Cover image for Vol. 18 Issue 10

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Cover Picture: A Powerful Combinatorial Screen to Identify High-Affinity Terbium(iii)-Binding Peptides (ChemBioChem 4/2003)

4_04/2003The cover picture shows the chemistry and biology used to develop a new protein labeling strategy based on lanthanide-binding peptides. Focused peptide libraries are screened to identify oligopeptide motifs of dual function: the peptides bind TbIII with remarkably high affinity and promote intense TbIII luminescence. The peptide sequences are then genetically encoded to create recombinant fusion proteins that possess a site-specific and minimally invasive fluorophore. Further information can be found in the two articles by Imperiali and co-workers on pp. 265–271 and pp. 272–276.

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