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Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009)
The inside cover picture shows the active site of pantothenate synthetase templating a dynamic combinatorial library of disulfides. Library members were formed dynamically between anchor ligand 5'-deoxy-5'-thioadenosine and thiol fragments to probe interactions in adjacent pockets. The best binder was identified by HPLC analysis and confirmed by X-ray crystallography. For more information, see the paper by A. Ciulli, C. Abell et al. on p. 2772 ff.