ChemBioChem

Cover image for Vol. 19 Issue 1

Editor: Ruben Ragg; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

12_17/2011Cover Picture: Long-Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages (ChemBioChem 17/2011)

The cover picture shows the differential activation of macrophages by synthetic trehalose diesters of various chain lengths. Small-chain analogues (C4–C10) show no activity and medium-length analogues (C18) show moderate activity; however, longer derivatives (C20–C26) lead to optimal activation of macrophages, as evidenced by NO production and the generation of cytokines such as IL-6 and IL-1β. For more details, see the paper by M. S. M. Timmer, B. L. Stocker et al. on p. 2572 ff.

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