Chemistry - A European Journal

Cover image for Vol. 21 Issue 32

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.731

ISI Journal Citation Reports © Ranking: 2014: 22/157 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Recently Published Articles

  1. Non-Uniform Sampling and J-UNIO Automation for Efficient Protein NMR Structure Determination

    Dr. Tatiana Didenko, Dr. Andrew Proudfoot, Dr. Samit Kumar Dutta, Dr. Pedro Serrano and Prof. Dr. Kurt Wüthrich

    Article first published online: 28 JUL 2015 | DOI: 10.1002/chem.201502544

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    NMR time saver: A non-uniform sampling of 3D heteronuclear-resolved [1H,1H]-NOESY spectra into the J-UNIO protocol for automated protein-structure determination is described, which resulted in high-quality NMR structures obtained with two- to three-fold reduced NMR measurement time. The robustness of the approach by comparing protein NMR structures obtained using conventional NMR measurements and non-uniform sampling is demonstrated, and guidelines for the acquisition parameters to be used for NMR structure determination of soluble proteins are provided.

  2. Synthesis of Cembranoid Analogues through Ring-Closing Metathesis of Terpenoid Precursors: A Challenge Regarding Ring-Size Selectivity

    Tanja Heidt, Dr. Angelika Baro, Prof. Andreas Köhn and Prof. Sabine Laschat

    Article first published online: 28 JUL 2015 | DOI: 10.1002/chem.201502051

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    Getting the right size: Macrocyclization of terpenoids with competing double bonds under Grubbs II catalysis requires a critical balance of steric effects to give cembranoid derivatives (see scheme), otherwise six-membered ring formation or cross metathesis were favored. DFT calculations helped to explain the experimental results.

  3. Intramolecular Redox-Mannich Reactions: Facile Access to the Tetrahydroprotoberberine Core

    Longle Ma and Prof. Dr. Daniel Seidel

    Article first published online: 28 JUL 2015 | DOI: 10.1002/chem.201501667

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    Cyclic amines, such as pyrrolidine and 1,2,3,4-tetrahydroisoquinoline, undergo redox-annulations with 2-formylaryl malonates. This redox-Mannich process provides regioisomers of classic Reinhoudt reaction products as an entry to the tetrahydroprotoberberine core, enabling a formal total synthesis of (±)-thalictricavine. An unusually mild amine-promoted dealkoxycarbonylation was discovered in the course of these studies.

  4. Diastereo- and Enantioselective Iridium Catalyzed Carbonyl (α-Cyclopropyl)allylation via Transfer Hydrogenation

    Dr. Ryosuke Tsutsumi, Dr. Suckchang Hong and Prof. Michael J. Krische

    Article first published online: 28 JUL 2015 | DOI: 10.1002/chem.201502499

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    Alcohol Solves Problems: Chiral iridium catalysts modified by (R)-SEGPHOS catalyze the transfer hydrogenative coupling of racemic α-cyclopropyl allyl acetate with diverse primary alcohols with good anti-diastereo- and exceptional enantioselectivity. These processes represent the first diastereo- and enantioselective carbonyl (α-cyclopropyl)allylations.

  5. A Highly Effective Ruthenium System for the Catalyzed Dehydrogenative Cyclization of Amine–Boranes to Cyclic Boranes under Mild Conditions

    Dr. Christopher J. Wallis, Dr. Gilles Alcaraz, Dr. Alban S. Petit, Dr. Amalia I. Poblador-Bahamonde, Dr. Eric Clot, Dr. Christian Bijani, Dr. Laure Vendier and Dr. Sylviane Sabo-Etienne

    Article first published online: 28 JUL 2015 | DOI: 10.1002/chem.201501569

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    Mild-mannered cyclization: The ruthenium-catalyzed dehydrogenative cyclization (CDC) process has been investigated by using a variety of amine–borane substrates (see figure). The reaction leads to the formation of the corresponding NB(H)N- and NB(H)O-containing cyclic aminoboranes and involves the formation of a bis-σ-borane ruthenium intermediate complex.