Cover image for Vol. 17 Issue 3

Editor: Meghan Campbell; Editorial Board Chairs: Thomas Carell, Donald Hilvert, Barbara Imperiali

Online ISSN: 1439-7633

Associated Title(s): ChemCatChem, ChemMedChem, ChemPhysChem, ChemSusChem

13_14/2012Cover Picture: Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition (ChemBioChem 14/2012)

The cover picture shows a living eukaryotic cell, wherein the nuclear DNA–histone complexes of chromatin undergo dynamic conformational changes that are regulated by HATs (reversible lysine acetylation) and HDACs (deacetylation). This can be controlled experimentally by cell-permeable small molecules, such as the p300/CBP HAT inhibitor, C107, or the classical HDAC inhibitor, TSA. On p. 2113 ff., P. A. Cole et al. explain how, with the use of a FRET-based reporter of histone acetylation, the real-time effects of these pharmacological manipulations can be visualized and quantified as a change in ratio of yellow and cyan fluorescence. Inside Cover For more details, see the Full Paper by H. Schwalbe et al. n p. 2100 ff. Back Cover For more details, see the Communication by Y. Watanabe et al. on p. 2045

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