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Inside Cover: Inhibition of Influenza Virus Activity by Multivalent Glycoarchitectures with Matched Sizes (ChemBioChem 6/2011)
The inside cover picture shows polyglycerol-based nanogels (~50 nm, blue) functionalized with sialic acid residues (orange). These glycocalyx mimetics are excellent inhibitors of influenza virus (green) binding and fusion. The optimal multivalent inhibitor reduces viral activity by up to 80 %; this emphasizes the importance of particle dimension and polyvalency for efficient competition with the cell surface (yellow). For further information, see the paper by R. Haag et al. on p. 887 ff.