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The cover picture shows the NMR spectroscopy solution structures of duplex RNA, pyranosyl-RNA, and the “nucleo-δ-peptide” analogue NDP. Storage and transfer of genetic information in biological systems depends on the reversible duplex formation stabilized by complementary Watson–Crick base pairing and the ability to assemble monomers in specific sequences with high fidelity. The design of alternative self-pairing polymers helps in the understanding of the determinants of nucleic acid structure itself. Further details about the comparison of the structures shown can be found in the article by Schwalbe and co-workers on p. 93 ff.