Phytotherapy Research

Cover image for Vol. 30 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Elizabeth M. Williamson, Angelo A Izzo, Sung Hoon-Kim and Rajan Radhakrishnan

Impact Factor: 2.694

ISI Journal Citation Reports © Ranking: 2015: 28/59 (Chemistry Medicinal); 94/253 (Pharmacology & Pharmacy)

Online ISSN: 1099-1573


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  1. Research Articles

    1. Effects of Ginkgo Biloba Extract EGb-761 on Neuropathic Pain in Mice: Involvement of Opioid System

      Chao Zhu, Wei Li, Fan Xu, Mo Li, Liu Yang, Xue-Yu Hu, Zheng-Xu Ye, Zhe Wang and Zhuo-Jing Luo

      Version of Record online: 25 JUL 2016 | DOI: 10.1002/ptr.5685

    2. Bacopa monnieri-Induced Protective Autophagy Inhibits Benzo[a]pyrene-Mediated Apoptosis

      Durgesh Nandini Das, Prajna Paramita Naik, Aditi Nayak, Prashanta Kumar Panda, Subhadip Mukhopadhyay, Niharika Sinha and Sujit K Bhutia

      Version of Record online: 19 JUL 2016 | DOI: 10.1002/ptr.5682

    3. The Water Fraction of Calendula officinalis Hydroethanol Extract Stimulates In Vitro and In Vivo Proliferation of Dermal Fibroblasts in Wound Healing

      Manikarna Dinda, Swagata Mazumdar, Saurabh Das, Durba Ganguly, Uma B Dasgupta, Ananya Dutta, Kuladip Jana and Parimal Karmakar

      Version of Record online: 18 JUL 2016 | DOI: 10.1002/ptr.5678

  2. Reviews

    1. Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Cognitive Outcomes

      Lin Dong, Brian H May, Mei Feng, Anna J Hyde, Hsiewe Ying Tan, Xinfeng Guo, Anthony Lin Zhang, Chuanjian Lu and Charlie Changli Xue

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/ptr.5679

    2. Pharmacological Effects of Capparis spinosa L.

      Seyed Fazel Nabavi, Filippo Maggi, Maria Daglia, Solomon Habtemariam, Luca Rastrelli and Seyed Mohammad Nabavi

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5684

  3. Research Articles

    1. Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes

      Min-Jung Seo, Young-Jin Seo, Cheol-Ho Pan, Ok-Hwan Lee, Kui-Jin Kim and Boo-Yong Lee

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5683

      Thumbnail image of graphical abstract

      We provide evidence that fucoxanthin suppresses protein levels of the adipogenic transcription factors and lipogenesis-associated enzymes in 3T3-L1. The reactive oxygen species (ROS) producing enzyme NOX4 and the nicotinamide adenine dinucleotide phosphate-generating enzyme glucose-6-phosphate dehydrogenase is also decreased in 3T3-L1 treated with fucoxanthin. Moreover, fucoxanthin inhibits the accumulation of intracellular lipid and the production of ROS in high-fat diet-induced obese zebrafish model. Therefore, our data suggest that fucoxanthin inhibits lipid accumulation and ROS production by controlling adipogenic factors and ROS-regulating enzymes in vitro and in vivo.

    2. A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study

      S. Shamshad Begum, H. K. Jayalakshmi, H. G. Vidyavathi, G. Gopakumar, Issac Abin, Maliakel Balu, K. Geetha, S. V. Suresha, M. Vasundhara and I. M. Krishnakumar

      Version of Record online: 13 JUL 2016 | DOI: 10.1002/ptr.5680

  4. Reviews

    1. Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

      Roghayeh Javan, Mahdi Yousefi, Seyed-Mohammad Nazari, Parastoo Amiri, Alireza Mosavi-Jarrahi, Parvaneh Modiramani and Hamideh Naghedi-Baghdar

      Version of Record online: 10 JUL 2016 | DOI: 10.1002/ptr.5675

  5. Research Articles

  6. Research articles

    1. Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB

      Young Sook Yun, Miki Tajima, Shigeru Takahashi, Yuji Takahashi, Mariko Umemura, Haruo Nakano, Hyun Sun Park and Hideshi Inoue

      Version of Record online: 8 JUL 2016 | DOI: 10.1002/ptr.5676

      Thumbnail image of graphical abstract

      Lycoricidine and lycoricidinol, from methanol extract of Lycoris sanguineas uppressed the expression of a reporter gene under the control of cAMP response element and also prevented increases in the endogenous levels of phosphorylated cAMP response element-binding protein and phosphoenolpyruvate carboxykinase mRNA expression. These results suggest that lycoricidine and lycoricidinol suppress cytosolic phosphoenolpyruvate carboxykinase expression by inhibiting the phosphorylation of cAMP response element-binding protein and may thus have the potential to prevent excessive gluconeogenesis in type 2 diabetes.

