Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB
Young Sook Yun, Miki Tajima, Shigeru Takahashi, Yuji Takahashi, Mariko Umemura, Haruo Nakano, Hyun Sun Park and Hideshi Inoue
Version of Record online: 8 JUL 2016 | DOI: 10.1002/ptr.5676
Lycoricidine and lycoricidinol, from methanol extract of Lycoris sanguineas uppressed the expression of a reporter gene under the control of cAMP response element and also prevented increases in the endogenous levels of phosphorylated cAMP response element-binding protein and phosphoenolpyruvate carboxykinase mRNA expression. These results suggest that lycoricidine and lycoricidinol suppress cytosolic phosphoenolpyruvate carboxykinase expression by inhibiting the phosphorylation of cAMP response element-binding protein and may thus have the potential to prevent excessive gluconeogenesis in type 2 diabetes.