Structure-Dependent Binding of Arylimidamides to the DNA Minor Groove
Dr. Yun Chai, Dr. Manoj Munde, Dr. Arvind Kumar, Leah Mickelson, Dr. Sen Lin, Dr. Nancy H. Campbell, Dr. Moloy Banerjee, Dr. Senol Akay, Dr. Zongying Liu, Dr. Abdelbasset A. Farahat, Dr. Raja Nhili, Sabine Depauw, Prof. Marie-Hélène David-Cordonnier, Prof. Stephen Neidle, Prof. W. David Wilson and Prof. David W. Boykin
Article first published online: 9 DEC 2013 | DOI: 10.1002/cbic.201300622
Size, charge and polarity: The first detailed study of DNA complexes of modified AIAs shows a surprisingly large variation in DNA interactions with relatively small changes in the structure. Crystallographic analysis of DB1880 bound to an AATT site shows how it fits to the minor groove with big piperidinyl substituents.