Phytotherapy Research

Cover image for Vol. 30 Issue 10

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Elizabeth M. Williamson, Angelo A Izzo, Sung Hoon-Kim and Rajan Radhakrishnan

Impact Factor: 2.694

ISI Journal Citation Reports © Ranking: 2015: 28/59 (Chemistry Medicinal); 94/253 (Pharmacology & Pharmacy)

Online ISSN: 1099-1573


  1. 1 - 52
  1. Research Articles

    1. Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model

      Bonglee Kim, Moon-Jea Woo, Chul-Soo Park, Sang-Hun Lee, Jin-Soo Kim, Boim Kim, Seho An and Sung-Hoon Kim

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/ptr.5741

  2. Reviews

    1. Role of Medicinal Plants for Liver-Qi Regulation Adjuvant Therapy in Post-stroke Depression: A Systematic Review of Literature

      Ling-Feng Zeng, Ye Cao, Lu Wang, Yun-Kai Dai, Ling Hu, Qi Wang, Li-Ting Zhu, Wen-Hu Bao, Yuan-Ping Zou, Yun-Bo Chen, Wei-Hua Xu, Wei-Xiong Liang and Ning-Sheng Wang

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/ptr.5740

  3. Research Articles

    1. Effects of Ginsenoside Rg1 on Learning and Memory in a Reward-directed Instrumental Conditioning Task in Chronic Restraint Stressed Rats

      Wang Kezhu, Xu Pan, Lu Cong, Dong Liming, Zhang Beiyue, Lu Jingwei, Yang Yanyan and Liu Xinmin

      Version of Record online: 20 OCT 2016 | DOI: 10.1002/ptr.5733

  4. Book Reviews

  5. Reviews

    1. Clinical Pharmacology of Citrus bergamia: A Systematic Review

      Carmen Mannucci, Michele Navarra, Fabrizio Calapai, Raffaele Squeri, Sebastiano Gangemi and Gioacchino Calapai

      Version of Record online: 17 OCT 2016 | DOI: 10.1002/ptr.5734

  6. Research Articles

    1. Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds

      Giovanna Simonetti, Felicia Diodata D'Auria, Nadia Mulinacci, Marzia Innocenti, Donato Antonacci, Letizia Angiolella, Anna Rita Santamaria, Alessio Valletta, Livia Donati and Gabriella Pasqua

      Version of Record online: 13 OCT 2016 | DOI: 10.1002/ptr.5739

    2. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer

      Takumu Hasebe, Jun Matsukawa, Daina Ringus, Jun Miyoshi, John Hart, Atsushi Kaneko, Masahiro Yamamoto, Toru Kono, Mikihiro Fujiya, Yutaka Kohgo, Chong-Zi Wang, Chun-Su Yuan, Marc Bissonnette, Mark W. Musch and Eugene B. Chang

      Version of Record online: 12 OCT 2016 | DOI: 10.1002/ptr.5735

    3. Novel Compounds with new Anti-Ulcergenic Activity from Convolvulus pilosellifolius Using Bio-Guided Fractionation.

      Amani S. Awaad, Asmaa Al-Refaie, Reham El-Meligy, Mohamed Zain, Hesham Soliman, Mohamed S. Marzoke and Nabil El-Sayed

      Version of Record online: 12 OCT 2016 | DOI: 10.1002/ptr.5730

  7. Letters to the Editor

  8. Research Articles

    1. Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats

      Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi and Kakasaheb Mahadik

      Version of Record online: 7 OCT 2016 | DOI: 10.1002/ptr.5731

    2. Bilberry: Chemical Profiling, in Vitro and in Vivo Antioxidant Activity and Nephroprotective Effect against Gentamicin Toxicity in Rats

      Milica Veljković, Dragana R. Pavlović, Nenad Stojiljković, Sonja Ilić, Ivan Jovanović, Nataša Poklar Ulrih, Violeta Rakić, Ljubinka Veličković and Dušan Sokolović

      Version of Record online: 6 OCT 2016 | DOI: 10.1002/ptr.5738

  9. Reviews

    1. Plants as Antileishmanial Agents: Current Scenario

      Nazif Ullah, Akhtar Nadhman, Sumaira Siddiq, Shaila Mehwish, Arshad Islam, Laila Jafri and Muhammad Hamayun

      Version of Record online: 5 OCT 2016 | DOI: 10.1002/ptr.5710

      Thumbnail image of graphical abstract

      The current resistance and the toxic effects of the available drugs have brought the trend to assess the antileishmanial effect of various plant extracts and their purified compound/s. Natural products are potential source of new and selective agents that can significantly contribute to primary healthcare and probably are promising substitutes of available drugs for the treatment of protozoan diseases like leishmaniasis. However, to develop such compounds as next drug against leishmaniasis, it is very important to test natural agents both in in-vivo and in host macrophages.

