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Cover Picture: Regioselective Carbon–Carbon Bond Formation in Proteins with Palladium Catalysis; New Protein Chemistry by Organometallic Chemistry (ChemBioChem 1/2006)
The cover picture shows how the carbon–carbon bond formation in a protein has been achieved by a combined approach of organic synthesis and genetic engineering. Palladium-catalyzed reactions have been used in the synthesis of a wide variety of organic molecules. Among them, the Mizoroki–Heck reaction allows alkenylation of an aryl iodide to be performed under mild conditions. In the article by S. Fukuzawa, K. Tachibana, S. Yokoyama, et al. on p. 134 ff, it is demonstrated how fragile biomolecules like proteins can be substrates for palladium-catalyzed reactions.