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Cover Picture: Identification by 19F NMR of Traditional Chinese Medicinal Plants Possessing Prolyl Oligopeptidase Inhibitory Activity (ChemBioChem 5/2006)
The cover picture shows several traditional Chinese medicinal plants used to in the search for new prolyl oligopeptidase inhibitors. From top to the bottom and from left to right they are: Medulla junci, Folium mori, Radix polygalae, Herba lophatheri, Radix et Rhizoma rhei, Radix scrophulariae, Caulis polygoni, Lapis chloriti and Os draconis. The fluorine spectrum is from a new prolyl oligopeptidase activity assay based on the combined use of 19F NMR and a fluorinated prolyl oligopeptidase substrate. This assay is used to screen the plant extracts for prolyl oligopeptidase inhibitory properties, and several extracts have been identified as potent inhibitors of this peptidase. Further details can be found in the article by E. Giralt and co-workers on p. 827 ff.