The Journal of Gene Medicine

Cover image for Vol. 17 Issue 1-2

Edited By: Shigetaka Asano, Olivier Danos, Kay Davies, Pierre Lehn, Richard Mulligan

Impact Factor: 1.953

ISI Journal Citation Reports © Ranking: 2013: 73/124 (Medicine Research & Experimental); 86/165 (Biotechnology & Applied Microbiology); 112/165 (Genetics & Heredity)

Online ISSN: 1521-2254

Virtual Issues




Non-viral gene delivery

Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation
Cécile Faurie, Matej Rebersek, Muriel Golzio, Masa Kanduser, Jean-Michel Escoffre, Mojca Pavlin, Justin Teissie, Damijan Miklavcic and Marie-Pierre Rols

Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems
Kun Ma, Minxin Hu, Meng Xie, Haijun Shen, Liyan Qiu, Weimin Fan, Hongying Sun, Shuqing Chen, Yi Jin

Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors
Lei Chen, Huayu Tian, Jie Chen, Xuesi Chen, Yubin Huang, Xiabin Jing

The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level
Dominic J. Glover, Denisse L. Leyton, Gregory W. Moseley, Prof David A. Jans

The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery
Reza K. Oskuee, Alexander Philipp, Ali Dehshahri, Ernst Wagner, Mohammad Ramezani

Highly efficient gene transfer system using a laminin-DNA-apatite composite layer
Ayako Oyane, Hideo Tsurushima and Atsuo Ito

Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes
Verena Russ, Thomas Fröhlich, Yunqiu Li, Anna Halama, Manfred Ogris and Ernst Wagner

Effect of chitosan-alginate nanoparticles and ultrasound on the efficiency of gene transfection of human cancer cells
Shu-Jyuan Yang, Szu-Min Chang, Kun-Che Tsai, Wen-Shiang Chen, Feng-Huei Lin and Ming-Jium Shieh

A poly(ethylene) glycolylated peptide for ocular delivery compacts DNA into nanoparticles for gene delivery to post-mitotic tissues in vivo
Sarah Parker Read, Siobhan M. Cashman and Rajendra Kumar-Singh

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Interfering RNA

Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab
Sabrina Höbel, Ivette Koburger, Matthias John, Frank Czubayko, Philipp Hadwiger, Hans-Peter Vornlocher, Achim Aigner

Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction
Min Liang, Masakazu Kamata, Kevin N. Chen, Nonia Pariente, Dong Sung An, Irvin S. Y. Chen

The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery
Reza K. Oskuee, Alexander Philipp, Ali Dehshahri, Ernst Wagner and Mohammad Ramezani

Neuron-specific RNA interference using lentiviral vectors
Troels Tolstrup Nielsen, Ingrid van Marion, Lis Hasholt, Cecilia Lundberg, Nielsen, TT; van Marion, I; Hasholt, L; Lundberg, C

Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs
von Eije, KJ; ter Brake, O; Berkhout, B

Profiling RNA interference (RNAi)-mediated toxicity in neural cultures for effective short interfering RNA design
Read, ML; Mir, S; Spice, R; Seabright, RJ; Suggate, EL; Ahmed, Z; Berry, M; Logan, A

In vitro and in vivo evaluation of small interference RNA-mediated gynaecophoral canal protein silencing in Schistosoma japonicum
Cheng, GF; Fu, ZQ; Lin, JJ; Shi, Y; Zhou, YC; Jin, YX; Cai, YM

Short hairpin RNAs against eotaxin or interleukin-5 decrease airway eosinophilia and hyper-responsiveness in a murine model of asthma
Huang, HY; Lee, CC; Chiang, BL

Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene
Li, F; Mahato, RI

Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs
Kim, EJ; Shim, G; Kim, K; Kwon, IC; Oh, YK; Shim, CK

Intracellular small interfering RNA delivery using genetically engineered double-stranded RNA binding protein domain
Kim, J; Lee, SH; Choe, J; Park, TG