  10. Research Articles

    1. Antiinflammatory Effects of Functionally Active Compounds Isolated from Aged Black Garlic

      Dong-gyu Kim, Min Jung Kang, Seong Su Hong, Yun-Hyeok Choi and Jung Hye Shin

      Version of Record online: 30 SEP 2016 | DOI: 10.1002/ptr.5726

    2. Inhibitory Effects of Multiple-Dose Treatment with Baicalein on the Pharmacokinetics of Ciprofloxacin in Rats

      Youn-Hwan Hwang, Hye Jin Yang, Dong-Gun Kim and Jin Yeul Ma

      Version of Record online: 26 SEP 2016 | DOI: 10.1002/ptr.5728

  11. Reviews

    1. A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

      Bhesh Raj Sharma, Lekh Nath S. Gautam, Deepak Adhikari and Rajendra Karki

      Version of Record online: 26 SEP 2016 | DOI: 10.1002/ptr.5732

  12. Research Articles

    1. THC (Δ9-Tetrahydrocannabinol) Exerts Neuroprotective Effect in Glutamate-affected Murine Primary Mesencephalic Cultures Through Restoring Mitochondrial Membrane Potential and Anti-apoptosis Involving CB1 Receptor-dependent Mechanism

      Chi Huu Nguyen, Christopher Krewenka, Khaled Radad, Barbara Kranner, Alexandra Huber, Johanna Catharina Duvigneau, Ingrid Miller and Rudolf Moldzio

      Version of Record online: 22 SEP 2016 | DOI: 10.1002/ptr.5712

    2. Antimycobacterial Activity and Low Cytotoxicity of Leaf Extracts of Some African Anacardiaceae Tree Species

      Prudence N. Kabongo-Kayoka, Jacobus N. Eloff, Chikwelu L. Obi and Lyndy J. McGaw

      Version of Record online: 13 SEP 2016 | DOI: 10.1002/ptr.5706

    3. Characterization of Phloroglucinol-enriched Fractions of Brazilian Hypericum Species and Evaluation of Their Effect on Human Keratinocytes Proliferation

      Henrique Bridi, Aline Beckenkamp, Gari Vidal Ccana-Ccapatinta, Sérgio Augusto de Loreto Bordignon, Andréia Buffon and Gilsane Lino von Poser

      Version of Record online: 13 SEP 2016 | DOI: 10.1002/ptr.5727

    4. Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression

      Hyeong Sim Choi, Sung-Gook Cho, Min Kyoung Kim, Min Soo Kim, Seung Hee Moon, Il Hwan Kim and Seong-Gyu Ko

      Version of Record online: 8 SEP 2016 | DOI: 10.1002/ptr.5708

    5. Perioperative Bromelain Therapy after Wisdom Teeth Extraction – A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study

      Kai-Hendrik Bormann, Kristina Weber, Heike Kloppenburg, Armin Koch, Peter Meiser and Nils-Claudius Gellrich

      Version of Record online: 6 SEP 2016 | DOI: 10.1002/ptr.5707

    6. Germacrone Inhibits Estrogen Receptor α-Mediated Transcription in MCF-7 Breast Cancer Cells

      Mi-Sun Lim, Se-Young Choung and Kwang Won Jeong

      Version of Record online: 30 AUG 2016 | DOI: 10.1002/ptr.5711

    7. You have full text access to this OnlineOpen article
      Cinnamaldehyde, Carvacrol and Organic Acids Affect Gene Expression of Selected Oxidative Stress and Inflammation Markers in IPEC-J2 Cells Exposed to Salmonella typhimurium

