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Inside Cover: Mechanism-Oriented Redesign of an Isomaltulose Synthase to an Isomelezitose Synthase by Site-Directed Mutagenesis (ChemBioChem 1/2012)
The inside cover picture shows the sucrose isomerase from Protaminobacter rubrum. Sequence and structure alignments in combination with mechanism-based docking studies (close-up view) revealed target sites for site-directed mutagenesis, thus enabling the synthesis of the trisaccharide isomelezitose in up to 70 % yield. For more information, see the paper by J. Seibel et al. on p. 149 ff.