ChemBioChem

Cover image for Vol. 16 Issue 6

Editor: Peter Gölitz; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

11_03/2010Cover Picture: Glyco-Scan: Varying Glycosylation in the Sequence of the Peptide Hormone PYY3-36 and Its Effect on Receptor Selectivity (ChemBioChem 3/2010)

The cover picture shows the concept of a glyco-scan of a peptide, as demonstrated for the hormone PYY3-36. PYY3-36 has been implicated in food intake regulation, and novel peptide analogues with high Y2-receptor-subtype selectivity and potency have potential as drugs for the treatment of obesity. It has been hypothesized that PYY3-36 associates with the plasma membrane prior to receptor activation so that the amphipathic α-helix of PYY3-36 can guide the C-terminal pentapeptide into the correct conformation for receptor activation. On p. 366 ff., N. Vrang, K. J. Jensen et al. show how the introduction and systematic variation of glycosylation in the peptide PYY3-36 can be used to „scan“ a peptide analogous to an Ala scan. This demonstrated that glycosylation of PYY3-36 is well tolerated in several positions and even improves the Y-receptor selectivity. The glyco-scan concept, as systematically demonstrated here, has the potential for wide applicability. (Cover design Jesper Cairo Westergaard.)

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