      Sara A. Burt, Simone J.M. Adolfse, Dina S.A. Ahad, Monique H.G. Tersteeg-Zijderveld, Betty G.M. Jongerius-Gortemaker, Jan A. Post, Holger Brüggemann and Regiane R. Santos

      Version of Record online: 25 AUG 2016 | DOI: 10.1002/ptr.5705

    8. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

      Sepideh Elyasi, Sare Hosseini, Mohammad Reza Niazi Moghadam, Seyed Amir Aledavood and Gholamreza Karimi

      Version of Record online: 23 AUG 2016 | DOI: 10.1002/ptr.5704

    9. Inulin-Type Oligosaccharides Extracted from Yacon Produce Antidepressant-Like Effects in Behavioral Models of Depression

      Lei An, Ji-Chu Yang, Hang Yin, Rui Xue, Qiong Wang, Yu Chen Sun, You-Zhi Zhang and Ming Yang

      Version of Record online: 19 AUG 2016 | DOI: 10.1002/ptr.5698

  13. Reviews

    1. Overview of Oroxylin A: A Promising Flavonoid Compound

      Lu Lu, Qinglong Guo and Li Zhao

      Version of Record online: 19 AUG 2016 | DOI: 10.1002/ptr.5694

  14. Research Articles

    1. Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-α and IL-β Through PI3K/Akt/NF-kb Signaling Pathways

      Min Ho Han, Won Sup Lee, Arulkumar Nagappan, Su Hyun Hong, Ji Hyun Jung, Cheol Park, Hye Jung Kim, Gi-Young Kim, GonSup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong and Yung Hyun Choi

      Version of Record online: 18 AUG 2016 | DOI: 10.1002/ptr.5688

    2. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B

      Xin Liu, Da-Wei Chen, Xue Wu, Zhenying Zhao, Zhi-Wei Fu, Chun-Ting Huang, Li-Xin Ye, Zuo Du, Yang Yu, Zhong-Ze Fang and Hong-Zhi Sun

      Version of Record online: 18 AUG 2016 | DOI: 10.1002/ptr.5697

    3. Plumbagin Enhances Tamoxifen Sensitivity and Inhibits Tumor Invasion in Endocrine Resistant Breast Cancer through EMT Regulation

      Nithidol Sakunrangsit, Nuttiya Kalpongnukul, Trairak Pisitkun and Wannarasmi Ketchart

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5702

  15. Reviews

    1. Progress in the Development and Applicability of Potential Medicinal Plant Extract-Conjugated Polymeric Constructs for Wound Healing and Tissue Regeneration

      Urmimala Das, Sudhanshu Shekhar Behera, Sandeep Singh, Syed Ibrahim Rizvi and Abhishek Kumar Singh

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5700

  16. Research Articles

    1. Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells

      M. Prata-Sena, A.A. Ramos, S. Buttachon, B. Castro-Carvalho, P. Marques, T. Dethoup, A. Kijjoa and E. Rocha

      Version of Record online: 17 AUG 2016 | DOI: 10.1002/ptr.5696

  17. Reviews

    1. Berberis Vulgaris and Berberine: An Update Review

      Mohsen Imenshahidi and Hossein Hosseinzadeh

      Version of Record online: 16 AUG 2016 | DOI: 10.1002/ptr.5693

  18. Research Articles

    1. Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

      Fatemeh Forouzanfar, Hossein Hosseinzadeh, Alireza Ebrahimzadeh Bideskan and Hamid R. Sadeghnia

      Version of Record online: 12 AUG 2016 | DOI: 10.1002/ptr.5701

    2. Magnolol Enhances Hippocampal Neurogenesis and Exerts Antidepressant-Like Effects in Olfactory Bulbectomized Mice

      Nobuaki Matsui, Haruka Akae, Nana Hirashima, Yuki Kido, Satoshi Tanabe, Mayumi Koseki, Yoshiyasu Fukuyama and Masaaki Akagi

      Version of Record online: 11 AUG 2016 | DOI: 10.1002/ptr.5695

  19. Short Communications

    1. Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats

      Ying Deng, Yu-fei Mo, Xin-meng Chen, Lv-zhao Zhang, Chao-feng Liao, Yu Song and Chenshu Xu

