ChemBioChem
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Editor: Peter Gölitz
Online ISSN: 1439-7633
Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem
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Current Issue:February 13, 2012
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amino acids · antibiotics · antitumor agents · biocatalysis · bioinorganic chemistry · biosynthesis · carbohydrates · click chemistry · DNA · enzyme catalysis · enzymes · fluorescence · fluorescent probes · glycopeptides · hydrolases · inhibitors · medicinal chemistry · membranes · microarrays · natural products · NMR spectroscopy · peptides · peptidomimetics · photochemistry · polyketides · post-translational modifications · protein design · proteins · proteomics · RNA
Recently Published Articles
- Stereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol β
Brian T. Chamberlain, Dr. Vinod K. Batra, Dr. William A. Beard, Anastasia P. Kadina, David D. Shock, Dr. Boris A. Kashemirov, Dr. Charles E. McKenna, Dr. Myron F. Goodman and Dr. Samuel H. Wilson
Article first published online: 7 FEB 2012 | DOI: 10.1002/cbic.201100738
- KlenTaq DNA Polymerase Adopts Unique Recognition States when Encountering Matched, Mismatched, and Abasic Template Sites: An NMR Study
Bastian Holzberger, M. Gabriele Pszolla, Prof. Dr. Andreas Marx and Dr. Heiko M. Möller
Article first published online: 7 FEB 2012 | DOI: 10.1002/cbic.201100802

On the tracks of a DNA polymerase: NMR provides insights into DNA synthesis in a virtually label-free manner and under close-to-physiological conditions. Through the monitoring of the chemical-shift changes of multiple 13C-methyl methionine residues we found unique recognition states for canonical and noncanonical cases, thus indicating enzymatic cycling through distinct paths.
- Covalent Tagging of Phosphorylated Peptides by Phosphate-Specific Deoxyribozymes
Dr. Amit Sachdeva, Dr. Madhavaiah Chandra, Jagadeeswaran Chandrasekar and Prof. Scott K. Silverman
Article first published online: 7 FEB 2012 | DOI: 10.1002/cbic.201200048

Hold your P's: Phosphorylated tyrosine and serine residues in peptides have been modified selectively by DNA catalysts (see graphic). These deoxyribozymes catalyze covalent attachment of an RNA tag to a range of peptide sequences, thus a proof of principle for a new approach to phosphopeptide analysis is established.

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