ChemPhysChem

Cover image for Vol. 15 Issue 17

Editor: Greta Heydenrych; Editorial Board Chairs: Christian Amatore, Michael Grätzel, Michel Orrit

Online ISSN: 1439-7641

Associated Title(s): Advanced Materials, ChemBioChem, ChemCatChem, ChemElectroChem, ChemSusChem, Small

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November 14, 2014

VIP: Exploring the Free Energy and Conformational Landscape of tRNA at High Temperature and Pressure

Caroline Schuabb, Melanie Berghaus, Christopher Rosin and Prof. Dr. Roland Winter

Exploring the Free Energy and Conformational Landscape of tRNA at High Temperature and PressureRNA under pressure! Exploration of the conformational and free-energy landscape of the 76-residue yeast phenylalanine transfer RNA (tRNAPhe; see figure) reveals that RNA unfolding differs not only from protein unfolding but also from DNA melting. Compared with the pronounced temperature effect, pressure-dependent changes in the secondary structure of tRNAPhe are small, however, even up to the 1000 MPa range.

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