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Inside Cover: The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution (ChemBioChem 1/2011)
The inside cover picture shows “Salinispora pacifica”. In their Communication on p. 61 ff., B. S. Moore et al. reveal how genome mining of this marine bacterium led to the discovery of salinosporamide K, a new proteasome inhibitor of the salinosporamide structural family. Bioinformatic analysis of its biosynthetic gene cluster revealed a loss of gene function relative to the chlorinated salinosporamide A gene locus of Salinispora tropica that accounts for their structural differences and suggests pathway evolution.