelargonium graveolens

      Maher Boukhris, Monique S. J. Simmonds, Sami Sayadi and Mohamed Bouaziz

      Article first published online: 2 OCT 2012 | DOI: 10.1002/ptr.4853

    2. Effect of Diphlorethohydroxycarmalol Isolated From Ishige okamurae on Apoptosis in 3 t3-L1 Preadipocytes

      Mi Hwa Park, You-Jin Jeon, Hak-Ju Kim and Ji Sook Han

      Article first published online: 25 SEP 2012 | DOI: 10.1002/ptr.4797

    3. Gingerol-Induced Hypoxia-Inducible Factor 1 Alpha Inhibits Human Prion Peptide-Mediated Neurotoxicity

      Jae-Kyo Jeong, Myung-Hee Moon, Yang-Gyu Park, Ju-Hee Lee, You-Jin Lee, Jae-Won Seol and Sang-Youel Park

      Article first published online: 25 SEP 2012 | DOI: 10.1002/ptr.4842

    4. Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

      Zheng Li, Jing-Jie Li, Li-Juan Gu, Dong-Liang Zhang, Yun-Bo Wang and Chang-Keun Sung

      Article first published online: 25 SEP 2012 | DOI: 10.1002/ptr.4828

    5. Species Differences in the Antidiarrheal and Antispasmodic Activities of Lepidium sativum and Insight into Underlying Mechanisms

      Anwarul-Hassan Gilani, Najeeb-ur Rehman, Malik Hassan Mehmood and Khalid M. AlKharfy

      Article first published online: 25 SEP 2012 | DOI: 10.1002/ptr.4819

  62. Full Papers

    1. Maohuoside A Acts in a BMP-dependent Manner during Osteogenesis

      Ming Cai, Guodong Li, Kun Tao, Yunji Yang, Lieming Lou, Zhengdong Cai and Yongchun Yu

      Article first published online: 25 SEP 2012 | DOI: 10.1002/ptr.4840

  63. Research Articles

    1. Acute and Sub-Acute Oral Toxicity Assessment of the Hydroalcoholic Extract of Withania somnifera Roots in Wistar Rats

      P. C. Prabu, S. Panchapakesan and C. David Raj

      Article first published online: 21 SEP 2012 | DOI: 10.1002/ptr.4854

  64. Short Communications

    1. Effect of Wuzhi Tablet (Schisandra sphenanthera extract) on the Pharmacokinetics of Cyclosporin A in Rats

      Xin-ping Xue, Xiao-ling Qin, Chenshu Xu, Guo-ping Zhong, Ying Wang, Min Huang and Hui-chang Bi

      Article first published online: 21 SEP 2012 | DOI: 10.1002/ptr.4849

  65. Research Articles

    1. Anti-Microbial Activity and Composition of Manuka and Portobello Honey

      Monika Schneider, Shirley Coyle, Mary Warnock, Iain Gow and Lorna Fyfe

      Article first published online: 18 SEP 2012 | DOI: 10.1002/ptr.4844

  66. Short Communications

    1. The Edible red Alga, Gracilaria verrucosa, Inhibits Lipid Accumulation and ROS Production, but Improves Glucose Uptake in 3T3-L1 Cells

      Mi-Seon Woo, Hyeon-Son Choi, Ok-Hwan Lee and Boo-Yong Lee

      Article first published online: 18 SEP 2012 | DOI: 10.1002/ptr.4813

  67. Research Articles

    1. An Investigation of the Antidepressant Action of Xiaoyaosan in Rats Using Ultra performance Liquid Chromatography–Mass Spectrometry Combined with Metabonomics

      Xiao-Xia Gao, Jie Cui, Xing-Yu Zheng, Zhen-Yu Li, Young-Hae Choi, Yu-Zhi Zhou, Jun-Sheng Tian, Jie Xing, Xiao-Jie Tan, Guan-Hua Du and Xue-Mei Qin

      Article first published online: 13 SEP 2012 | DOI: 10.1002/ptr.4805

    2. The Novel p53-Dependent Metastatic and Apoptotic Pathway Induced by Vitexin in Human Oral Cancer OC2 Cells

      Shih-Huang Yang, Pao-Hsin Liao, Ya-Fang Pan, Shiow-Ling Chen, Shih-Shen Chou and Ming-Yung Chou

      Article first published online: 13 SEP 2012 | DOI: 10.1002/ptr.4841

  68. Full Papers

    1. Silibinin Regulates Matrix Metalloproteinase 3 (Stromelysine1) Gene Expression, Hexoseamines and Collagen Production During Rat Skin Wound Healing

      Mohammad Reza Tabandeh, Ahamd Oryan, Adel Mohhammad-Alipour and Abotorab Tabatabaei-Naieni

