Phytotherapy Research

Cover image for Vol. 30 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Elizabeth M. Williamson, Angelo A Izzo, Sung Hoon-Kim and Rajan Radhakrishnan

Impact Factor: 2.694

ISI Journal Citation Reports © Ranking: 2015: 28/59 (Chemistry Medicinal); 94/253 (Pharmacology & Pharmacy)

Online ISSN: 1099-1573


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  1. Research Articles

    1. Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis

      Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu and Ganzhen Deng

      Version of Record online: 23 JUN 2016 | DOI: 10.1002/ptr.5666

    2. Methanol Extract of Bitter Melon Alleviates UVB-Induced MMPs Expression via MAP Kinase and AP-1 Signaling in Human Dermal Fibroblasts in vitro

      Hyun Ji Lee, Eunson Hwang, Bom Park, Mengyang Zhang, Zheng-wang Sun, Do-Gyeong Lee, Sang-Yong Park and Tae Hoo Yi

      Version of Record online: 22 JUN 2016 | DOI: 10.1002/ptr.5656

  2. Reviews

    1. Therapeutic Potential of Essential Oils Focusing on Diterpenes

      Md. Torequl Islam, Ana Maria Oliveira Ferreira da Mata, Raí Pablo Sousa de Aguiar, Marcia Fernanda Correia Jardim Paz, Marcus Vinícius Oliveira Barros de Alencar, Paulo Michel Pinheiro Ferreira and Ana Amélia de Carvalho Melo-Cavalcante

      Version of Record online: 16 JUN 2016 | DOI: 10.1002/ptr.5652

      Thumbnail image of graphical abstract

      Dimethayllyl-pyrophosphate (DAPP) is the ultimate product of the pyryvate-glyceraldehyde-3-P and 2-acetyl-Co-A pathways, as it can reversibly turn to isopentenyl-pyrophosphate (IPP) moiety. These two then undergoing a head-tail condensation in the presence of geranyl-pyrophosphate (GPP) synthase form GPP. Upon a step-wise addition of further IPPs, they ultimately form diterpenes.

  3. Research Articles

    1. Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts

      Adnan Amin, Emmy Tuenter, Vassiliki Exarchou, Atul Upadhyay, Paul Cos, Louis Maes, Sandra Apers and Luc Pieters

      Version of Record online: 10 JUN 2016 | DOI: 10.1002/ptr.5663

    2. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial

      Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi and Sin Gon Kim

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5664

    3. Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

      Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji and Tahereh Farkhondeh

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5638

  4. Reviews

    1. A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch

      Shefton Parker, Brian May, Claire Zhang, Anthony Lin Zhang, Chuanjian Lu and Charlie Changli Xue

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5653

  5. Research Articles

    1. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

      Sepideh Rahmani, Sedigheh Asgary, Gholamreza Askari, Mahtab Keshvari, Mahdi Hatamipour, Awat Feizi and Amirhossein Sahebkar

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/ptr.5659

    2. Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients—A Pilot Study

      Andrea Čabarkapa, Lada Živković, Sunčica Borozan, Mirjana Zlatković-Švenda, Dragana Dekanski, Ivan Jančić, Marija Radak-Perović, Vladan Bajić and Biljana Spremo-Potparević

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/ptr.5662

  6. Reviews

  7. Research Articles

    1. An Hydroalcoholic Chamomile Extract Modulates Inflammatory and Immune Response in HT29 Cells and Isolated Rat Colon

      Luigi Menghini, Claudio Ferrante, Lidia Leporini, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Giorgio Pintore, Michele Vacca, Giustino Orlando and Luigi Brunetti

      Version of Record online: 30 MAY 2016 | DOI: 10.1002/ptr.5655

    2. Attenuation of Adhesion, Biofilm Formation and Quorum Sensing of Campylobacter jejuni by Euodia ruticarpa

      Katja Bezek, Marija Kurinčič, Elvira Knauder, Anja Klančnik, Peter Raspor, Franz Bucar and Sonja Smole Možina

      Version of Record online: 27 MAY 2016 | DOI: 10.1002/ptr.5658

    3. The Prokinetic, Laxative, and Antidiarrheal Effects of Morus nigra: Possible Muscarinic, Ca2+ Channel Blocking, and Antimuscarinic Mechanisms

      Anam Akhlaq, Malik Hassan Mehmood, Abdul Rehman, Zohaib Ashraf, Sadia Syed, Samira Ahmed Bawany, Anwarul-Hassan Gilani, Maimoona Ilyas and Bina Shaheen Siddiqui

      Version of Record online: 27 MAY 2016 | DOI: 10.1002/ptr.5641

  8. Reviews

    1. Chemistry, Pharmacology and Health Benefits of Anthocyanins

      Antonella Smeriglio, Davide Barreca, Ersilia Bellocco and Domenico Trombetta

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/ptr.5642

  9. Research Articles

    1. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia

      Shima Hirako, Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Tomoko Nakano, Kenji Imai, Hua Li, Shinya Toyokuni and Fumitaka Kikkawa

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/ptr.5645

  10. Reviews

    1. Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

      Igor A. Schepetkin, Andrew G. Ramstead, Liliya N. Kirpotina, Jovanka M. Voyich, Mark A. Jutila and Mark T. Quinn

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/ptr.5648

  11. Research Articles

  12. Reviews

    1. You have free access to this content
    2. The Chemistry and Biological Activities of Mimosine: A Review

      Binh Cao Quan Nguyen and Shinkichi Tawata

      Version of Record online: 23 MAY 2016 | DOI: 10.1002/ptr.5636

      Thumbnail image of graphical abstract
      • Mimosine has been evolved as a multi-functional compound.
      • Mimosine has been found as a leading compound for development of protein-activated kinase 1 inhibitors.
      • The new evidences to explain why mimosine is implicated in regenerative dentistry, periodontal regeneration, oral surgery, and phytoremediation.
      • The review is to bridge the gaps between the chemistry and recognized biological activities of mimosine.
  13. Research Articles

