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Cover Picture: Consensus Design of Repeat Proteins (ChemBioChem 2/2004)
The cover picture shows an illustration of consensus design, a powerful protein-engineering method that is based on sequence alignments of homologous proteins. An alignment of ankyrin repeats is shown in the sequence plane, and a consensus-designed ankyrin repeat protein based on this alignment is shown in ribbon representation hovering over the plane. See more about the consensus design of repeat proteins and its use in repeat-protein library construction in the article by Plückthun et al. on p. 183 ff. Such libraries promise to be excellent sources of a novel type of specific binding molecules. The help of Christian Zahnd in preparing this picture is gratefully acknowledged.