ChemBioChem

Cover image for Vol. 17 Issue 18

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

10_15/2009Cover Picture: Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12-Aza-Epothilone (Azathilone) (ChemBioChem 15/2009)

The cover picture shows cells with a green fluorescent microtubule network after treatment with the fluorescent epothilone analogue NBD-azathilone. Docking studies indicate that the NBD moiety of the tubulin-bound analogue is located in a hydrophobic pocket that is not utilized by natural epothilones and directly contributes to tubulin binding. For further information on elucidating the binding and cellular effects of this analogue, see the article by K. H. Altmann et al. on p. 2513 ff.

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