  7. Reviews

    1. The Mechanisms of Pharmacological Activities of Ophiocordyceps sinensis Fungi

      Jin Xu, Ying Huang, Xiang-Xiang Chen, Shuai-Chao Zheng, Peng Chen and Ming-He Mo

      Version of Record online: 3 JUL 2016 | DOI: 10.1002/ptr.5673

  8. Research Articles

    1. The Suppressive Effects of the Petroleum Ether Fraction from Atractylodes lancea (Thunb.) DC. On a Collagen-Induced Arthritis Model

      Renping Liu, Enwei Tao, Shuwen Yu, Bo Liu, Lingman Dai, Liangyu Yu, Yifeng Xiong, Ruijun Fu, Lang Lei and Xiaoping Lai

      Version of Record online: 3 JUL 2016 | DOI: 10.1002/ptr.5671

    2. The Impact of Cocoa Flavanols on Cardiovascular Health

      Julia Vlachojannis, Paul Erne, Benno Zimmermann and Sigrun Chrubasik-Hausmann

      Version of Record online: 1 JUL 2016 | DOI: 10.1002/ptr.5665

  9. Short Communications

    1. Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells

      Kashif M. Khan, Lutfun Nahar, Afaf Al-Groshi, Alexandra G. Zavoianu, Andrew Evans, Nicola M. Dempster, Jean D. Wansi, Fyaz M. D. Ismail, Abdul Mannan and Satyajit D. Sarker

      Version of Record online: 1 JUL 2016 | DOI: 10.1002/ptr.5672

  10. Research Articles

    1. Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis

      Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu and Ganzhen Deng

      Version of Record online: 23 JUN 2016 | DOI: 10.1002/ptr.5666

    2. Methanol Extract of Bitter Melon Alleviates UVB-Induced MMPs Expression via MAP Kinase and AP-1 Signaling in Human Dermal Fibroblasts in vitro

      Hyun Ji Lee, Eunson Hwang, Bom Park, Mengyang Zhang, Zheng-wang Sun, Do-Gyeong Lee, Sang-Yong Park and Tae Hoo Yi

      Version of Record online: 22 JUN 2016 | DOI: 10.1002/ptr.5656

  11. Reviews

    1. Therapeutic Potential of Essential Oils Focusing on Diterpenes

      Md. Torequl Islam, Ana Maria Oliveira Ferreira da Mata, Raí Pablo Sousa de Aguiar, Marcia Fernanda Correia Jardim Paz, Marcus Vinícius Oliveira Barros de Alencar, Paulo Michel Pinheiro Ferreira and Ana Amélia de Carvalho Melo-Cavalcante

      Version of Record online: 16 JUN 2016 | DOI: 10.1002/ptr.5652

      Thumbnail image of graphical abstract

      Dimethayllyl-pyrophosphate (DAPP) is the ultimate product of the pyryvate-glyceraldehyde-3-P and 2-acetyl-Co-A pathways, as it can reversibly turn to isopentenyl-pyrophosphate (IPP) moiety. These two then undergoing a head-tail condensation in the presence of geranyl-pyrophosphate (GPP) synthase form GPP. Upon a step-wise addition of further IPPs, they ultimately form diterpenes.

  12. Research Articles

    1. Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts

      Adnan Amin, Emmy Tuenter, Vassiliki Exarchou, Atul Upadhyay, Paul Cos, Louis Maes, Sandra Apers and Luc Pieters

      Version of Record online: 10 JUN 2016 | DOI: 10.1002/ptr.5663

    2. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial

      Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi and Sin Gon Kim

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5664

    3. Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

      Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji and Tahereh Farkhondeh

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5638

  13. Reviews

    1. A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch

      Shefton Parker, Brian May, Claire Zhang, Anthony Lin Zhang, Chuanjian Lu and Charlie Changli Xue

      Version of Record online: 9 JUN 2016 | DOI: 10.1002/ptr.5653

  14. Research Articles

    1. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

      Sepideh Rahmani, Sedigheh Asgary, Gholamreza Askari, Mahtab Keshvari, Mahdi Hatamipour, Awat Feizi and Amirhossein Sahebkar

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/ptr.5659

    2. Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients—A Pilot Study

      Andrea Čabarkapa, Lada Živković, Sunčica Borozan, Mirjana Zlatković-Švenda, Dragana Dekanski, Ivan Jančić, Marija Radak-Perović, Vladan Bajić and Biljana Spremo-Potparević

