Cover image for Vol. 16 Issue 14

Editor: Peter Gölitz; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

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September 21, 2015

Very Important Paper: Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433

Pauline Peltier-Pain, Shanteri Singh, Jon S. Thorson*

While a number of bacterial natural products contain both uniquely functionalized five- and six-carbon sugars, there has not been extensive investigation into the biosynthesis of five-carbon sugars. Now, J. S. Thorson (University of Kentucky, USA) and co-workers report the study of key enzymes involved in the early steps of five-carbon sugar modification in which unique real-time nuclear magnetic resonance methods serve as a primary basis for biochemical analysis. Their studies reveal, for the first time, evidence to suggest that the same enzymes may be employed in modifying both five-carbon and six-carbon sugars, raising the question of whether enzyme conservation is a common phenomenon or unique to the selected model.

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    Article first published online: 6 OCT 2015 | DOI: 10.1002/cbic.201500371

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