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Inside Cover: Leveraging a Small-Molecule Modification to Enable the Photoactivation of Rho GTPases (ChemBioChem 18/2009)
The inside cover picture shows the Rho GTPase Cdc42 modified with a photolabile small molecule that recruits the protein HaloTag. This two-part modification system prevents Cdc42 from binding and being activated by nucleotide. Irradiation with longwave UV light releases the HaloTag-bound photoligand and restores the GTP-dependent activity of Cdc42 as demonstrated in the paper by K. R. Harwood and S. C. Miller on p. 2855 ff.