Cover image for Vol. 16 Issue 13

Editor: Peter Gölitz; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Recently Published Issues

See all

Latest News

Browse more news

July 03, 2015

Very Important Paper: Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

Dennis Wetzl, Marco Berrera, Nicolas Sandon, Dan Fishlock, Martin Ebeling, Michael Müller, Steven Hanlon, Beat Wirz, Hans Iding*

Recent investigations on imine reductases (IREDs) have enriched the toolbox of potential catalysts accessing chiral amines. Now, H. Iding and co-workers (F. Hoffmann-La Roche, Switzerland) describe the characterization of 20 new IREDs, which were identified by using a C-terminal domain clustering of the bacterial protein-sequence space. Each of the enzymes was characterized against a set of nine cyclic imine model substrates. A refined clustering towards putative active-site residues was performed that was consistent with the current screen and previously reported results. Finally, preparative (100 mg scale) experiments with two purified IREDs, IR_20 from Streptomyces tsukubaensis and IR_23 from Streptomyces vidiochromogenes, were carried out.

Your Comment...

[Browse more news]

Recently Published Articles

  1. Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials

    Myles A Mitchell, Anthony A Iannetta, Megan C Jennings, Madison H Fletcher, William M Wuest and Kevin P. C. Minbiole

    Accepted manuscript online: 28 AUG 2015 07:25AM EST | DOI: 10.1002/cbic.201500381

  2. Catalysis of an essential step in vitamin B2 biosynthesis by a consortium of broad spectrum hydrolases

    Sonja Sarge, Ilka Haase, Boris Illarionov, Dietmar Laudert, Hans-Peter Hohmann, Adelbert Bacher and Markus Fischer

    Accepted manuscript online: 28 AUG 2015 07:24AM EST | DOI: 10.1002/cbic.201500352

  3. A Rhizobium radiobacter histidine kinase can employ both Boolean AND and OR logic gates for initiating pathogenesis

    Fang Fang, Yi-Han Lin, B Daniel Pierce and David Lynn

    Accepted manuscript online: 27 AUG 2015 07:10AM EST | DOI: 10.1002/cbic.201500334

  4. Targeted Inhibition of Snail Activity in Breast Cancer Cells by Using a CoIII-Ebox Conjugate

    Luke F. Vistain, Natsuho Yamamoto, Richa Rathore, Peter Cha and Prof. Thomas J. Meade

    Article first published online: 25 AUG 2015 | DOI: 10.1002/cbic.201500289

    Thumbnail image of graphical abstract

    Stalling metastasis: CoIII-Ebox (CAGGTG) conjugates effectively inhibit the activity of the Snail transcription factor in cells. Through this inhibition, many of the metastatic and invasive properties of breast cancer cells can be prevented.

  5. How many biochemistries are available to build a cell?

    Carlos G. Acevedo-Rocha and Dirk Schulze-Makuch

    Accepted manuscript online: 25 AUG 2015 04:26AM EST | DOI: 10.1002/cbic.201500379