Protein Science

Cover image for Vol. 26 Issue 10

Edited By: Brian W. Matthews

Impact Factor: 2.523

ISI Journal Citation Reports © Ranking: 2016: 158/286 (Biochemistry & Molecular Biology)

Online ISSN: 1469-896X

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  • Structure of the WD40-domain of human ATG16L1

    Structure of the WD40‐domain of human ATG16L1

    Structure of the ATG16L1 WDD. (A) Cartoon representation of the structure of ATG16L1 WDD in two orientations. The seven-bladed propeller is shown in rainbow color (N terminus in blue, C terminus in red). Individual strands (A–D) and blades (1–7) are labeled. (B) Sequence of the ATG16L1 WDD (corresponding to the wild-type human ATG16L1 sequence) with the assignment of secondary structure boundaries

  • Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity

    Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity

    Alignment of GRN-3 structure (green) predicted using I-TASSER with that of NMR structure of GRN-4 (blue) using PyMol. The rms deviation is 1.02 Å.

  • Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1

    Crystal structural characterization reveals novel oligomeric interactions of human voltage‐dependent anion channel 1

    Map of electron density around a single spermidine molecule. The electron density map (blue; 2Fo–Fc map contoured at 1.0 σ) shows that the spermidine molecule interacts with the structure of hVDAC1 with crystals in space group C222. The α-helix and β-sheets are depicted in red and light-blue, respectively

  • SARS-unique fold in the Rousettus bat coronavirus HKU9

    SARS‐unique fold in the Rousettus bat coronavirus HKU9

    Overlay of HKU9-C (green) and SARS-C (cyan) backbone with secondary structures shown. Sidechains from Arg 588-Asp 589-Trp 590, and Lys 609-Arg 610-Gly 611 (HKU9 C) and Arg 670-Asp 671-Trp 672, and Lys 687-Arg 688-Gly 689 (SARS C) are shown with the corresponding one-letter amino acid code

  • Can the propensity of protein crystallization be increased by using systematic screening with metals?

    Can the propensity of protein crystallization be increased by using systematic screening with metals?

    Crystals of the putative rRNA methyltransferase from Sinorhizobium meliloti, (A) in the condition 5 mM CoCl2, 5 mM NiCl2, 5 mM CdCl2, 5 mM MgCl2, 0.1 M HEPES pH 7.5, 12% wt/vol PEG 3,350 (B) in the condition 5 mM NiCl2, 5 mM CdCl2, 5 mM MgCl2, 0.1 M HEPES pH 7.5, 9% wt/vol PEG 3,350 (C) in the condition 5 mM CoCl2, 0.1 M HEPES pH 7.5, 9% wt/vol PEG 3,350 and (D) in the condition 5 mM NiCl2, 0.1 M HEPES pH 7.5, 9% wt/vol PEG 3,350. In (C) and (D) the protein was incubated with MgCl2.The best crystals so far seem to be in the condition with 5 mM CoCl2, 0.1 M HEPES pH 7.5, 9% wt/vol PEG 3,350 with MgCl2 incubated protein.

  • Effects of aligned α-helix peptide dipoles on experimental electrostatic potentials

    Effects of aligned α‐helix peptide dipoles on experimental electrostatic potentials

    DFT-derived ESP (A,C) and ED (B,D) functions are truncated to 2.0-Å resolution (A,B) and 2.5-Å resolution (C,D) contoured at +5σ (cyan, top), +4σ (silver), +3σ (yellow), +2σ (salmon), and +1σ (green, bottom).

  • Structure of the WD40‐domain of human ATG16L1
  • Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity
  • Crystal structural characterization reveals novel oligomeric interactions of human voltage‐dependent anion channel 1
  • SARS‐unique fold in the Rousettus bat coronavirus HKU9
  • Can the propensity of protein crystallization be increased by using systematic screening with metals?
  • Effects of aligned α‐helix peptide dipoles on experimental electrostatic potentials

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Author Suzanne Scarlata on her recently published Protein Science paper entitled "Regulation of the Activity of the Promoter of RNA-induced Silencing, C3PO." Read the paper here

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Protein Science Awards

2017 Best Paper Award

2017 Best Paper Award Winners
We are pleased to announce the winners of the 2017 Protein Science Best Paper Award:

Charlotte Miton
Postdoctoral Research Fellow
Michael Smith Laboratories at University of British Columbia

How mutational epistasis impairs predictability in protein evolution and design
Charlotte M. Miton and Nobuhiko Tokuriki
Protein Sci. 25:1260-1272, 2016.

Zach Schaefer
Graduate Student
Department of Biochemistry and Molecular Biology at University of Chicago

A polar ring endows improved specificity to an antibody fragment
Zachary P. Schaefer, Lucas J. Bailey and Anthony A. Kossiakoff
Protein Sci. 25:1290-1298, 2016.

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2017 Young Investigator Award Winner

The Protein Science Young Investigator Award recognizes a scientist generally within the first 8 years of an independent career who has made an important contribution to the study of proteins. The 2017 winner is Dr. David Pagliarini (University of Wisconsin, Madison).

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More information on our awards can be found here.

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