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Cover Picture: ChemBioChem 4/2002
The cover picture shows a representation of a ratchet model where the integration of multiple signals by the transmitter kinase VirA is achieved by xenognostic signal induced movement between three accessible homodimeric coiled-coil interfaces. It is this interface registry that activates the kinase domain, initiating lateral gene transfer from Agrobacterium tumefaciens to its eukaryotic host. Further details can be found in the article by Lynn and co-workers on p. 311 ff.