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Inside Cover: Different Active-Site Loop Orientation in Serine Hydrolases versus Acyltransferases (ChemBioChem 5/2011)
The inside cover picture shows a hydrolysis on–off gate. The oxyanion loop conformation near the active site distinguishes a hydrolase (Pseudomonas fluorescens esterase) from an acyltransferase (mycolyltransferase from Mycobacterium tuberculosis). For further details, see the paper by R. J. Kazlauskas et al. on p. 768 ff.