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Cover Picture: Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling (ChemBioChem 2/2010)
The cover picture shows the crystal structure of the human monoacylglycerol lipase (MAGL). This enzyme constitutes the most relevant pathway that terminates the action of 2-arachidonoylglycerol, which is one of the main representatives of a family of signaling lipids known as “endocannabinoids”. These messengers act by activating the CB1 and CB2 cannabinoid receptors, the molecular targets of the psychoactive constituent of Cannabis sativa, D9-THC, thereby modulating synaptic transmission in the brain. For more information, see the paper by D. M. Lambert et al. on p. 218 ff.