Cover image for Vol. 17 Issue 8

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

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April 22, 2016

Very Important Paper: A Three-Enzyme Pathway with an Optimised Geometric Arrangement to Facilitate Substrate Transfer

Minghui Liu, Jinglin Fu, Xiaodong Qi, Shaun Wootten, Neal W. Woodbury, Yan Liu, Hao Yan*

Efficient coupling of substrates between enzymes is critical for metabolic functions. Now, H. Yan (Arizona State University) and co-workers used DNA nanostructures to organize a three-enzyme pathway for investigating how the pathway activity depended on the spatial arrangements of the enzymes. Unlike previous studies, the overall pathway activity relied less on the interenzyme distance, but was affected more by the geometric arrangement of the enzymes in a relatively small range of 10-30 nm. The pathway intermediates were also quickly depleted through efficient reaction coupling. These studies will provide new insights into the design of artificial multi-enzyme systems for biocatalysis and therapeutics.

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