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Inside Cover: Generation of RNA Molecules by a Base-Catalysed Click-Like Reaction (ChemBioChem 7/2012)
The inside cover picture shows the spontaneous polymerization of 3',5'-cyclic GMP occurring in water, in formamide, in dimethylformamide, and (in water) in the presence of a Brønsted base such as 1,8-diazabicycloundec-7-ene. The polymerization occurs among stacked monomers, is thermodynamically favoured and selectively yields 3',5'-bonded ribopolymers. For further details see the paper by E. Di Mauro et al. on p. 999 ff.