ChemBioChem

Cover image for Vol. 13 Issue 8

Editor: Peter Gölitz

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

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amino acids · antibiotics · antitumor agents · biocatalysis · bioinorganic chemistry · biosynthesis · carbohydrates · click chemistry · DNA · enzyme catalysis · enzymes · fluorescence · fluorescent probes · glycopeptides · hydrolases · inhibitors · medicinal chemistry · membranes · microarrays · natural products · NMR spectroscopy · peptides · peptidomimetics · photochemistry · polyketides · post-translational modifications · protein design · proteins · proteomics · RNA

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  1. You have free access to this content
    Preview: ChemBioChem 9/2012 (page 1215)

    Article first published online: 23 MAY 2012 | DOI: 10.1002/cbic.201290032

  2. You have full text access to this OnlineOpen article
    The Complex of Cytochrome f and Plastocyanin from Nostoc sp. PCC 7119 is Highly Dynamic

    Sandra Scanu, Johannes Förster, Dr. Michela G. Finiguerra, Maryam Hashemi Shabestari, Dr. Martina Huber and Prof. Dr. Marcellus Ubbink

    Article first published online: 22 MAY 2012 | DOI: 10.1002/cbic.201200073

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    Brief encounter: Cytochrome f and plastocyanin are redox partners in photosynthesis. Paramagnetic NMR spectroscopy was applied to characterize this complex from the cyanobacterium Nostoc sp. PCC 7119. The results show that the complex cannot be described by a single well-defined state, thus indicating that the interaction is highly dynamic.

  3. Recombinant Production of Isotope-Labeled Peptides and Spontaneous Cyclization of Amino-Terminal Glutamine into Pyroglutamic Acid

    André Mischo, Dr. Oliver Ohlenschläger, Dr. Karl-Heinz Gührs and Dr. Matthias Görlach

    Article first published online: 22 MAY 2012 | DOI: 10.1002/cbic.201200178

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    Spontaneous, but stable: We used the intein system to generate a stable-isotope-labeled peptide. The liberated amino-terminal peptide Gln residue spontaneously converts into pyroglutamate. It might be possible to exploit this conversion to generate and subsequently characterize physiological or disease-relevant pGlu-containing peptides such as truncated Aβ species.

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