Short Antimicrobial Lipo-α/γ-AA Hybrid Peptides
Yaqiong Li, Christina Smith, Haifan Wu, Peng Teng, Yan Shi, Shruti Padhee, Torey Jones, Anh-My Nguyen, Chuanhai Cao, Hang Yin and Jianfeng Cai
Article first published online: 28 AUG 2014 | DOI: 10.1002/cbic.201402264
Best of both worlds: We developed short lipo-α/γ-AA hybrid peptides that display potent, broad-spectrum activity against medicinally relevant Gram-positive and Gram-negative bacteria. These hybrids are easier to synthesize and more selective than previously developed lipo-γ-AA peptides and therefore have potential for developing a new class of antibiotics to combat drug resistance.