ChemBioChem

Cover image for Vol. 17 Issue 14

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

12_01i/2011Inside Cover: The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution (ChemBioChem 1/2011)

The inside cover picture showsSalinispora pacifica”. In their Communication on p. 61 ff., B. S. Moore et al. reveal how genome mining of this marine bacterium led to the discovery of salinosporamide K, a new proteasome inhibitor of the salinosporamide structural family. Bioinformatic analysis of its biosynthetic gene cluster revealed a loss of gene function relative to the chlorinated salinosporamide A gene locus of Salinispora tropica that accounts for their structural differences and suggests pathway evolution.

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