Cover image for Vol. 18 Issue 14

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

Cover Picture: 1,2,3-Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV-1 Protease Inhibitors (ChemBioChem 7/2005)

6_07/2005The cover picture shows a close up of the substrate-bindng site of HIV protease (shown as a blue ribbon), with the NC-P1 substrate (shown as a thin black backbone and transparent solvent-excluded surface) and the backbone of the click chemistry-based triazole inhibitor (shown as ball and stick, atoms colored). The structural water (red sphere) hydrogen bonds to a triazole nitrogen of the inhibitor and to the substrate peptide backbone. For further details, see the article by C.-H. Wong, A. Wlodawer, D. S. Goodsell et al. on p. 1167 ff.

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