Cover image for Vol. 18 Issue 24

Editor: Ruben Ragg; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

12_16/2011Cover Picture: A Synthetic Mirror Image of Kalata B1 Reveals that Cyclotide Activity Is Independent of a Protein Receptor (ChemBioChem 16/2011)

The cover picture shows mirror image forms of the cyclotide kalata B1, a 29-residue peptide with a cyclic backbone and a cystine knot. The native peptide is isolated from the African plant Oldenlandia affinis, which is used in an indigenous medicinal tea to accelerate labour, but has a range of other activities, including anti-HIV activity. The synthetic mirror image form, made from d-amino acids, was assembled by solid-phase peptide synthesis and used to demonstrate that membrane binding, rather than a chiral receptor, is implicated in cyclotide bioactivity. For more information, see the paper by D. J. Craik et al. on p. 2456 ff. (Cover art designed by David Wilson, University of Queensland.)

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