BioEssays

Cover image for Vol. 40 Issue 2

Editor: Andrew Moore

Online ISSN: 1521-1878

Recently Published Issues

See all

Highlights from the current issue

Volume 40, Issue 2, February 2018


Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication

Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication

Matthias J. Scherr, Barbara Safaric, Karl E. Duderstadt*

Recent single-molecule studies have revealed that replisome function is dominated by stochastic sampling of multiple molecular pathways. In the context of these new findings, we re-examine the foundational assumptions and seminal experiments that have guided our understanding of replication mechanism and reconcile several long-debated coordination models.

BioEssays2018, 40, No. 2, 0 [Insights & Perspectives]

When MicroRNAs Meet RNA Editing in Cancer: A Nucleotide Change Can Make a Difference

When MicroRNAs Meet RNA Editing in Cancer: A Nucleotide Change Can Make a Difference

Yumeng Wang, Han Liang*

RNA editing is introduced by ADAR or APOBEC enzymes, leading to specific nucleotide changes, respectively. The interplays between RNA editing and miRNAs may play important roles in cancer. This graphical abstract shows four major mechanisms through which miRNAs interact with RNA editing to confer a functional impact on tumor development.

BioEssays2018, 40, No. 2, 0 [Prospects & Overviews]

Analyzing Horizontal Transfer of Transposable Elements on a Large Scale: Challenges and Prospects

Analyzing Horizontal Transfer of Transposable Elements on a Large Scale: Challenges and Prospects

Jean Peccoud*, Richard Cordaux, Clément Gilbert

With the large amount of genomic resources now available, horizontal transfer of transposable elements can be studied as an evolutionary process, rather than as isolated cases. We discuss some of the difficulties encountered in detecting and counting such transfers and propose guidelines and directions for future research in this area.

BioEssays2018, 40, No. 2, 0 [Prospects & Overviews]

SEARCH

SEARCH BY CITATION