Investigation of DOTA–Metal Chelation Effects on the Chemical Shift of 129Xe
Keunhong Jeong, Clancy C. Slack, Dr. Christophoros C. Vassiliou, Phuong Dao, Muller D. Gomes, Dr. Daniel J. Kennedy, Ashley E. Truxal, Dr. Lindsay J. Sperling, Prof. Dr. Matthew B. Francis, Prof. Dr. David E. Wemmer and Prof. Dr. Alexander Pines
Article first published online: 7 OCT 2015 | DOI: 10.1002/cphc.201500806
The Xe factor: A cryptophane–DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) metal-ion sensor showed distinct 129Xe chemical shifts for various metal ions that were dependent on the chirality. The chemical shifts of hyperpolarized xenon detected with this sensor provide a firm basis for detecting and quantifying many important metal ions and further our understanding of xenon-based metal-ion detection.