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Cover Picture: ChemBioChem 7/2002
The cover picture shows the petrosaspongiolide M molecule (PM), a marine natural product with potent anti-inflammatory activity, docked into the active site of phospholipase A2 (PLA2). The pharmacophoric γ-hydroxybutenolide ring of PM lies in close proximity to the N terminus of the enzyme. Further details can be found in the article by Gomez Paloma and co-workers on p 664 ff.