ChemBioChem

Cover image for Vol. 17 Issue 3

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

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January 27, 2016

Very Important Paper: Enhancing DNA Crystal Durability through Chemical Crosslinking

Diana Zhang & Paul J. Paukstelis*

Three-dimensional DNA crystals are promising materials for nanotechnology applications. However, these applications may be limited by features inherent to the DNA lattice, including low thermal stability, high cation requirements, and nuclease sensitivity. To overcome these problems D. Zhang & P.J. Paukstelis (University of Maryland) have developed a post-crystallization crosslinking step that enhances the durability of a model DNA crystal lattice. Crystals crosslinked with nornitrogen mustard show enhanced thermal stability, decreased divalent cation requirements, and almost complete resistance to DNase I. This method for stabilizing DNA crystals may be applicable to other DNA constructs and ultimately improve the usefulness of DNA nanoarchitectures.

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    Carina Doler, Dr. Martina Schweiger, Prof. Dr. Robert Zimmermann and Prof. Dr. Rolf Breinbauer

    Article first published online: 5 FEB 2016 | DOI: 10.1002/cbic.201500501

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    Blocking lipid-metabolizing enzymes: Lipid-metabolizing enzymes represent logical targets for the treatment of dyslipidemia, a major risk factor for type 2 diabetes, atherosclerosis, and other disorders. In this review we summarize the current state of available inhibitors targeting key proteins in neutral lipid metabolism, with a focus on metabolic lipases, acyltransferases, and fatty-acid-binding proteins.

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    Julian Seidel, Dr. Cordula Klockenbusch and Prof. Dr. Dirk Schwarzer

    Article first published online: 5 FEB 2016 | DOI: 10.1002/cbic.201500611

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  3. Identification of Sequence Specificity of 5-Methylcytosine Oxidation by Tet1 Protein with High-Throughput Sequencing

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    Article first published online: 5 FEB 2016 | DOI: 10.1002/cbic.201500646

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