Chemistry - A European Journal
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern
Impact Factor: 5.696
ISI Journal Citation Reports © Ranking: 2013: 22/148 (Chemistry Multidisciplinary)
Online ISSN: 1521-3765
Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry
Recently Published Articles
- Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport
Dr. Udaya Kiran Marelli, M. Sc. Jacqueline Bezençon, B. Sc. Eduard Puig, Prof. Dr. Beat Ernst and Prof. Dr. Horst Kessler
Article first published online: 27 APR 2015 | DOI: 10.1002/chem.201501270
Permeability properties of enantiomeric pairs of three polar and two lipophilic peptides are investigated with an artificial membrane permeability assay (PAMPA) and a Caco-2 cell model to demonstrate the participation of carrier-mediated transporters. All enantiomer peptide pairs exhibited identical lipophilicity and passive permeability, whereas only enantiomeric polar peptides showed noticeable differences in permeability across Caco-2 cells, suggesting a carrier-mediated transport.
- A Visible Light Photocatalytic Cross-Dehydrogenative Coupling/Dehydrogenation/6π-Cyclization/Oxidation Cascade: Synthesis of 12-Nitroindoloisoquinolines from 2-Aryltetrahydroisoquinolines
Fabian Rusch, Lisa-Natascha Unkel, Dirk Alpers, Dr. Frank Hoffmann and Prof. Dr. Malte Brasholz
Article first published online: 27 APR 2015 | DOI: 10.1002/chem.201500612
In one pot: A visible light-induced photocatalytic cross-dehydrogenative coupling (CDC)/dehydrogenation/6π-cyclization/oxidation cascade converts common 2-aryl-1,2,3,4-tetrahydroisoquinolines into 12-nitro-substituted tetracyclic indolo[2,1-a]isoquinoline derivatives. Key to this new one-pot transformation is the presence of K3PO4 as a base and amino anthraquinone derivatives appear as superior organic photocatalysts.
- Enantiogroup-Differentiating Biocatalytic Reductions of Prochiral Cs-Symmetrical Dicarbonyl Compounds to meso Compounds
Marc Skoupi, Dr. Carine Vaxelaire, Prof. Dr. Carsten Strohmann, Prof. Dr. Mathias Christmann and Prof. Dr. Christof M. Niemeyer
Article first published online: 27 APR 2015 | DOI: 10.1002/chem.201500741
Remote control: The biocatalytic desymmetrization of Cs-symmetrical 1,7-dicarbonyl compound 1 (see scheme) enables the sequential synthesis of remote 1,7-meso-diols by utilizing ketoreductases. The excellent enantiogroup differentiation of GRE2 towards a prostereogenic substituent facilitates the designated synthesis of both stereomeric meso-compounds.
- A New Simple Chromo-fluorogenic Probe for NO2 Detection in Air
L. Alberto Juárez, Prof. Ana M. Costero, Dr. Félix Sancenón, Prof. Ramón Martínez-Máñez, Prof. Margarita Parra and Dr. Pablo Gaviña
Article first published online: 27 APR 2015 | DOI: 10.1002/chem.201500608
NO2 risk, NO2 fun: A new chromo-fluorogenic probe for NO2 detection in gas phase has been developed. A clear colour change from colourless to yellow (see figure) together with an emission quenching was observed when the probe reacted with NO2. The system was successfully applied to the detection of NO2 in realistic atmospheric conditions.
- Solid Polymer Substrates and Coated Fibers Containing 2,4,6-Trinitrobenzene Motifs as Smart Labels for the Visual Detection of Biogenic Amine Vapors
Dr. Jesús L. Pablos, Dr. Saúl Vallejos, Dr. Asunción Muñoz, Prof. Dr. María J. Rojo, Dr. Felipe Serna, Prof. Dr. Félix C. García and Prof. Dr. José M. García
Article first published online: 27 APR 2015 | DOI: 10.1002/chem.201501365
Is this fish fresh? Polymers containing chemically anchored trinitrobenzene motifs are exploited as colorimetric sensors for biogenic amine vapors. Tractable transparent films and coated fibers as chromogenic smart labels are reported. Therefore, the color change of these materials upon interaction/detection of volatile, amines produced in food spoilage, specifically in the deterioration of fish or meat, can be used as a visual test for food freshness.