Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
November 07, 2013
Upcoming Synthetic Biology Events
Join the Associate Editor of ChemBioChem Dr. Meghan Campbell at two upcoming conferences on Synthetic Biology. The first is New Frontiers in Synthetic Life in Nijmegen, NL (November 11--12, 2013) and the second is the International Symposium on Synthetic Biology in Heidelberg, DE (December 9--11, 2013). Meghan will be there to discuss publishing with ChemBioChem and an upcoming special issue of the journal focused on Synthetic Biology. Here is a link to the latest articles from ChemBioChem in this rapidly emerging field.
Recently Published Articles
- Structure-Dependent Binding of Arylimidamides to the DNA Minor Groove
Dr. Yun Chai, Dr. Manoj Munde, Dr. Arvind Kumar, Leah Mickelson, Dr. Sen Lin, Dr. Nancy H. Campbell, Dr. Moloy Banerjee, Dr. Senol Akay, Dr. Zongying Liu, Dr. Abdelbasset A. Farahat, Dr. Raja Nhili, Sabine Depauw, Prof. Marie-Hélène David-Cordonnier, Prof. Stephen Neidle, Prof. W. David Wilson and Prof. David W. Boykin
Article first published online: 9 DEC 2013 | DOI: 10.1002/cbic.201300622
Size, charge and polarity: The first detailed study of DNA complexes of modified AIAs shows a surprisingly large variation in DNA interactions with relatively small changes in the structure. Crystallographic analysis of DB1880 bound to an AATT site shows how it fits to the minor groove with big piperidinyl substituents.
- A Synthetic Oligonucleotide Model for Evaluating the Oxidation and Crosslinking Propensities of Natural Furan-Modified DNA
Lieselot L. G. Carrette and Prof. Annemieke Madder
Article first published online: 9 DEC 2013 | DOI: 10.1002/cbic.201300612
Natural ROS scavengers: To elucidate the apparent discrepancies between our crosslinking approach, inspired by furan toxicity, and the beneficial effects of naturally occurring furan modifications in DNA, short oligonucleotides containing the natural modification were synthesised through a quick postsynthetic modification and tested for their oxidation and crosslinking propensities.
- Cellular Internalisation of an Inositol Phosphate Visualised by Using Fluorescent InsP5
Dr. Andrew M. Riley, Dr. Sabine Windhorst, Dr. Hong-Yin Lin and Prof. Barry V. L. Potter
Article first published online: 6 DEC 2013 | DOI: 10.1002/cbic.201300583
Rapid screening of cellular uptake: A synthetic fluorescent conjugate of myo-inositol pentakisphosphate, FAM-InsP5, is internalised when applied extracellularly to intact cells, and allows direct observation of the time course and extent of uptake to be compared between different cell lines.
- Identification of the First Diphenyl Ether Gene Cluster for Pestheic Acid Biosynthesis in Plant Endophyte Pestalotiopsis fici
Xinxin Xu, Dr. Ling Liu, Dr. Fan Zhang, Dr. Wenzhao Wang, Jinyang Li, Prof. Liangdong Guo, Prof. Yongsheng Che and Prof. Gang Liu
Article first published online: 2 DEC 2013 | DOI: 10.1002/cbic.201300626
Gene identification: The pestheic acid biosynthetic gene (pta) cluster was identified in Pestalotiopsis fici. A dihydrogeodin oxidase gene, ptaE, was essential for diphenyl ether formation, and ptaM encoded a flavin-dependent halogenase catalyzing chlorination in the biosynthesis.
- Specificity of a UDP-GalNAc Pyranose–Furanose Mutase: A Potential Therapeutic Target for Campylobacter jejuni Infections
Dr. Myles B. Poulin, Yun Shi, Carla Protsko, Dr. Sean A. Dalrymple, Prof. David A. R. Sanders, Prof. B. Mario Pinto and Prof. Todd L. Lowary
Article first published online: 2 DEC 2013 | DOI: 10.1002/cbic.201300653
It takes two: UV–visible spectroscopy, X-ray crystallography, saturated transfer difference NMR spectroscopy, molecular dynamics and CORCEMA-ST calculations were used to characterize a bifunctional pyranose–furanose mutase, UNGM, from Campylobacter jejuni 11168. Two arginines play critical roles in controlling the specificity of the enzyme, the first bifunctional pyranose–furanose mutase reported to date.