Baceridin, a Cyclic Hexapeptide from an Epiphytic Bacillus Strain, Inhibits the Proteasome
Dr. Jutta Niggemann, Dr. Przemyslaw Bozko, Nicole Bruns, Anne Wodtke, Dr. Marc Timo Gieseler, Kevin Thomas, Dr. Christine Jahns, Dr. Manfred Nimtz, Inge Reupke, Prof. Dr. Thomas Brüser, Prof. Georg Auling, Prof. Dr. Nisar Malek and Prof. Dr. Markus Kalesse
Article first published online: 1 APR 2014 | DOI: 10.1002/cbic.201300778
Go your own way: The cyclic hexapeptide baceridin was isolated from the culture medium of a plant-associated Bacillus strain. The configuration could be assigned by chemical degradation and total synthesis. In the course of biological validations baceridin was identified as a proteasome inhibitor that inhibits cell-cycle progression and induces apoptosis in tumor cells by a p53-independent pathway.