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Inside Cover: A Potential Antitumor Drug (Arginine Deiminase) Reengineered for Efficient Operation under Physiological Conditions (ChemBioChem 16/2010)
The inside cover picture shows the tetrameric model (based on PaADI, PDB ID: 2A9G) of the K5T/D38H/D44E/A128T/E296K/H404R variant of the potential antitumor protein drug PpADI. The highlighted substitutions significantly improve kcat (64.7 times higher) and/or reduce the S0.5 value (62 % that of wild-type PpADI). For further information, see the paper by U. Schwaneberg, et al. on p. 2294 ff.