Chemistry - A European Journal
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Chefredakteurin: Ilka Parchmann
Impact Factor: 5.696
ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)
Online ISSN: 1521-3765
Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry
October 08, 2014
The Nobel Prize in Chemistry 2014 has been awarded jointly to Eric Betzig, Howard Hughes Medical Institute, Ashburn, VA, USA, Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Göttingen, and German Cancer Research Center, Heidelberg, Germany, and William E. Moerner, Stanford University, CA, USA, "for the development of super-resolved fluorescence microscopy".
Work from Stefan Hell and his group on masked rhodamine dyes and their applications in light microscopy applications was recently highlighted on the front cover of Chemistry—A European Journal.
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Recently Published Articles
- You have free access to this contentCelebratory Chemistry! (pages 5–11)
Dr. Neville Compton
Article first published online: 22 DEC 2014 | DOI: 10.1002/chem.201406300
Time to celebrate: This issue marks the start of the 20th anniversary of Chemistry–A European Journal. The journal has played a major role in changing the face of chemistry. Its history has featured top papers from top authors, among which 13 Nobel Laureates have published over 100 research articles in the journal.
- Practical Route to the Left Wing of CTX1B and Total Syntheses of CTX1B and 54-deoxyCTX1B
Dr. Shuji Yamashita , Dr. Katsutoshi Takeuchi, Takuya Koyama, Prof. Dr. Yujiro Hayashi and Prof. Dr. Masahiro Hirama
Article first published online: 21 DEC 2014 | DOI: 10.1002/chem.201405629
Try, try again! Ciguatoxins, the principal causative agents of ciguatera seafood poisoning, are extremely large polycyclic ethers. A route to the left wing utilizing radical cyclization realized a practical total syntheses of CTX1B and 54-hydroxyCTX1B (see figure).
- On the Stability of PtIV Pro-Drugs with Haloacetato Ligands in the Axial Positions
Dr. Ezequiel Wexselblatt, Dr. Raji Raveendran, Sawsan Salameh, Dr. Aviva Friedman-Ezra, Dr. Eylon Yavin and Prof. Dan Gibson
Article first published online: 21 DEC 2014 | DOI: 10.1002/chem.201405467
Pro-drugs for anticancer agents: PtIV complexes with haloacetato ligands in the axial positions can be unstable in biologically relevant conditions and can undergo hydrolysis in cell culture medium or plasma, which results in the loss of the axial haloacetato ligands (see scheme).
- Mechanism of [3+2] Cycloaddition of Alkynes to the [Mo3S4(acac)3(py)3][PF6] Cluster
Dr. Jose Ángel Pino-Chamorro, Dr. Artem L. Gushchin, Prof. M. Jesús Fernández-Trujillo, Dr. Rita Hernández-Molina, Dr. Cristian Vicent, Dr. Andrés G. Algarra and Prof. Manuel G. Basallote
Article first published online: 21 DEC 2014 | DOI: 10.1002/chem.201405518
How does your cluster grow? Kinetic and DFT studies on the mechanism of reaction between the [Mo3S4(acac)3(py)3][PF6] cluster and alkynes indicate that the first step consists of [3+2] cycloaddition between the alkyne and a Mo(μ-S)2 moiety of the cluster (see scheme), and the different rates observed are rationalized on the basis of the activation strain model.
- Enantioselective Michael Addition of Water
Bi-Shuang Chen, Dr. Verena Resch, Dr. Linda G. Otten and Prof. Dr. Ulf Hanefeld
Article first published online: 21 DEC 2014 | DOI: 10.1002/chem.201405579
Water as substrate and solvent: The Michael hydratase from Rhodococcus rhodochrous ATCC 17895 enables the direct enantioselective synthesis of secondary and tertiary alcohols in good yields and excellent enantioselectivities by a direct Michael addition of water in water. Deuterium labeling studies demonstrate that the water addition proceeds exclusively with anti-stereochemistry.