Chemistry - A European Journal

Cover image for Vol. 21 Issue 15

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.696

ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Recently Published Articles

  1. Pd/C-Catalyzed Cyclizative Cross-Coupling of Two ortho-Alkynylanilines under Aerobic Conditions: Synthesis of 2,3′-Bisindoles

    Dr. Bo Yao, Dr. Qian Wang and Prof. Dr. Jieping Zhu

    Article first published online: 30 MAR 2015 | DOI: 10.1002/chem.201501020

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    Good to excellent yields of the 2,3′-bisindoles 3 were obtained, through the formation of three chemical bonds (two C[BOND]N, one C[BOND]C), in the Pd-catalyzed reaction of two o-alkynylanilines 1 and 2 under mild aerobic conditions. Mechanistic studies suggested that the two catalytic cycles leading to two indole rings were temporally separated. The aminopalladation of 3-alkynylindoles, the product of the first catalytic cycle occurred only after all the N,N-dialkyl-o-alkynylanilines 1 were consumed. This work represents a rare example in which Pd/C was used as a pre-catalyst for the PdII-catalyzed oxidative transformations.

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    Structure and Mechanism Leading to Formation of the Cysteine Sulfinate Product Complex of a Biomimetic Cysteine Dioxygenase Model

    Madleen Sallmann, Suresh Kumar, Dr. Petko Chernev, Dr. Joscha Nehrkorn, Dr. Alexander Schnegg, Dr. Devesh Kumar, Prof. Dr. Holger Dau, Prof. Dr. Christian Limberg and Dr. Sam P. de Visser

    Article first published online: 30 MAR 2015 | DOI: 10.1002/chem.201500644

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    Model meets enzyme: DFT calculations and XAS investigations on a truly biomimetic model for the cysteine dioxygenase reveal that the sulfinate product is bound in a η2-O,O-binding mode (see scheme). This provides the first experimental support for corresponding suggestions that had been made previously for the enzyme itself.

  3. Liquid-Crystalline Properties of trans-A2B2-Porphyrins with Extended π-Electron Systems

    Dr. Mirosław Salamończyk, Dr. Damian Pociecha, Dr. Agnieszka Nowak-Król, Dr. Dominik Koszelewski, Prof. Daniel T. Gryko and Prof. Ewa Górecka

    Article first published online: 30 MAR 2015 | DOI: 10.1002/chem.201500295

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    Smectic porphyrins: The replacement of two meso-aryl groups of porphyrins with phenylethynyl or naphthylethynyl substituents increases the melting points of the resultant porphyrins by ∼100 °C and has allowed thermotropic liquid crystallinity to be demonstrated, including a unique switch from columnar to smectic phase.

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    Triggering the Directional Selectivity of a Ring-Closure Reaction Leads to Pyridoazacarbazoles with Anticancer Properties

    Tamara N. Steinhauer, Daniel S. Längle, Dr. Christopher Meier, Dr. Ulrich Girreser, Dr. Lars Stenzel, Prof. Dr. Dieter Heber and Prof. Dr. Bernd Clement

    Article first published online: 30 MAR 2015 | DOI: 10.1002/chem.201500156

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    One step to success! Just one step and a facile and efficient synthetic procedure leads to 5,6-dihydro-11H-pyrido[3,2-i]-1-azacarbazoles with highly potent antitumor activity. The aromatic substituent is cleaved easily gaining access to the corresponding hitherto unknown tetracyclic scaffold (see scheme; DMPU=1,3-dimethyl-3,4,5,6-tetrahydropyrimidin-2-(1H)-one.).

  5. Surface-Tuned Electron Transfer and Electrocatalysis of Hexameric Tyrosine-Coordinated Heme Protein (HTHP)

    Dr. Lei Peng, Dr. Tillmann Utesch, Dr. Aysu Yarman, Dr. Jae-Hun Jeoung, Silke Steinborn, Prof. Dr. Holger Dobbek, Dr. Maria Andrea Mroginski, Johannes Tanne, Prof. Dr. Ulla Wollenberger and Prof. Dr. Frieder W. Scheller

    Article first published online: 30 MAR 2015 | DOI: 10.1002/chem.201405932

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    Heme theme: Electrochemistry and QCM were used to characterize hexameric tyrosine-coordinated heme protein (HTHP) immobilized on bare carbon or on Au electrodes modified by differently charged self-assembled monolayers. Experimental results are in line with theoretical calculations; HTHP at negatively charged surfaces shows both direct electron transfer of the heme centers and bioelectrocatalysis.