ChemBioChem

Cover image for Vol. 17 Issue 8

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Recently Published Issues

See all

Latest News

Browse more news

April 22, 2016

Very Important Paper: A Three-Enzyme Pathway with an Optimised Geometric Arrangement to Facilitate Substrate Transfer

Minghui Liu, Jinglin Fu, Xiaodong Qi, Shaun Wootten, Neal W. Woodbury, Yan Liu, Hao Yan*

Efficient coupling of substrates between enzymes is critical for metabolic functions. Now, H. Yan (Arizona State University) and co-workers used DNA nanostructures to organize a three-enzyme pathway for investigating how the pathway activity depended on the spatial arrangements of the enzymes. Unlike previous studies, the overall pathway activity relied less on the interenzyme distance, but was affected more by the geometric arrangement of the enzymes in a relatively small range of 10-30 nm. The pathway intermediates were also quickly depleted through efficient reaction coupling. These studies will provide new insights into the design of artificial multi-enzyme systems for biocatalysis and therapeutics.

Your Comment...

[Browse more news]

Recently Published Articles

  1. Expanding substrate promiscuity by engineering novel adenylating-methylating NRPS bifunctional enzyme

    Sanjib K. Shrestha and Sylvie Garneau-Tsodikova

    Accepted manuscript online: 29 APR 2016 01:15PM EST | DOI: 10.1002/cbic.201600234

  2. Biocatalytic properties and structural analysis of eugenol oxidase from Rhodococcus jostii RHA1: a versatile oxidative biocatalyst

    Quoc-Thai Nguyen, Gonzalo De Gonzalo, Claudia Binda, Ana Rioz, Andrea Mattevi and Marco Fraaije

    Accepted manuscript online: 28 APR 2016 09:53AM EST | DOI: 10.1002/cbic.201600148

  3. Small Protein Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells

    Ning Zhao, Siyu Liu, Qike Jiang, Tian Lan, Zhen Cheng and Hongguang Liu

    Accepted manuscript online: 28 APR 2016 09:51AM EST | DOI: 10.1002/cbic.201600219

  4. Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain

    Oliver S Shafaat, Jay R Winkler, Harry B Gray and Dennis Dougherty

    Accepted manuscript online: 28 APR 2016 09:51AM EST | DOI: 10.1002/cbic.201600230

  5. Nucleoside-Based Diarylethene Photoswitches: Synthesis and Photochromic Properties

    Hai-Xia Wang, Dan-Dan Xi, Ming-Sheng Xie, Hui-Xuan Wang, Gui-Rong Qu and Haiming Guo

    Accepted manuscript online: 28 APR 2016 09:48AM EST | DOI: 10.1002/cbic.201600171

SEARCH

SEARCH BY CITATION