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Inside Cover: The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2 (ChemBioChem 17/2011)
The inside cover picture shows the peculiar dual binding of the marine sponge metabolite Cladocoran A to the human secretory PLA2 enzyme, which is responsible for its relevant anti-inflammatory activity. For further details on the PLA2 inhibition mechanism at a molecular level, see the paper by A. Casapullo et al. on p. 2686 ff.