Chemistry - A European Journal

Cover image for Vol. 20 Issue 40

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.696

ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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August 27, 2014

Celebrating Young Chemists

Cover image for Vol. 20 Issue 34 Check out the special issue dedicated to young European chemists. This issue has been together to celebrate the past participants of the European Young Chemist Award (EYCA), presented at the first four EuCheMS Congresses, and to highlight the great diversity of research currently being conducted by young chemists from all over the world.

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Recently Published Articles

  1. You have free access to this content
    Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes

    Dr. Devarajulu Sureshkumar, Dr. Venkataraman Ganesh, Dr. Naoya Kumagai and Prof. Dr. Masakatsu Shibasaki

    Article first published online: 22 SEP 2014 | DOI: 10.1002/chem.201404808

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    Direct catalytic addition of alkylnitriles to aldehydes allows for an atom-economical access to β-hydroxynitriles under proton transfer conditions. A transition metal/N-heterocyclic carbene (NHC) complex prepared from [{Rh(OMe)(cod)}2] and imidazolium-based carbene was identified as an effective catalyst to promote the reaction with as little as 1.25 mol % of catalyst loading. The corresponding Rh complex derived from chiral triazolium salt rendered the reaction moderately enantioselective.

  2. Three-Way Cooperativity in d8 Metal Complexes with Ligands Displaying Chemical and Redox Non-Innocence

    Dr. Naina Deibel, Stephan Hohloch, Dr. David Schweinfurth, Fritz Weisser, Dr. Anita Grupp and Prof. Dr. Biprajit Sarkar

    Article first published online: 22 SEP 2014 | DOI: 10.1002/chem.201403276

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    Spectroelectrochemistry: Site-decoupled proton- and electron-transfer steps have been characterized by using an arsenal of crystallographic, spectroscopic, and spectroelectrochemical methods. The protons and electrons were shown to participate in cooperative bond-activation reactions (see scheme).

  3. Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

    Dr. Udaya Kiran Marelli, Dr. Andreas O. Frank, Dr. Bernhard Wahl, Dr. Valeria La Pietra, Prof. Ettore Novellino, Dr. Luciana Marinelli, Dr. Eberhardt Herdtweck, Prof. Dr. Michael Groll and Prof. Dr. Horst Kessler

    Article first published online: 22 SEP 2014 | DOI: 10.1002/chem.201403839

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    Ligand-oriented drug design (LODD): Extensive structural studies of Cilengitide (cyclo(RGDf(NMe)Val)) showed that the NMR-based conformations (top left) closely resemble its receptor (αvβ3 integrin) bound conformation while the X-ray structure of pure Cilengitide is different (top right). Docking of the solid-state conformation of Cilengitide to αvβ3 integrin failed to represent some key ligand–receptor interactions which are present in the Cilengitide–αvβ3 integrin X-ray complex.

  4. Nef Reaction with Molecular Oxygen in the Absence of Metal Additives, and Mechanistic Insights

    Shigenobu Umemiya, Kentaro Nishino, Prof. Dr. Itaru Sato and Prof. Dr. Yujiro Hayashi

    Article first published online: 22 SEP 2014 | DOI: 10.1002/chem.201403475

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    Who needs metals! The Nef reaction has been developed under mildly basic conditions with molecular oxygen as an oxidant without the need for metal additives (see scheme). The reaction protocol is both mild and general, and tolerates acid- and base-labile functionality or protecting groups. Mechanistically, the addition of nitronate ion and molecular oxygen is proposed to proceed initially through a single-electron transfer event, as indicated by radical clock experiments. This ultimately generates a putative 1,1-dioxirane, which reacts further with a second nitronate ion to generate the ketone.

  5. 2,2′-Bipyridine-Based Dendritic Structured Compounds for Second Harmonic Generation

    Dr. Marina Büchert, Torben Steenbock, Christian Lukaschek, Marie C. Wolff, Prof. Dr. Carmen Herrmann and Prof. Dr. Jürgen Heck

    Article first published online: 22 SEP 2014 | DOI: 10.1002/chem.201404001

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    Living in harmony: Cooperative effects in triple-stranded dipolar NLO chromophores provide an enhanced second harmonic generation (SHG) compared to the threefold SHG of the corresponding single-strand chromophores (see figure). Theoretical studies confirm that an interstrand excitation (ISE) may be responsible for this cooperative effect.