Chemistry - A European Journal

Cover image for Vol. 21 Issue 7

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.696

ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Recently Published Articles

  1. An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3-Ethylacetate-Substitued 3-Amino-2-Oxindoles: Formal Synthesis of AG-041R

    Kun Zhao, Tao Shu, Jiaqi Jia, Prof. Dr. Gerhard Raabe and Prof. Dr. Dieter Enders

    Article first published online: 28 JAN 2015 | DOI: 10.1002/chem.201406422

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    Traceless stereocontrol: The nucleophilic addition of ethyl nitroacetate to isatin-derived ketimines, followed by the removal of the nitro group, opens an efficient route to oxindole key intermediates of pyrroloindoline alkaloids and related pharmaceuticals of high enantiomeric purity. The Mannich or aza-Henry-type reaction is catalyzed by a dihydroquinine-based Brønsted base (see scheme). The easily scalable protocol is demonstrated by a formal synthesis of the bioactive lead compound AG-041R.

  2. Synthesis of Small-Sized, Porous, and Low-Toxic Magnetite Nanoparticles by Thin POSS Silica Coating

    Dr. Swee Kuan Yen, D. Prathyusha Varma, Wei Mei Guo, Dr. Vincent H. B. Ho, Dr. Vimalan Vijayaragavan, Dr. Parasuraman Padmanabhan, Prof. Kishore Bhakoo and Prof. Subramanian Tamil Selvan

    Article first published online: 28 JAN 2015 | DOI: 10.1002/chem.201406388

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    Nanoparticles in a new coat: Magnetic nanoparticles (MNPs) were thinly coated with polyhedral oligomeric silsesquioxanes (POSS), containing polyethylene glycol or octa(tetramethylammonium) as functional groups (see scheme). The coated MNPs have desirable properties, such as superparamagnetism, high colloidal stability, and low cytotoxicity, and can be used for bioimaging applications.

  3. Dialkylzinc-Mediated Cross-Coupling Reactions of Perfluoroalkyl and Perfluoroaryl Halides with Aryl Halides

    Hisano Kato, Dr. Keiichi Hirano, Daisuke Kurauchi, Naoyuki Toriumi and Prof. Dr. Masanobu Uchiyama

    Article first published online: 28 JAN 2015 | DOI: 10.1002/chem.201406292

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    RF values: A highly chemoselective perfluoroalkylation of aromatic halides is reported. Thermally stable perfluoroalkylzinc reagents, generated by rapid halogen–zinc exchange between diorganozinc and perfluoroalkyl halide species, couple with a wide range of aryl halides in the presence of copper catalyst, in moderate to high yields. The perfluoroalkylzinc species display good stability, as indicated by DFT calculations.

  4. Amino-Acid Derived Phosphine-Catalyzed Enantioselective 1,4-Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile

    Yangyan Li, Xiao Su, Wei Zhou, Dr. Wenbo Li and Prof. Dr. Junliang Zhang

    Article first published online: 28 JAN 2015 | DOI: 10.1002/chem.201406475

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    Cyclobutenones are explored as a new type of chiral 1,4-dipole four-carbon synthon, which readily undergoes asymmetric intermolecular 1,4-dipolar spiroannulation with isatylidenemalononitrile in the presence of amino-acid derived chiral phosphine catalyst to furnish enantioenriched 3-spirocyclohexenone 2-oxindoles in good yield with up to 87 % ee.

  5. Initial Radical Cation Pathway in the Mo2Cl10-Mediated Dehydrogenative Arene Coupling

    Dr. Jana Leppin, Moritz Schubert, Prof. Dr. Siegfried R. Waldvogel and Prof. Dr. Katja Heinze

    Article first published online: 28 JAN 2015 | DOI: 10.1002/chem.201406522

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    Signs of radicalization: Experimental (EPR) and theoretical (DFT) evidence is provided for radical cation formation as the initial step in the Mo2Cl10-mediated dehydrogenative arene coupling. The initial electron transfer from methoxyarenes to molybdenum proceeds via an inner sphere mechanism.