      Article first published online: 13 SEP 2012 | DOI: 10.1002/ptr.4839

  69. Reviews

    1. A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts

      Sidney J. Stohs and Sidhartha D. Ray

      Article first published online: 13 SEP 2012 | DOI: 10.1002/ptr.4846

  70. Research Articles

    1. In Vitro Cytotoxicity Assessment of Ulvan, a Polysaccharide Extracted from Green Algae

      Anabela Alves, Rui A. Sousa and Rui L. Reis

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4843

    2. Studies on Prokinetic, Laxative and Spasmodic Activities of Phyllanthus emblica in Experimental Animals

      Malik Hassan Mehmood, Abdul Rehman, Najeeb-ur-Rehman and Anwarul-Hassan Gilani

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4821

    3. Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1

      JingYuan Wan, Xia Gong, Rong Jiang, Zhuo Zhang and Li Zhang

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4838

  71. Short Communications

    1. Intrathecal [6]-Gingerol Administration Alleviates Peripherally induced Neuropathic Pain in Male Sprague–Dawley Rats

      Marie-Lou Gauthier, Francis Beaudry and Pascal Vachon

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4837

  72. Reviews

    1. Panax ginseng in Randomised Controlled Trials: A Systematic Review

      Johannah L. Shergis, Anthony L. Zhang, Wenyu Zhou and Charlie C. Xue

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4832

  73. Research Articles

    1. Antiulcer Effect of Bark Extract of Tabebuia avellanedae: Activation of Cell Proliferation in Gastric Mucosa During the Healing Process

      Isabela Tiemy Pereira, Lígia Moura Burci, Luisa Mota da Silva, Cristiane Hatsuko Baggio, Melina Heller, Gustavo Amadeu Micke, Moacir Geraldo Pizzolatti, Maria Consuelo Andrade Marques and Maria Fernanda Werner

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4835

    2. In Vitro Activity of Xanthorrhizol Isolated from the Rhizome of Javanese Turmeric (Curcuma xanthorrhiza Roxb.) Against Candida albicans Biofilms

      Yaya Rukayadi and Jae-Kwan Hwang

      Article first published online: 12 SEP 2012 | DOI: 10.1002/ptr.4834

    3. Comparison of the Effects of Pelargonic Acid Vanillylamide and Capsaicin on Human Vanilloid Receptors

      Thomas Weiser, Basil Roufogalis and Sigrun Chrubasik

      Article first published online: 7 SEP 2012 | DOI: 10.1002/ptr.4817

    4. Erucin and Benzyl Isothiocyanate Suppress Growth of Late Stage Primary Human Ovarian Carcinoma Cells and Telomerase Activity In Vitro

      Evelyn Lamy, Dewi Oey, Florian Eißmann, Corinna Herz, Karsten Münstedt, Hans-Rudolf Tinneberg and Volker Mersch-Sundermann

      Article first published online: 5 SEP 2012 | DOI: 10.1002/ptr.4798

    5. Effect of Crocin on the Insulin Resistance and Lipid Profile of Streptozotocin-Induced Diabetic Rats

      Saeed Shirali, S. Zahra Bathaie and Manouchehr Nakhjavani

      Article first published online: 5 SEP 2012 | DOI: 10.1002/ptr.4836

    6. Schizonepeta tenuifolia Inhibits the Development of Atopic Dermatitis in Mice

      You Yeon Choi, Mi Hye Kim, Jong-Hyun Kim, Hyuk-Sang Jung, Youngjoo Sohn, Young Jin Choi, Man Ki Hwang, Sung-Hoon Kim, Jinju Kim and Woong Mo Yang

      Article first published online: 4 SEP 2012 | DOI: 10.1002/ptr.4833

    7. Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride

      Jann-Inn Tzeng, Mei-Fen Chen, Hsien-Hui Chung and Juei-Tang Cheng

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4829

    8. Inhaled Cissampelos sympodialis Down-Regulates Airway Allergic Reaction by Reducing Lung CD3+T Cells

      Giciane C. Vieira, Josenilson F. De Lima, Regina C. B. Q. De Figueiredo, Sandra R. Mascarenhas, Claudio R. Bezerra-Santos and Marcia R. Piuvezam

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4791

    9. Assessment of Long-Term Storage on Antimicrobial and Cyclooxygenase-Inhibitory Properties of South African Medicinal Plants

      Stephen O. Amoo, Adeyemi O. Aremu, Mack Moyo and Johannes Van Staden

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4830

    10. Sanguisorbae Radix Protects Against 6-Hydroxydopamine-induced Neurotoxicity by Regulating NADPH Oxidase and NF-E2-related Factor-2/Heme Oxygenase-1 Expressions

      Hyein Oh, Jinyoung Hur, Gunhyuk Park, Hyo Geun Kim, Young Ock Kim and Myung Sook Oh