      Version of Record online: 4 AUG 2016 | DOI: 10.1002/ptr.5691

  20. Research Articles

    1. Obovatol Induces Apoptosis in Non-small Cell Lung Cancer Cells via C/EBP Homologous Protein Activation

      Heejeong Kim, Eun Ah Shin, Chang Geun Kim, Dae Young Lee, Bonglee Kim, Nam-In Baek and Sung-Hoon Kim

      Version of Record online: 4 AUG 2016 | DOI: 10.1002/ptr.5690

    2. In Vitro Assessment of Plants Growing in Cuba Belonging to Solanaceae Family Against Leishmania amazonensis

      Lianet Monzote, Jenny Jiménez, Osmany Cuesta-Rubio, Ingrid Márquez, Yamile Gutiérrez, Cláudia Quintino da Rocha, Mary Marchi, William N. Setzer and Wagner Vilegas

      Version of Record online: 2 AUG 2016 | DOI: 10.1002/ptr.5681

    3. Synergistic Effect of SH003 and Doxorubicin in Triple-negative Breast Cancer

      Sang-Mi Woo, Ah Jeong Kim, Youn Kyung Choi, Young Cheol Shin, Sung-Gook Cho and Seong-Gyu Ko

      Version of Record online: 1 AUG 2016 | DOI: 10.1002/ptr.5687

    4. Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling

      Boram Kim, Narae Jung, Sanghun Lee, Jae Kyung Sohng and Hye Jin Jung

      Version of Record online: 29 JUL 2016 | DOI: 10.1002/ptr.5689

    5. Silibinin Inhibits Neutrophilic Inflammation and Mucus Secretion Induced by Cigarette Smoke via Suppression of ERK-SP1 Pathway

      Ji-Won Park, Na-Rae Shin, In-Sik Shin, Ok-Kyoung Kwon, Joong-Sun Kim, Sei-Ryang Oh, Jae-hong Kim and Kyung-Seop Ahn

      Version of Record online: 29 JUL 2016 | DOI: 10.1002/ptr.5686

    6. Effects of Ginkgo Biloba Extract EGb-761 on Neuropathic Pain in Mice: Involvement of Opioid System

      Chao Zhu, Wei Li, Fan Xu, Mo Li, Liu Yang, Xue-Yu Hu, Zheng-Xu Ye, Zhe Wang and Zhuo-Jing Luo

      Version of Record online: 25 JUL 2016 | DOI: 10.1002/ptr.5685

    7. Bacopa monnieri-Induced Protective Autophagy Inhibits Benzo[a]pyrene-Mediated Apoptosis

      Durgesh Nandini Das, Prajna Paramita Naik, Aditi Nayak, Prashanta Kumar Panda, Subhadip Mukhopadhyay, Niharika Sinha and Sujit K Bhutia

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/ptr.5682

  21. Reviews

    1. Pharmacological Effects of Capparis spinosa L.

      Seyed Fazel Nabavi, Filippo Maggi, Maria Daglia, Solomon Habtemariam, Luca Rastrelli and Seyed Mohammad Nabavi

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5684

  22. Research Articles

    1. Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes

      Min-Jung Seo, Young-Jin Seo, Cheol-Ho Pan, Ok-Hwan Lee, Kui-Jin Kim and Boo-Yong Lee

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5683

      Thumbnail image of graphical abstract

      We provide evidence that fucoxanthin suppresses protein levels of the adipogenic transcription factors and lipogenesis-associated enzymes in 3T3-L1. The reactive oxygen species (ROS) producing enzyme NOX4 and the nicotinamide adenine dinucleotide phosphate-generating enzyme glucose-6-phosphate dehydrogenase is also decreased in 3T3-L1 treated with fucoxanthin. Moreover, fucoxanthin inhibits the accumulation of intracellular lipid and the production of ROS in high-fat diet-induced obese zebrafish model. Therefore, our data suggest that fucoxanthin inhibits lipid accumulation and ROS production by controlling adipogenic factors and ROS-regulating enzymes in vitro and in vivo.

    2. You have free access to this content
      A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study

      S. Shamshad Begum, H. K. Jayalakshmi, H. G. Vidyavathi, G. Gopakumar, Issac Abin, Maliakel Balu, K. Geetha, S. V. Suresha, M. Vasundhara and I. M. Krishnakumar

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5680

  23. Reviews


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