Protein Science

Cover image for Vol. 25 Issue 6

Edited By: Brian W. Matthews

Impact Factor: 2.854

ISI Journal Citation Reports © Ranking: 2014: 136/290 (Biochemistry & Molecular Biology)

Online ISSN: 1469-896X

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  • Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly

    Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly

    Ribbon representation of M. jannaschii FlaH. The protein has typical RecA-like fold with Walker A and Walker B motifs located between β3 and α2, and on β6, respectively. Sulfate ions bound to P-loop (Walker A) are shown as ball-and-stick models. An interactive view is available in the electronic version of the article.

  • Disorder transitions and conformational diversity cooperatively modulate biological function in proteins

    Disorder transitions and conformational diversity cooperatively modulate biological function in proteins

    Biological examples of order-disorder transitions between protein conformations. The region suffering order-disorder transition is coloured in red. (a) Protein DivK conformations present an order-disorder transition between apo (PDB code: 1M5T_A - color blue) and holo (PDB code: 1MB0_A - color cyan) forms. These structures present a C-apha RMSD of 0.345 A. (b) Enzyme dihydropteroate synthase (DHPS) shows an order-desorden transition in the conformers PDB code: 3TYZ_B (color blue) and 3TZN (color cyan). These structures present a C-alpha RMSD of 0.548 A. (c) Conformers of human Transthyretin (TTR), (c1) Apo form (PDB code: 1TTA_B - color blue) and holo form (PDB code: 3D2T_B - color cyan) in complex with diflunisal. (c2) Apo conformation of TTR (PDB code: 1TTA_B - color blue) and apo form (PDB code: 3CBR_B - color cyan) at pH 3.5.

  • Resurfaced cell-penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery

    Resurfaced cell‐penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery

    (A) A previously reported nanobody that binds Green Fluorescent Protein (GFP), PDB: 3OGO. This nanobody is referred to as NB1 in this work. Complementarity-determining region (CDR) loops are highlighted in purple. (B) Residues on NB1 that were mutated to either arginine or lysine to generate the resurfaced polycationic nanobody (pcNB1) are highlighted with blue spheres.

  • Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract

    Aggregation of Trp > Glu point mutants of human gamma‐D crystallin provides a model for hereditary or UV‐induced cataract

    A backbone ribbon representation of the HγD crystal structure (PDB ID 1HK0) (32) showing the four conserved buried Trp residues.

  • The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex

    The impact of crystallization conditions on structure‐based drug design: A case study on the methylene blue/acetylcholinesterase complex

    Interactions of MB and DECA with the indole moiety of Trp84 in their complexes with TcAChE in crystals obtained using AS as the precipitant. The indole of Trp84 is displayed in space-filling mode, with carbon atoms colored yellow. MB and DECA are depicted as stick models, with their carbon atoms in cyan and magenta, respectively. Whereas the proximal quaternary group of MB in MB-AS/TcAChE interacts with the five-membered ring of the indole, in the DECA-AS/TcAChE structure, the DECA extends further, such that its proximal quaternary group interacts with the indole's six-membered ring.

  • From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides

    From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides

    Main molecular mechanism of actions deployed by the antitumor peptides presented in this review.

  • Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly
  • Disorder transitions and conformational diversity cooperatively modulate biological function in proteins
  • Resurfaced cell‐penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery
  • Aggregation of Trp > Glu point mutants of human gamma‐D crystallin provides a model for hereditary or UV‐induced cataract
  • The impact of crystallization conditions on structure‐based drug design: A case study on the methylene blue/acetylcholinesterase complex
  • From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides

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Special Issue in Honor of Ron Levy

Protein Science Awards

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2016 Best Paper Award Winners
We are pleased to announce the winners of the 2016 Protein Science Best Paper Award:

Tracy Clinton
Air Force Biochemist

Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets
Tracy R. Clinton, Matthew T. Weinstock, Michael T. Jacobsen, Nicolas Szabo-Fresnais, Maya J. Pandya, Frank G. Whitby, Andrew S. Herbert, Laura I. Prugar, Rena McKinnon, Christopher P. Hill, Brett D. Welch, John M. Dye, Debra M. Eckert and Michael S. Kay
Protein Sci. 24:446-463, 2015.

Michael Thompson
Postdoctoral Fellow
Department of Bioengineering and Therapeutic Sciences at University of California, San Francisco

An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein
Michael C. Thompson, Duilio Cascio, David J. Leibly and Todd O. Yeates
Protein Sci. 24:956-975, 2015.

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2016 Young Investigator Award Winner

The Protein Science Young Investigator Award recognizes a scientist generally within the first 8 years of an independent career who has made an important contribution to the study of proteins. The 2016 winner is Dr. Benjamin Garcia (University of Pennsylvania Perelman School of Medicine).

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More information on our awards can be found here.

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