Cover image for Vol. 39 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrew Moore

Online ISSN: 1521-1878


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  1. Prospects & Overviews

    1. Recently in press

      Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before : ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps

      Liying Corinne Lee, Michele Q. L. Goh and Edward H. Koo

      Version of Record online: 21 JUL 2017 | DOI: 10.1002/bies.201700062

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      APP transcription is differentially modulated by apoE and its isoforms: how does this novel mechanism fit with the existing hypotheses?

    2. Review essays

      You have full text access to this OnlineOpen article
      ZC3H12A/MCPIP1/Regnase-1-related endonucleases: An evolutionary perspective on molecular mechanisms and biological functions

      Cornelia Habacher and Rafal Ciosk

      Version of Record online: 18 JUL 2017 | DOI: 10.1002/bies.201700051

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      Regnase-1-related RNases have evolutionary conserved roles connected to cellular defense, targeting exogenous and endogenous pathogenic agents.

    3. Precarious maintenance of simple DNA repeats in eukaryotes

      Alexander J. Neil, Jane C. Kim and Sergei M. Mirkin

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/bies.201700077

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      Break-induced replication (BIR) and template switching (TS) are conserved mechanisms of replication fork restart. They do not cause microsatellite instability in prokaryotes, but promote repeat expansion in eukaryotes. We suggest that TS and BIR persisted in eukaryotes despite their mutagenic potential because they help maintain long repetitive telomeres and centromeres.

  2. Insights & Perspectives

    1. Hypotheses

      You have full text access to this OnlineOpen article
      Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis

      Arthur L. Beaudet

      Version of Record online: 13 JUL 2017 | DOI: 10.1002/bies.201700012

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      The importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis are depicted. Carnitine is absorbed from the intestine to the blood for distribution to liver, kidney, skeletal and cardiac muscle, and across the blood-brain barrier. Carnitine can be synthesized in liver, kidney, and brain.

  3. Thoughts & Opinions

    1. Cause To Reflect

      A tribute to D'Arcy Wentworth Thompson: Elucidation of a developmental principle

      Antony J. Durston and Kongju Zhu

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/bies.201700088

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      We show the vertebrate anterior –posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox-Hox interactions. 4/ ‘Decision points’ involving signalling pathways separate axial domains.

  4. Insights & Perspectives

    1. Hypotheses

      How bacterial cell division might cheat turgor pressure – a unified mechanism of septal division in Gram-positive and Gram-negative bacteria

      Harold P. Erickson

      Version of Record online: 12 JUL 2017 | DOI: 10.1002/bies.201700045

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      A model for E. coli division as modified septation. The septum ingresses from the bottom of a V-shaped constriction, in which new cell wall has split from the forming septum. In Gram positive bacteria the septum continues to the wall of the mother cell, and splits only after it is complete.

  5. Prospects & Overviews

    1. Problems & Paradigms

      Cancer adaptations: Atavism, de novo selection, or something in between?

      Frédéric Thomas, Beata Ujvari, François Renaud and Mark Vincent

      Version of Record online: 10 JUL 2017 | DOI: 10.1002/bies.201700039

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      Evolution theories, atavism initiating from the Precambrian and somatic/convergent evolution can both account for cancer adaptations. While they have distinct implications for therapies, the extent to which both contribute to tumorigenesis remains to be explored. Here we discuss this issue and suggest directions to discriminate between the two competing theories.

    2. Review essays

      Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

      Laura Jadkauskaite, Pierre A. Coulombe, Matthias Schäfer, Albena T. Dinkova-Kostova, Ralf Paus and Iain S. Haslam

      Version of Record online: 7 JUL 2017 | DOI: 10.1002/bies.201700029

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      Accumulation of reactive oxygen species (ROS) is associated with certain hair disorders and exposure to exogenous stressors, being implicated in apoptosis, hair loss, hair miniaturization and melanocytes damage leading to hair greying. NRF2 activators such as sulforaphane (SFN) may protect against the progression of hair disorders associated with elevated ROS.

    3. Problems & Paradigms

      Offspring sex ratio in mammals and the Trivers-Willard hypothesis: In pursuit of unambiguous evidence

      Mathieu Douhard

      Version of Record online: 6 JUL 2017 | DOI: 10.1002/bies.201700043

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      The relationship between offspring sex and maternal condition lies at the heart of one of the most controversial hypotheses in evolutionary biology. This review highlights recent findings on the Trivers-Willard hypothesis with particular emphasis on factors which may mask the relationship of interest or falsely demonstrate it (non-causal association).

    4. Review essays

      Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer

      Di Zhao and Ronald A. DePinho

      Version of Record online: 4 JUL 2017 | DOI: 10.1002/bies.201700076

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      We summarize recent work exploring a novel conceptual approach termed “synthetic essentiality” as a means for targeting tumor suppressor gene deficiencies in cancer. Synthetic essentiality expands the existing concepts for therapeutic strategies, including oncogene addiction, synthetic, and collateral lethality, to provide a framework for the discovery of cancer-specific vulnerabilities.

    5. Recently in press

      Break-induced replication links microsatellite expansion to complex genome rearrangements

      Michael Leffak

      Version of Record online: 16 JUN 2017 | DOI: 10.1002/bies.201700025

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      Break-induced replication (BIR) and genome instability. BIR initiates at sites of microsatellite replication fork collapse (arrowhead). Sister chromatid (black) microsatellite misalignment leads to expansion or contraction. BIR fork collapse allows cycles of error-prone microhomology-mediated BIR (MMBIR), and homology-directed or homeologous recombination to nonhomologous chromosomes (color segments). (Not to scale.)

  6. Insights & Perspectives

    1. Think again

      Cellular compartmentation follows rules: The Schnepf theorem, its consequences and exceptions : A biological membrane separates a plasmatic from a non-plasmatic phase

      Daniel Moog and Uwe G. Maier

      Version of Record online: 16 JUN 2017 | DOI: 10.1002/bies.201700030

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      The compartmentation rule by Eberhard Schnepf (Schnepf theorem) was formulated more than 50 years ago. In its quintessence, it posits that a biological membrane separates a plasmatic form a non-plasmatic phase. The theorem addresses important biological questions including cellular and compartmental evolution as well as endosymbiosis and intracellular parasitism.

    2. Ideas & Speculations

      Long-term evolution of viruses: A Janus-faced balance

      Arshan Nasir, Kyung Mo Kim and Gustavo Caetano-Anollés

      Version of Record online: 16 JUN 2017 | DOI: 10.1002/bies.201700026

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      Viruses evolve with host cells. Their persistence is driven by trade-offs between propagation (lysis), dormancy (latency), and dependency (symbiosis) solutions. While the lytic mode governs viral ecological dynamics, the non-lytic modes of dormancy and dependency may be preferred outcomes in the long-term evolution of viruses.

  7. Prospects & Overviews

    1. Review essays

      Multisensory neural integration of chemical and mechanical signals

      Juan Antonio Sánchez-Alcañiz and Richard Benton

      Version of Record online: 16 JUN 2017 | DOI: 10.1002/bies.201700060

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      Although neuroscientists often study individual sensory modalities independently of all others, animals naturally assimilate diverse types of environmental cues to respond with an appropriate behavior. Recent work has revealed how multisensory integration of chemical and mechanical stimuli can occur through the use of common sensory receptor families, organs and circuitry.


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