    1. Anti-Proliferation Effects of Garlic (Allium sativum L.) on the Progression of Benign Prostatic Hyperplasia

      Kyung-Sook Chung, Su-Jin Shin, Na Young Lee, Se-Yun Cheon, Wansu Park, Seung-Ho Sun and Hyo-Jin An

      Version of Record online: 18 MAY 2016 | DOI: 10.1002/ptr.5637

  14. Reviews

    1. Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

      Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, Huyiligeqi and Jian Ni

      Version of Record online: 18 MAY 2016 | DOI: 10.1002/ptr.5631

    2. Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials

      Ji Young Lee, Seung Ah Jun, Sung Shin Hong, Yo Chan Ahn, Dong Soo Lee and Chang Gue Son

      Version of Record online: 16 MAY 2016 | DOI: 10.1002/ptr.5647

  15. Research Articles

    1. The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats

      Stanislava Jankyova, Dominika Rubintova, Lenka Janosikova, Peter Panek, Tatiana Foltanova and Eva Kralova

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/ptr.5639

    2. Acetonic Extract from the Feijoa sellowiana Berg. Fruit Exerts Antioxidant Properties and Modulates Disaccharidases Activities in Human Intestinal Epithelial Cells

      Fabio Turco, Ilaria Palumbo, Paolo Andreozzi, Giovanni Sarnelli, Francesca De Ruberto, Giuseppe Esposito, Adriana Basile and Rosario Cuomo

      Version of Record online: 10 MAY 2016 | DOI: 10.1002/ptr.5629

  16. Reviews

  17. Research Articles

    1. Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

      Ayodele Jacob Akinyemi, Gustavo Roberto Thomé, Vera Maria Morsch, Nathieli B. Bottari, Jucimara Baldissarelli, Lizielle Souza de Oliveira, Jeferson Ferraz Goularte, Adriane Belló-Klein, Ganiyu Oboh and Maria Rosa Chitolina Schetinger

      Version of Record online: 6 MAY 2016 | DOI: 10.1002/ptr.5621

    2. Polyphenols from Artemisia annua L Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231

      Young Shin Ko, Won Sup Lee, Radha Panchanathan, Young Nak Joo, Yung Hyun Choi, Gon Sup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin and Hye Jung Kim

      Version of Record online: 6 MAY 2016 | DOI: 10.1002/ptr.5626

  18. Reviews

    1. Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials

      Tao Song, Xiaoli Hou, Xiaohui Yu, Zhen Wang, Ruiren Wang, Yanling Li, Dan Hu, Xiaohong Wang, Zhengzheng Xiao, Yong Sui, Chunhong Zhu and Jing Wang

      Version of Record online: 4 MAY 2016 | DOI: 10.1002/ptr.5628

  19. Research Articles

    1. Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin

      Hui Zhang, Zhenying Zhao, Tao Wang, Yijia Wang, Xiao Cui, Huijuan Zhang and Zhong-Ze Fang

      Version of Record online: 4 MAY 2016 | DOI: 10.1002/ptr.5627

    2. Bioavailability of Bioactive Molecules from Olive Leaf Extracts and its Functional Value

      Daniel Martín-Vertedor, María Garrido, José Antonio Pariente, Javier Espino and Jonathan Delgado-Adámez

      Version of Record online: 3 MAY 2016 | DOI: 10.1002/ptr.5625

  20. Reviews

  21. Research Articles

    1. Polyphenolic Compounds and Antioxidant Activity of Cold-Pressed Seed Oil from Finola Cultivar of Cannabis sativa L.

      Antonella Smeriglio, Enza M. Galati, Maria T. Monforte, Francesco Lanuzza, Valeria D'Angelo and Clara Circosta

      Version of Record online: 14 APR 2016 | DOI: 10.1002/ptr.5623

  22. Reviews

    1. Scope of Hydrolysable Tannins as Possible Antimicrobial Agent

      Sanmuga Priya Ekambaram, Senthamil Selvan Perumal and Ajay Balakrishnan

      Version of Record online: 7 APR 2016 | DOI: 10.1002/ptr.5616

    2. Medicinal Plants with Antiplatelet Activity

      Mohammed El Haouari and Juan A. Rosado

      Version of Record online: 6 APR 2016 | DOI: 10.1002/ptr.5619

  23. Research Articles

    1. Depressant Effects of Salvia divinorum Involve Disruption of Physiological Sleep

      María Eva González-Trujano, Fernando Brindis, Edith López-Ruiz, Ignacio Ramírez-Salado, Adrián Martínez and Francisco Pellicer

      Version of Record online: 1 APR 2016 | DOI: 10.1002/ptr.5617

    2. Polyphenol-Rich Fraction from Larrea divaricata and its Main Flavonoid Quercetin-3-Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress

      Renzo Martino, María Laura Barreiro Arcos, Rosario Alonso, Valeria Sülsen, Graciela Cremaschi and Claudia Anesini

      Version of Record online: 1 APR 2016 | DOI: 10.1002/ptr.5615

    3. Erectogenic and Aphrodisiac Property of Moringa oleifera: Involvement of Soluble Epoxide Hydrolase Enzyme

      Sumanta Kumar Goswami, Mohammed Naseeruddin Inamdar, Shekhar M. Dethe, Giligar M. Gururaj, Rohitash Jamwal, Anirban Bhaskar, Deepak Mundkinajeddu and Amit Agarwal

      Version of Record online: 28 MAR 2016 | DOI: 10.1002/ptr.5614


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