Neuron-specific RNA interference using lentiviral vectors
Troels Tolstrup Nielsen, Ingrid van Marion, Lis Hasholt, Cecilia Lundberg, Nielsen, TT; van Marion, I; Hasholt, L; Lundberg, C

Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides
Rahbek, UL; Howard, KA; Oupicky, D; Manickam, DS; Dong, MD; Nielseni, AF; Hansen, TB; Besenbacher, F; Kjems, J

Exploring gene-deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice
Rauschhuber, C; Xu, H; Salazar, FH; Marion, PL; Ehrhardt, A

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters)
Vanden-Broucke, RE; De Geest, BG; Bonne, S; Vinken, M; Van Haecke, T; Heimberg, H; Wagner, E; Rogiers, V; De Smedt, SC; Demeester, J; Sanders, NN

RNAi-mediated reversible opening of the blood-brain barrier
Campbell, M; Kiang, AS; Kenna, PF; Kerskens, C; Blau, C; O'Dwyer, L; Tivnan, A; Kelly, JA; Brankin, B; Farrar, GJ; Humphries, P

RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production
Li, GM; Li, DG; Xie, Q; Shi, Y; Jiang, S; Jin, YX

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain
Petri I. Mäkinen, Jonna K. Koponen, Anna-Mari Kärkkäinen, Tarja M. Malm, Kati H. Pulkkinen, Jari Koistinaho, Mikko P. Turunen, Seppo Ylä-Herttuala


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Oligonucleotide approaches

In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy
Qingsong Wang, HaiFang Yin, Patrizia Camelliti, Corinne Betts, Hong Moulton, Hyunil Lee, Amer F. Saleh, Michael J. Gait and Matthew J. A. Wood

In vivo comparison of 2 '-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping
Heemskerk, HA; de Winter, CL; de Kimpe, SJ; van Kuik-Romeijn, P; Heuvelmans, N; Platenburg, GJ; van Ommen, GJB; van Deutekom, JCT; Aartsma-Rus, A

Reduction of liver tumor necrosis factor-alpha expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis
Dong, L; Zuo, LS; Ma, SH; Gao, SY; Zhang, CY; Chen, JN; Zhang, JF

In vivo comparison of 2′-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping
Hans A. Heemskerk, Christa L. de Winter, Sjef J. de Kimpe, Petra van Kuik-Romeijn, Niki Heuvelmans, Gerard J. Platenburg, Gert-Jan B. van Ommen, Judith C. T. van Deutekom, Annemieke Aartsma-Rus

By-passing the nonsense mutation in the 4(CV) mouse model of muscular dystrophy by induced exon skipping
Mitrpant, C; Fletcher, S; Iversen, PL; Wilton, SD

Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2,enhances the replication of corrected cells following gene editing
Papaioannou, I; Disterer, P; Owen, JS

An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention
Suzuki, JI; Tezuka, D; Morishita, R; Isobe, M

Specific inhibition of epithelial Na channels by antisense oligonucleotides for the treatment of Na hyperabsorption in cystic fibrosis
Sobczak, K; Segal, A; Bangel-Ruland, N; Semmler, J; Van Driessche, W; Lindemann, H; Heermann, R; Weber, WM

Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis
Park, JH; Jo, JH; Kim, KH; Kim, SJ; Lee, WR; Park, KK; Park, JB

The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine
Wilsonl, KD; de Jong, SD; Kazem, M; Lall, R; Hope, MJ; Cullis, PR; Tam, YK

Topical delivery of interleukin-13 antisense oligonucleotides with cationic elastic liposome for the treatment of atopic dermatitis
Kim, ST; Lee, KM; Park, HJ; Jin, SE; Ahn, WS; Kim, CK

Long-term follow up of initial clinical cases with NF-kappa B decoy oligodeoxynucleotide transfection at the site of coronary stenting
Egashira, K; Suzuki, JI; Ito, H; Aoki, M; Isobe, M; Morishita, R


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