Chemistry - A European Journal

Cover image for Vol. 21 Issue 29

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.731

ISI Journal Citation Reports © Ranking: 2014: 22/157 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Recently Published Articles

  1. Concise Total Synthesis of Ivorenolide B

    Felix Ungeheuer and Prof. Alois Fürstner

    Article first published online: 3 JUL 2015 | DOI: 10.1002/chem.201501765

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    Terminal, not fatal: Although the total synthesis of the immunosuppressive compound ivorenolide B (see scheme) relies on the cyclization of a precursor endowed with several structural elements that alkyne metathesis could not handle until recently, the macrocyclization proceeded smoothly when catalyzed by a molybdenum alkylidyne carrying silanolates as ancillary ligands. Moreover, the present study showcases how macrocyclic 1,3-diynes can be elaborated into unconventional cyclophane products.

  2. A Versatile Approach to CF3-Containing 2-Pyrrolidones by Tandem Michael Addition–Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors

    Dr. Natalia Mateu, Myriam Ciordia, Dr. Oscar Delgado, Dr. María Sánchez-Roselló, Dr. Andrés A. Trabanco, Dr. Michiel Van Gool, Dr. Gary Tresadern, Laura Pérez-Benito and Prof. Dr. Santos Fustero

    Article first published online: 3 JUL 2015 | DOI: 10.1002/chem.201501662

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    All about that base: In the design of β-secretase 1 (BACE1; see scheme) inhibitors for use in Alzheimer’s disease, control of the basicity is crucial for combining efficient interaction in the active site and central penetration of the blood–brain barrier. An unprecedented Michael addition–lactamization process allowed the preparation of a series of cell-permeable BACE1 ligands displaying inhibitory activities in the low nanomolar range.

  3. Rotaxanes Capped with Host Molecules: Supramolecular Behavior of Adamantylated Bisimidazolium Salts Containing a Biphenyl Centerpiece

    Petra Branná, Dr. Michal Rouchal, Dr. Zdeňka Prucková, Dr. Lenka Dastychová, Dr. René Lenobel, Dr. Tomáš Pospíšil, Dr. Kamil Maláč and Dr. Robert Vícha

    Article first published online: 3 JUL 2015 | DOI: 10.1002/chem.201501353

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    Who’d have guest: Bisimidazolium salts with one central biphenyl binding site and two terminal adamantyl binding sites are prepared and used as guest molecules for construction of self-assembled (pseudo)rotaxanes in aqueous solution. Guests with structures that offer greater hindrance to the cucurbit[7]uril (CB7) and β-cyclodextrin (β-CD) host molecules’ free slippage over the guest axle are able to bind a higher number of host units.

  4. Single-Site Zeolite-Anchored Organoiridium Carbonyl Complexes: Characterization of Structure and Reactivity by Spectroscopy and Computational Chemistry

    Claudia Martinez-Macias, Dr. Mingyang Chen, Prof. David A. Dixon and Prof. Bruce C. Gates

    Article first published online: 3 JUL 2015 | DOI: 10.1002/chem.201501277

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    A family of HY zeolite-supported organoiridium carbonyl complexes was formed by reaction of Ir(CO)2(acac) (acac=acetylacetonate) to form supported Ir(CO)2 complexes, which were treated with flowing gas-phase reactants at 298 K and 1 bar. The crystalline support, with its nearly uniform array of bonding sites for the supported iridium species, allowed precise structure determinations, with the experimental results in good agreement with DFT calculations.

  5. Interpreted Recognition Process: A Highly Sensitive and Selective Luminescence Chemosensor

    Dr. Huabin Zhang, Dr. Ping Hu, Dr. Qikai Zhang, Prof. Mingdong Huang, Prof. Can-Zhong Lu, Dr. Victor Malgras, Prof. Yusuke Yamauchi, Prof. Jian Zhang and Prof. Shao-Wu Du

    Article first published online: 3 JUL 2015 | DOI: 10.1002/chem.201501225

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    A luminescence-sensing technique has been developed, which shows fast response, highly selectivity, and ultrasensitive measurement of Fe3+ or Cr3+ in aqueous solution and living cells. The process has been observed using ESI-MS analysis, and the ligand-transfer-induced luminescence-quenching mechanism was interpreted. This work extends the potential applications of lanthanide coordination compounds (LnCCs) to biological and environmental areas.

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