Journal of Pharmaceutical Sciences

Cover image for Vol. 104 Issue 12

Edited By: Dr. Ronald T. Borchardt

Impact Factor: 2.59

ISI Journal Citation Reports © Ranking: 2014: 26/59 (Chemistry Medicinal); 49/157 (Chemistry Multidisciplinary); 109/255 (Pharmacology & Pharmacy)

Online ISSN: 1520-6017

Special Virtual Issue - Editors' Picks (OCT 2013 - DEC 2013)

“This is a special virtual issue comprised of the Editors’ choices of the most original and most significant scientific findings published in the preceding three issues (October 2013-December 2013) of JPharmSci®.” These papers will be freely available until March 31st 2014.

This quarter we feature Tetsuya Terasaki’s comments for the paper he chose:

" Pharmacokinetic study of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute in an anticancer drug-induced thrombocytopenia rat model " pages 3852-3859, DOI: 10.1002/jps.23692

For the treatment of thrombocytopenia, platelets are transfused to the patients. As the shelf life of platelets is very short (~ 5 days), significant efforts have been made to develop clinically applicable "artificial platelets" in the past 50 years. Recently, Japanese researchers have developed adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide [H12-(ADP)-liposome] as a new candidate of "artificial platelets". In this paper, the authors investigated pharmacokinetics of H12-(ADP)-liposome in busulphan-induced thrombocytopenic rats and normal rats. This work provides important findings for the understanding of PK/PD of H12-(ADP)-liposome in the patients.

Additional selections by the Editorial Board include:

Effects of temperature and osmolytes on competing degradation routes for an IgG1 antibody
Christopher J. Roberts, Douglas P. Nesta1, Nayoung Kim

An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters
Patrick Poulin, Donna M. Dambach, Dylan H. Hartley, Kevin Ford, Frank-Peter Theil, Eric Harstad, Jason Halladay, Edna Choo, Jason Boggs, Bianca M. Liederer, Brian Dean, Dolores Diaz

In Vitro Tools for Evaluating Novel Dosage Forms of Poorly Soluble, Weakly Basic Drugs: Case Example Ketoconazole
Thomas Taupitz, Jennifer B. Dressman and Sandra Klein

Pharmaceutical Development and Regulatory Considerations for Nanoparticles and Nanoparticulate Drug Delivery Systems
Ajit S. Narang, Rong-Kun Chang, Munir A. Hussain

Chemometric Evaluation of Near Infrared, Fourier Transform Infrared, and Raman Spectroscopic Models for the Prediction of Nimodipine Polymorphs
Akhtar Siddiqui, Ziyaur Rahman, Vilayat A. Sayeed, Mansoor A. Khan

Development of a Human Antibody Tolerant Mouse Model to Assess the Immunogenicity Risk Due to Aggregated Biotherapeutics
Vivian Bi1, Vibha Jawa, Marisa K. Joubert, Arunan Kaliyaperumal, Catherine Eakin, Karen Richmond, Oscar Pan, Jilin Sun, Martha Hokom, Theresa J. Goletz, Jette Wypych, Lei Zhou, Bruce A. Kerwin, Linda O. Narhi, Taruna Arora

The Impact of Hot Melt Extrusion and Spray Drying on Mechanical Properties and Tableting Indices of Materials Used in Pharmaceutical Development
Raman Iyer, Shridhar Hegde, Yu-E Zhang, James Dinunzio, Dharmendra Singhal, A. Malick, Gregory Amidon

Preparation of Andrographolide-Loaded Solid Lipid Nanoparticles and Their In Vitro and In Vivo Evaluations: Characteristics, Release, Absorption, Transports, Pharmacokinetics, and Antihyperlipidemic Activity
Tao Yang, Huan-Huan Sheng, Nian-Ping Feng, Hai Wei, Zheng-Tao Wang, Chang-Hong Wang