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Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010)
The inside cover picture shows a covalent inhibitor bound to the drug resistance mutant T790M of the epidermal growth factor receptor kinase (EFGR). The inhibitor interacts with the hinge region of the kinase domain, and its electrophile modifies the side chain thiol of a cysteine residue of EGFR. For further details, see the paper by D. Rauh et al. on p. 2557 ff.