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4802

    11. Anti-Inflammatory, Antinociceptive and Cytotoxic Effects of the Methanol Extract of Cecropia Pachystachya Trécul

      Danielle Maria de Oliveira Aragão, Isabel Vieira de Assis Lima, Josiane Mello da Silva, Paula Maria Quaglio Bellozi, Juliana de Carvalho da Costa, Gabriele Mendes Matos Cardoso, Elaine Maria de Souza-Fagundes and Elita Scio

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4811

    12. Effect of Plant Polyphenols on Ischemia-Reperfusion Injury of the Isolated rat Heart and Vessels

      Z. Brosková, K. Drábiková, R. Sotníková, S. Fialová and V. Knezl

      Article first published online: 30 AUG 2012 | DOI: 10.1002/ptr.4825

    13. Antifungal Compounds from the Rhizome and Roots of Ferula hermonis

      Abdel-Hadi Al-Ja'fari, Roser Vila, Blanca Freixa, Joan Costa and Salvador Cañigueral

      Article first published online: 23 AUG 2012 | DOI: 10.1002/ptr.4806

    14. Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters

      Young Sook Yun, Sachie Noda, Genta Shigemori, Ryunosuke Kuriyama, Shigeru Takahashi, Mariko Umemura, Yuji Takahashi and Hideshi Inoue

      Article first published online: 23 AUG 2012 | DOI: 10.1002/ptr.4794

    15. The Apoptotic Effects of Escin in The H-Ras Transformed 5RP7 Cell Line

      G. Güney, H. M. Kutlu and A. İşcan

      Article first published online: 21 AUG 2012 | DOI: 10.1002/ptr.4804

    16. A Novel Extract of Gymnema sylvestre Improves Glucose Tolerance In Vivo and Stimulates Insulin Secretion and Synthesis In Vitro

      A. Al-Romaiyan, A. J. King, S. J. Persaud and P. M. Jones

      Article first published online: 21 AUG 2012 | DOI: 10.1002/ptr.4815

    17. Effects of Oligomeric Grape Seed Proanthocyanidins on Heart, Aorta, Kidney in DOCA-Salt Mice: Role of Oxidative Stress

      Xing-hui Wang, Ling-ling Huang, Ting-ting Yu, Jin-hang Zhu, Bing Shen, Ye Zhang, Hong-zhi Wang and Shan Gao

      Article first published online: 18 AUG 2012 | DOI: 10.1002/ptr.4793

    18. Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells

      Jing Tong, Shutao Yin, Yinhui Dong, Xiao Guo, Lihong Fan, Min Ye and Hongbo Hu

      Article first published online: 18 AUG 2012 | DOI: 10.1002/ptr.4808

    19. Cinnamophilin Isolated from Cinnamomum philippinense Protects against Collagen Degradation in Human Chondrocytes

      Yung-Chang Lu, George Hsiao, Kuan-Hung Lin, Ming-Shium Hsieh, Thanasekaran Jayakumar, Tian-Shung Wu and Joen-Rong Sheu

      Article first published online: 18 AUG 2012 | DOI: 10.1002/ptr.4812

    20. Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms

      Şahin Nuri Yaşar, Özgür Devrim Can, Nilgün Öztürk, Gianni Sagratini, Massimo Ricciutelli, Sauro Vittori and Filippo Maggi

      Article first published online: 18 AUG 2012 | DOI: 10.1002/ptr.4801

  74. Short Communications

    1. Reducing Effect of a Combination of Phaseolus vulgaris and Cynara scolymus Extracts on Operant Self-Administration of a Chocolate-Flavoured Beverage in Rats

      Alessandro Zaru, Paola Maccioni, Antonella Riva, Paolo Morazzoni, Ezio Bombardelli, Gian Luigi Gessa, Mauro A. M. Carai and Giancarlo Colombo

      Article first published online: 17 AUG 2012 | DOI: 10.1002/ptr.4814

  75. Research Articles

    1. Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2-Dimethylhydrazine-Induced Colon Cancer

      Selvaraj Aranganathan and Namasivayam Nalini

      Article first published online: 17 AUG 2012 | DOI: 10.1002/ptr.4826

    2. Evaluation of Bioactive Potential of an Aloe vera Sterol Extract

      Raksha Bawankar, V. C. Deepti, Pooja Singh, Rathinasamy Subashkumar, Govindasamy Vivekanandhan and Subramanian Babu

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4827

    3. Effects of Penta-O-galloyl-β-D-glucose on Human Neutrophil Function: significant Down-Regulation of L-selectin Expression

