ChemBioChem

Cover image for Vol. 19 Issue 4

Editor: Ruben Ragg; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Recently Published Issues

See all

Latest News

Browse more news

Find Us on FacebookFollow us on Twitter

February 15, 2018

Very Important Paper: Mechanism-based Inhibitor of DNA Cytosine-5 Methyltransferase (DNMT) via a SNAr Reaction with an Oligodeoxyribonucleotide Containing 2-Amino-4-Halopyridine-C-Nucleoside (dXP)

Very Important Paper: Mechanism-based Inhibitor of DNA Cytosine-5 Methyltransferase (DNMT) via a SNAr Reaction with an Oligodeoxyribonucleotide Containing 2-Amino-4-Halopyridine-C-Nucleoside (dXP) Kousuke Sato,* Yuma Kunitomo, Yukiko Kasai, Shohei Utsumi, Isao Suetake, Shoji Tajima, Satoshi Ichikawa, Akira Matsuda

Inhibition of human DNA cytosine-5 methyltransferase (DNMT), which is responsible for generating 5-methylcytosine in CpG sequences, is an effective strategy to treat various cancers. Sato (Health Sciences University of Hokkaido, Japan) and co-workers describe the design, synthesis, and evaluation of the properties of 2-amino-4-halopyridine-C-nucleosides (dXP) and oligodeoxyribonucleotides (ODNs) containing dXP as a novel mechanism-based inhibitor of DNMTs. The ODN forms a complex with DNMTs via covalent bonding through a nucleophilic aromatic substitution (SNAr) reaction. This study suggests that dXP in a CpG sequence of DNA could serve as a potential nucleic acid drug lead in cancer chemotherapy and a useful chemical probe for epigenetic studies.

Your Comment...

[Browse more news]

Recently Published Articles

  1. Analyzing Xyloglucan Endotransglycosylases by Incorporating Synthetic Oligosaccharides into Plant Cell Walls

    Dr. Colin Ruprecht, Pietro Dallabernardina, Peter J. Smith, Dr. Breeanna R. Urbanowicz and Dr. Fabian Pfrengle

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/cbic.201700638

    Thumbnail image of graphical abstract

    A different brick in the wall: Synthetic oligosaccharides obtained by automated glycan assembly were enzymatically incorporated into polysaccharides printed as microarrays as well as intact plant cell walls by the action of native xyloglucan endotransglycosylases. The differential incorporation of the oligosaccharides provided detailed information on the substrate specificities of these important plant cell wall remodeling enzymes.

  2. Improvement in the Photobiological Hydrogen Production of Aggregated Chlorella by Dimethyl Sulfoxide

    Lei Shu, Dr. Wei Xiong, Changyu Shao, Tingting Huang, Pengqiang Duan, Kun Liu, Prof. Dr. Xurong Xu, Prof. Dr. Weimin Ma and Prof. Dr. Ruikang Tang

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/cbic.201700637

    Thumbnail image of graphical abstract

    A deep breath: The presence of dimethyl sulfoxide (DMSO) in an aqueous environment significantly enhances the photobiological H2 production efficiency of Chlorella aggregates. DMSO, as an organic small molecule, stimulates cellular respiration, which reduces the oxygen content inside the aggregates and enhances hydrogenase activity.

  3. Genome Mining of the Lipopeptide Biosynthesis of Paenibacillus polymyxa E681 in Combination with Mass Spectrometry: Discovery of the Lipoheptapeptide Paenilipoheptin

    Dr. Joachim Vater, Stefanie Herfort, Dr. Joerg Doellinger, Max Weydmann, Prof. Dr. Rainer Borriss and Dr. Peter Lasch

    Version of Record online: 23 FEB 2018 | DOI: 10.1002/cbic.201700615

    Thumbnail image of graphical abstract

    With a little pep: The organization of the phn gene cluster coding for the biosynthesis of lipopeptides is analyzed, leading to the discovery of novel lipoheptapeptides, named paenilipoheptins. Detected and characterized by MS, they are found to be cyclic compounds that contain a C12–13 β-amino fatty acid that is integrated into the peptide ring.

  4. Spatial Control of Inducible Cre-Mediated Recombination Using Cyanine Photocages

    Alexander Gorka, Tsuyoshi Yamamoto, Jianjian Zhu and Martin Schnermann

    Accepted manuscript online: 22 FEB 2018 10:03PM EST | DOI: 10.1002/cbic.201800061

  5. A Modular Nanoswitch for Mix-and-Detect Protein Assay Based on Binding-Induced Cascade Dissociation of Kissing Complex

    Yishen Tian, Shanshan Zhang, Dr. Li Wang and Prof. Shufeng Liu

    Version of Record online: 22 FEB 2018 | DOI: 10.1002/cbic.201700649

    Thumbnail image of graphical abstract

    Pucker up! A modular, kissing-complex-based nanoswitch is proposed for the versatile, rapid, homogeneous, and sensitive detection of proteins. The nanoswitch operates according to a simple mix-and-detect format, with the formation of a kissing complex for fluorescence quenching followed by protein-binding-induced dissociation for fluorescence recovery.

SEARCH

SEARCH BY CITATION