ChemBioChem

Cover image for Vol. 18 Issue 10

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

12_15i/2011Inside Cover: Mutant Malonyl-CoA Synthetases with Altered Specificity for Polyketide Synthase Extender Unit Generation (ChemBioChem 15/2011)

The inside cover picture shows the shift in substrate specificity of malonyl-CoA synthetase towards non-native malonate analogues afforded by active-site saturation mutagenesis followed by colorimetric screening for improved activity. Mutant synthetases could provide extender units for probing the activity of polyketide synthases. For further details, see the paper by G. J. Williams and I. Koryakina on p. 2289 ff.

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