ChemBioChem

Cover image for Vol. 17 Issue 16

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Recently Published Issues

See all

Latest News

Browse more news

August 01, 2016

Very Important Paper: Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins

Emmanuelle Thinon, Avital Percher, Howard C. Hang*

Dietary unsaturated fatty acids, such as oleic acid, have been shown to be covalently incorporated into a few eukaryotic proteins but the generality and diversity of unsaturated fatty acid modifications was not yet known. Now, H.C. Hang (The Rockefeller University, USA) and co-workers synthesized unsaturated fatty acid reporters that effectively induced lipid droplets and were site-specifically incorporated onto known fatty-acylated proteins. Quantitative proteomic analysis revealed that unsaturated fatty acids in mammalian cells modify similar protein targets to saturated fatty acids, which suggests that unsaturated fatty acids may directly modify many proteins to exert their unique and often beneficial physiological effects in vivo.

Your Comment...

[Browse more news]

Recently Published Articles

  1. An Fc–Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor

    Po-Yuan Hsiao, Dr. Jay H. Kalin, Im-Hong Sun, Dr. Mohammed N. Amin, Dr. Ying-Chun Lo, Dr. Meng-Jung Chiang, John Giddens, Dr. Polina Sysa-Shah, Prof.Dr. Kathleen Gabrielson, Prof. Dr. Lai-Xi Wang, Prof. Dr. Jonathan D. Powell and Prof. Dr. Philip A. Cole

    Version of Record online: 26 AUG 2016 | DOI: 10.1002/cbic.201600337

    Thumbnail image of graphical abstract

    Bigger is better: By using a semisynthetic approach, an Fc–small molecule conjugate, Fc–ZM, was developed for targeted inhibition of the adenosine 2A receptor (A2AR). Fc–ZM displayed superior pharmacologic properties compared to ZM alone and was able to functionally interact with A2AR and Fc receptors, present on lymphocytes and antigen-presenting cells, respectively.

  2. BioCatNet: a database system for the integration of enzyme sequences and biocatalytic experiments

    Patrick Buchholz, Constantin Vogel, Waldemar Reusch, Martina Pohl, Dörte Rother, Antje Spieß and Jürgen Pleiss

    Accepted manuscript online: 26 AUG 2016 03:55AM EST | DOI: 10.1002/cbic.201600462

  3. Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by High-Throughput Sequencing

    Dr. Anandhakumar Chandran, Dr. Junetha Syed, Dr. Yue Li, Shinsuke Sato, Dr. Toshikazu Bando and Prof. Hiroshi Sugiyama

    Version of Record online: 25 AUG 2016 | DOI: 10.1002/cbic.201600274

    Thumbnail image of graphical abstract

    Uncrossed: Effects of artificial transcription-activating small molecules binding to the human genome. Our reported SAHA PIP library showed unique gene-set activation. But the mechanism is uncertain with the complex human genome. Therefore, we developed a high-throughput sequencing method to address this without crosslinking the small molecules.

  4. Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Cross-Links, and Photo-Release of Coumarin Moiety

    Huabing Sun, Heli Fan, Hyeyoung Eom and Xiaohua Peng

    Accepted manuscript online: 25 AUG 2016 06:10AM EST | DOI: 10.1002/cbic.201600240

  5. Chemical Probes to Directly Profile Palmitoleoylation of Proteins

    Baohui Zheng, Gopala Jarugumilli, Baoen Chen and Xu Wu

    Accepted manuscript online: 25 AUG 2016 06:10AM EST | DOI: 10.1002/cbic.201600403

SEARCH

SEARCH BY CITATION