      Anna K. Kiss, Agnieszka Filipek, Barbara Żyżyńska-Granica and Marek Naruszewicz

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4822

    4. Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity

      Ivana Z. Matić, Zorica Juranić, Katarina Šavikin, Gordana Zdunić, Neva Nađvinski and Dejan Gođevac

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4807

    5. In vitro Anti-diabetic Activity and Chemical Characterization of an Apolar Fraction of Morus alba Leaf Water Extract

      Attila Hunyadi, Katalin Veres, Balazs Danko, Zoltan Kele, Edit Weber, Anasztazia Hetenyi, Istvan Zupko and Tusty-Jiuan Hsieh

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4803

    6. The Anti-Angiogenic Activities of Glycyrrhizic Acid in Tumor Progression

      Kil-Jung Kim, Jae-Sun Choi, Kyu-Won Kim and Joo-Won Jeong

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4800

    7. Phytochemicals Isolated from Leaves of Chromolaena odorata: Impact on Viability and Clonogenicity of Cancer Cell Lines

      Prevost Bi-Koffi Kouamé, Camille Jacques, Gustave Bedi, Virginie Silvestre, Denis Loquet, Sophie Barillé-Nion, Richard J Robins and Illa Tea

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4787

    8. Antimycobacterials from Lovage Root (Ligusticum officinale Koch)

      Juan David Guzman, Dimitrios Evangelopoulos, Antima Gupta, Jose M. Prieto, Simon Gibbons and Sanjib Bhakta

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4823

    9. Study of Heavy Metal Poisoning in Frequent Users of Chinese Medicines in Hong Kong and Macau

      S.H. Chui, Y.H. Wong, H.I. Chio, M.Y. Fong, Y.M. Chiu, Y.T. Szeto, W.T. Vong and C.W.K Lam

      Article first published online: 16 AUG 2012 | DOI: 10.1002/ptr.4816

    10. Zizyphus jujuba and its Active Component Jujuboside B Inhibit Platelet Aggregation

      Eun Ji Seo, So Young Lee, Sam Sik Kang and Yi-Sook Jung

      Article first published online: 15 AUG 2012 | DOI: 10.1002/ptr.4809

    11. Bioactivity-guided Isolation of Antiosteoporotic Compounds from Ligustrum lucidum

      Qianfeng Chen, Lijuan Yang, Guolin Zhang and Fei Wang

      Article first published online: 15 AUG 2012 | DOI: 10.1002/ptr.4820

    12. The Immunosuppressive Activity of Pseudolaric Acid B on T lymphocytes in vitro

      Na Wei, Tan Li, Hong Chen, Xin Mei, Bo Cao and Yu-yang Zhang

      Article first published online: 15 AUG 2012 | DOI: 10.1002/ptr.4824

    13. Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease

      Naoki Uchida, Kotaro Takasaki, Yuri Sakata, Ai Nogami, Hiroshi Oishi, Takuya Watanabe, Taro Shindo, Nobuaki Egashira, Kaori Kubota, Shutaro Katsurabayashi, Kenichi Mishima, Michihiro Fujiwara, Ryoji Nishimura and Katsunori Iwasaki

      Article first published online: 11 AUG 2012 | DOI: 10.1002/ptr.4818

  76. Reviews

    1. A New Perspective on the Quercetin Paradox in Male Reproductive Dysfunction

      Pavitra Ranawat, Chander Mohan Pathak and Krishan Lal Khanduja

      Article first published online: 8 AUG 2012 | DOI: 10.1002/ptr.4799

    2. The Bioactive and Therapeutic Potential of Hemidesmus indicus R. Br. (Indian Sarsaparilla) Root

      Sarita Das and Satpal Singh Bisht

      Article first published online: 8 AUG 2012 | DOI: 10.1002/ptr.4788

  77. Research Articles

    1. You have full text access to this OnlineOpen article
      Combination of Comfrey Root Extract Plus Methyl Nicotinate in Patients with Conditions of Acute Upper or Low Back Pain: A Multicentre Randomised Controlled Trial

      Helmut Pabst, Axel Schaefer, Christiane Staiger, Marc Junker-Samek and Hans-Georg Predel

      Article first published online: 8 AUG 2012 | DOI: 10.1002/ptr.4790

    2. High throughput Screening to Identify Natural Human Monoamine Oxidase B Inhibitors

      E Mazzio, S Deiab, K Park and KFA Soliman

      Article first published online: 8 AUG 2012 | DOI: 10.1002/ptr.4795

  78. Errata

    1. Neuroprotective Effect of Rhizoma Atractylodis Macrocephalae Against Excitotoxicity-induced Apoptosis in Cultured Cerebral Cortical Neurons

      Qun Gao, Zhi-Hong Ji, Yang Yang, Rui Cheng and Xin-Yu Yu

      Article first published online: 8 AUG 2012 | DOI: 10.1002/ptr.4789

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