Chemistry - A European Journal

Cover image for Vol. 20 Issue 52

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.696

ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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October 08, 2014

Prize-winning chemistry!

Prize-winning chemistry!

The Nobel Prize in Chemistry 2014 has been awarded jointly to Eric Betzig, Howard Hughes Medical Institute, Ashburn, VA, USA, Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Göttingen, and German Cancer Research Center, Heidelberg, Germany, and William E. Moerner, Stanford University, CA, USA, "for the development of super-resolved fluorescence microscopy".

Work from Stefan Hell and his group on masked rhodamine dyes and their applications in light microscopy applications was recently highlighted on the front cover of Chemistry—A European Journal.

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Recently Published Articles

  1. Effect of Solvent and Protonation/Deprotonation on Electrochemistry, Spectroelectrochemistry and Electron-Transfer Mechanisms of N-Confused Tetraarylporphyrins in Nonaqueous Media

    Songlin Xue, Prof. Zhongping Ou, Lina Ye, Guifen Lu, Yuanyuan Fang, Xiaoqin Jiang and Prof. Karl M. Kadish

    Article first published online: 17 DEC 2014 | DOI: 10.1002/chem.201405570

    Thumbnail image of graphical abstract

    Are you confused? A series of N- confused meso-substituted free-base tetraarylporphyrins was synthesized and characterized as to their electrochemistry and spectroelectrochemistry in CH2Cl2, PhCN, and DMF containing 0.1 M tetra-n-butylammonium perchlorate. The effect of the solvent and protonation/deprotonation reactions on the UV/Vis spectra, redox potentials and reduction/oxidation mechanisms is discussed with comparisons made to data and mechanisms for the structurally related free-base corroles and porphyrins (see figure).

  2. Combined Experimental and Computational Investigations of Rhodium-Catalysed C[BOND]H Functionalisation of Pyrazoles with Alkenes

    Dr. Andrés G. Algarra, Prof. David L. Davies, Dr. Qudsia Khamker, Prof. Stuart A. Macgregor, Dr. Claire L. McMullin, Kuldip Singh and Dr. Barbara Villa-Marcos

    Article first published online: 17 DEC 2014 | DOI: 10.1002/chem.201405550

    Thumbnail image of graphical abstract

    Selective vinylation: The rhodium-catalysed oxidative coupling of alkenes and 3-aryl-5-R-pyrazoles gives vinylated products, some of which can cyclise through intramolecular Michael reactions (see scheme). DFT calculations show a clear preference for 2,1-insertion with β-H elimination, calculated to favour the trans vinyl products in all cases, as found experimentally.

  3. Organocatalytic Asymmetric Cascade Reactions of 7-Vinylindoles: Diastereo- and Enantioselective Synthesis of C7-Functionalized Indoles

    Prof. Dr. Feng Shi, Hong-Hao Zhang, Xiao-Xue Sun, Jing Liang, Tao Fan and Prof. Shu-Jiang Tu

    Article first published online: 17 DEC 2014 | DOI: 10.1002/chem.201405245

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    Cascade reactions of 7-vinylindoles: The first catalytic asymmetric cascade reaction of 7-vinylindoles has been established by the rational design of such substrates. Cascade reactions with isatin-derived 3-indolylmethanols catalyzed by chiral phosphoric acid (CPA; see scheme) allow the diastereo- and enantioselective synthesis of C7-functionalized indoles as well as the construction of cyclopenta[b]indole and spirooxindole frameworks (all >95:5 d.r., 94–>99 % ee).

  4. You have free access to this content
    Anti-Cancer Iron(II) Complexes of Pentadentate N-Donor Ligands: Cytotoxicity, Transcriptomics Analyses, and Mechanisms of Action

    Dr. Wai-Lun Kwong, Dr. Chun-Nam Lok, Chun-Wai Tse, Dr. Ella Lai-Ming Wong and Prof. Dr. Chi-Ming Che

    Article first published online: 17 DEC 2014 | DOI: 10.1002/chem.201404749

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    Two iron(II) complexes exert potent cytotoxicities to cancer cells via different pathways, both leading to cellular DNA damage and apoptosis. The mechanisms of cytotoxic action of these iron(II) complexes are similar to that of a cell-permeable iron chelator, as revealed by transcriptomic analyses, and are significantly affected by the ligand structure.

  5. NMR Studies of Active-Site Properties of Human Carbonic Anhydrase II by using 15N-Labeled 4-Methylimidazole as a Local Probe and Histidine Hydrogen-Bond Correlations

    Dr. Ilya G. Shenderovich, Dr. Stepan B. Lesnichin, Dr. Chingkuang Tu, Prof. Dr. David N. Silverman, Dr. Peter M. Tolstoy, Prof. Dr. Gleb S. Denisov and Prof. Dr. Hans-Heinrich Limbach

    Article first published online: 17 DEC 2014 | DOI: 10.1002/chem.201404083

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    Chemical-shift correlations: 15N-Labeled 4-methylimidazole has been studied as a local probe of the environment by using NMR spectroscopy in polar wet Freon, in water, and in solid samples of the mutant H64A of human carbonic anhydrase II. The possible hydrogen-bond clusters formed and the mechanism of tautomerism are discussed. Information about the imidazole hydrogen-bond geometries has been obtained by correlations (see figure).