ChemBioChem

Cover image for Vol. 16 Issue 2

Editor: Peter Gölitz; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

13_10i/2012Inside Cover: Peptide Bicycles that Inhibit the Grb2 SH2 Domain (ChemBioChem 10/2012)

The inside cover picture shows a new strategy for designing constrained peptides that involves careful introduction of side-chain-to-side chain crosslinks within a head-to-tail peptide macrocycle. For details of how it was used to produce peptide bicycles that target Grb2 with higher potency, better selectivity, and greater resistance to degradation, see the communication by J. A. Kritzer et al. on p. 1490 ff.

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