Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
November 14, 2014
VIP: Exploring the Free Energy and Conformational Landscape of tRNA at High Temperature and Pressure
Caroline Schuabb, Melanie Berghaus, Christopher Rosin and Prof. Dr. Roland Winter
RNA under pressure! Exploration of the conformational and free-energy landscape of the 76-residue yeast phenylalanine transfer RNA (tRNAPhe; see figure) reveals that RNA unfolding differs not only from protein unfolding but also from DNA melting. Compared with the pronounced temperature effect, pressure-dependent changes in the secondary structure of tRNAPhe are small, however, even up to the 1000 MPa range.
Recently Published Articles
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Herme G. Baldovi, Ferran Albarracin, Dr. Pedro Atienzar, Dr. Belen Ferrer, Prof. Mercedes Alvaro and Prof. Hermenegildo Garcia
Article first published online: 21 NOV 2014 | DOI: 10.1002/cphc.201402660
A life cut short: A combined study of the photocurrent from Au–TiO2 films compared with H2 generation from water/methanol mixtures is presented. Gold seems to introduce charge separation with visible light, but the lifetime of charge separation on the relevant microsecond timescale is too short for interparticle charge migration.
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Seth M. McAfee, Dr. Jessica M. Topple, Abby-Jo Payne, Jon-Paul Sun, Dr. Ian G. Hill and Dr. Gregory C. Welch
Article first published online: 21 NOV 2014 | DOI: 10.1002/cphc.201402662
A blueprint for the sustainable synthesis of electron-accepting small molecules as fullerene alternatives in organic photovoltaics is presented.
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Malcolm E. Tessensohn, Melvyn Lee, Prof. Dr. Hajime Hirao and Prof. Dr. Richard D. Webster
Article first published online: 21 NOV 2014 | DOI: 10.1002/cphc.201402693
On the strength of it: The electrochemistry of quinones in aprotic organic solvents is used to measure the hydrogen-bonding strengths of alcohols. The values of the potential separation between two one-electron reduction processes can be easily obtained through the voltammetry of a quinone and can be used to distinguish between primary, secondary, and tertiary alcohols, as well as diols.
- Modeling of Structural, Energetic, and Dynamic Properties of Few-Atom Silver Clusters Embedded in Polynucleotide Strands by Using Molecular Dynamics
Dr. Nicolas Staelens, Dr. Laurence Leherte, Prof. Benoît Champagne and Prof. Daniel P. Vercauteren
Article first published online: 20 NOV 2014 | DOI: 10.1002/cphc.201402632
Stabilizing silver: The structural, energetic, and dynamic properties of fluorescent systems composed of silver clusters stabilized by polynucleotide strands (see figure) were studied by introducing classical interaction potentials relative to silver into the AMBER force field. Molecular dynamics simulations and conformational analyses were used to analyze the interactions between the nucleic oligomers and the silver clusters and the flexibility of the supramolecular assemblies.
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Mingjun Xuan, Xiankun Lin, Jingxin Shao, Dr. Luru Dai and Prof. Qiang He
Article first published online: 20 NOV 2014 | DOI: 10.1002/cphc.201402795
Going through the motions: The integration of self-propelled Janus silica micromotors and polyelectrolyte multilayer capsules into a lab-on-chip device provides a new method for the separation and analysis of different charged organics in water.