Chemistry - A European Journal

Cover image for Vol. 21 Issue 15

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.696

ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Recently Published Articles

  1. Intramolecular Carbolithiation of Heterosubstituted Alkynes: An Experimental and Theoretical Study

    Dr. Rudy Lhermet, Maha Ahmad, Clémence Hauduc, Dr. Catherine Fressigné, Dr. Muriel Durandetti and Dr. Jacques Maddaluno

    Article first published online: 26 MAR 2015 | DOI: 10.1002/chem.201500201

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    Triple effect: The carbolithiation of heterosubstituted alkynes constitutes a new, versatile, and stereocontrolled source of vinyl carbenoids (see scheme). Systematic experimental and DFT investigations on the regio- and stereoselectivity of this reaction reveal the origin of the control of the double bond configuration during the cyclization step.

  2. Organomagnesium-Catalyzed Isomerization of Terminal Alkynes to Allenes and Internal Alkynes

    Dr. Raphaël Rochat, Koji Yamamoto, Michael J. Lopez, Haruki Nagae, Dr. Hayato Tsurugi and Prof. Dr. Kazushi Mashima

    Article first published online: 26 MAR 2015 | DOI: 10.1002/chem.201500179

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    Selective and important: Magnesium complexes bearing aminoamido ligands are precursors for the isomerization of terminal alkynes to allenes and further to internal alkynes through temporally separated autotandem catalysis (see picture). The catalytically active tetraalkynyl complexes consist of a tautomeric mixture of alkynyl-, allenyl-, and propargylmagnesium species.

  3. Synthesis of 1-C-Glycoside-Linked Lipid II Analogues Toward Bacterial Transglycosylase Inhibition

    Dr. Cheng-Kun Lin, Kuo-Ting Chen, Chia-Ming Hu, Wen-Yi Yun and Prof. Dr. Wei-Chieh Cheng

    Article first published online: 26 MAR 2015 | DOI: 10.1002/chem.201406629

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    An unbreakable bond: The preparation of Lipid II analogues containing a 1-C-glycoside linkage between a disaccharide moiety and a pyrophosphate- or pyrophosphonate-lipid moiety is described (see scheme). A synthesis of the 1-C-vinyl disaccharide intermediate has been developed that allows easy preparation of the desired molecules. The inhibition study shows how a subtle structural modification results in dramatically different potency toward bacterial transglycosylase.

  4. Enantioselective Allylation of (2E,4E)-2,4-Dimethylhexadienal: Synthesis of (5R,6S)-(+)-Pteroenone

    Petr Koukal and Prof. Dr. Martin Kotora

    Article first published online: 26 MAR 2015 | DOI: 10.1002/chem.201500050

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    Allylation and crotylation of an α,β,γ,δ-unsaturated aldehyde was studied under various conditions. The asymmetric induction was as high as 96 % ee. The anti-crotylation product was used as the crucial intermediate for the enantioselective synthesis of (5R,6S)-(+)-pteroenone, a defensive metabolite of Clione Antarctica.

  5. Selective Nitrogen Functionalization of Graphene by Bucherer-Type Reaction

    Dr. Chun Kiang Chua, Prof. Zdeněk Sofer, Jan Luxa and Prof. Martin Pumera

    Article first published online: 26 MAR 2015 | DOI: 10.1002/chem.201405748

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    Amino-functionalized graphene: Graphene functionalized with amino groups was obtained by a Bucherer-type reaction of graphite oxide with sodium hydrogensulfite/ammonia under hydrothermal conditions, which selectively converted hydroxyl to amino groups (see figure). The functionalization is only effective on graphite oxide produced by the Hummers oxidation method as opposed to the Hofmann oxidation method.