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/ptr.5662

  15. Reviews

  16. Research Articles

    1. An Hydroalcoholic Chamomile Extract Modulates Inflammatory and Immune Response in HT29 Cells and Isolated Rat Colon

      Luigi Menghini, Claudio Ferrante, Lidia Leporini, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Giorgio Pintore, Michele Vacca, Giustino Orlando and Luigi Brunetti

      Version of Record online: 30 MAY 2016 | DOI: 10.1002/ptr.5655

    2. Attenuation of Adhesion, Biofilm Formation and Quorum Sensing of Campylobacter jejuni by Euodia ruticarpa

      Katja Bezek, Marija Kurinčič, Elvira Knauder, Anja Klančnik, Peter Raspor, Franz Bucar and Sonja Smole Možina

      Version of Record online: 27 MAY 2016 | DOI: 10.1002/ptr.5658

    3. The Prokinetic, Laxative, and Antidiarrheal Effects of Morus nigra: Possible Muscarinic, Ca2+ Channel Blocking, and Antimuscarinic Mechanisms

      Anam Akhlaq, Malik Hassan Mehmood, Abdul Rehman, Zohaib Ashraf, Sadia Syed, Samira Ahmed Bawany, Anwarul-Hassan Gilani, Maimoona Ilyas and Bina Shaheen Siddiqui

      Version of Record online: 27 MAY 2016 | DOI: 10.1002/ptr.5641

  17. Reviews

    1. Chemistry, Pharmacology and Health Benefits of Anthocyanins

      Antonella Smeriglio, Davide Barreca, Ersilia Bellocco and Domenico Trombetta

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/ptr.5642

  18. Research Articles

    1. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia

      Shima Hirako, Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Tomoko Nakano, Kenji Imai, Hua Li, Shinya Toyokuni and Fumitaka Kikkawa

      Version of Record online: 25 MAY 2016 | DOI: 10.1002/ptr.5645

  19. Reviews

    1. Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

      Igor A. Schepetkin, Andrew G. Ramstead, Liliya N. Kirpotina, Jovanka M. Voyich, Mark A. Jutila and Mark T. Quinn

      Version of Record online: 24 MAY 2016 | DOI: 10.1002/ptr.5648

  20. Research Articles

  21. Reviews

    1. You have free access to this content
    2. The Chemistry and Biological Activities of Mimosine: A Review

      Binh Cao Quan Nguyen and Shinkichi Tawata

      Version of Record online: 23 MAY 2016 | DOI: 10.1002/ptr.5636

      Thumbnail image of graphical abstract
      • Mimosine has been evolved as a multi-functional compound.
      • Mimosine has been found as a leading compound for development of protein-activated kinase 1 inhibitors.
      • The new evidences to explain why mimosine is implicated in regenerative dentistry, periodontal regeneration, oral surgery, and phytoremediation.
      • The review is to bridge the gaps between the chemistry and recognized biological activities of mimosine.
  22. Research Articles

  23. Reviews

    1. Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

      Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, Huyiligeqi and Jian Ni

      Version of Record online: 18 MAY 2016 | DOI: 10.1002/ptr.5631

    2. Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials

      Ji Young Lee, Seung Ah Jun, Sung Shin Hong, Yo Chan Ahn, Dong Soo Lee and Chang Gue Son

      Version of Record online: 16 MAY 2016 | DOI: 10.1002/ptr.5647

  24. Research Articles

    1. The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats

      Stanislava Jankyova, Dominika Rubintova, Lenka Janosikova, Peter Panek, Tatiana Foltanova and Eva Kralova

      Version of Record online: 11 MAY 2016 | DOI: 10.1002/ptr.5639

    2. Acetonic Extract from the Feijoa sellowiana Berg. Fruit Exerts Antioxidant Properties and Modulates Disaccharidases Activities in Human Intestinal Epithelial Cells

      Fabio Turco, Ilaria Palumbo, Paolo Andreozzi, Giovanni Sarnelli, Francesca De Ruberto, Giuseppe Esposito, Adriana Basile and Rosario Cuomo

      Version of Record online: 10 MAY 2016 | DOI: 10.1002/ptr.5629

    3. Polyphenolic Compounds and Antioxidant Activity of Cold-Pressed Seed Oil from Finola Cultivar of Cannabis sativa L.

      Antonella Smeriglio, Enza M. Galati, Maria T. Monforte, Francesco Lanuzza, Valeria D'Angelo and Clara Circosta

      Version of Record online: 14 APR 2016 | DOI: 10.1002/ptr.5623


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