Chemistry - A European Journal

Cover image for Vol. 21 Issue 37

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.731

ISI Journal Citation Reports © Ranking: 2014: 22/157 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

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Ruthenium-Immobilized Periodic Mesoporous Organosilica: Synthesis, Characterization, and Catalytic Application for Selective Oxidation of Alkanes

Nobuhiro Ishito, Dr. Hirokazu Kobayashi, Dr. Kiyotaka Nakajima, Yoshifumi Maegawa, Dr. Shinji Inagaki, Dr. Kenji Hara and Prof. Dr. Atsushi Fukuoka

Ruthenium-Immobilized Periodic Mesoporous Organosilica: Synthesis, Characterization, and Catalytic Application for Selective Oxidation of AlkanesRu species were immobilized in an isolated form directly on 2,2’-bypyridine groups in a periodic mesoporous organosilica (PMO) framework. The Ru-immobilized PMO oxidizes the tertiary C[BOND]H bonds of adamantane with significantly high regioselectivity. Moreover, the catalyst converts cis-decalin to cis-9-decalol with complete retention of the substrate stereochemistry (see scheme).

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Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands

Dr. Sara Sattin, Dr. Jiahui Tao, Dr. Gerolamo Vettoretti, Dr. Elisabetta Moroni, Dr. Marzia Pennati, Dr. Alessia Lopergolo, Dr. Laura Morelli, Dr. Antonella Bugatti, Dr. Abbey Zuehlke, Dr. Mike Moses, Dr. Thomas Prince, Dr. Toshiki Kijima, Dr. Kristin Beebe, Dr. Marco Rusnati, Dr. Len Neckers, Dr. Nadia Zaffaroni, Prof. David A. Agard, Prof. Anna Bernardi and Dr. Giorgio Colombo

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric LigandsA little goes a long way: Molecular dynamics-based design provides a new series of allosteric activators of the Hsp90 molecular chaperone. These probes affect the viability of cancer cell lines for which proper functioning of Hsp90 is necessary.

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Callipeltosides A, B and C: Total Syntheses and Structural Confirmation

Dr. James R. Frost, Dr. Colin M. Pearson, Prof. Thomas N. Snaddon, Dr. Richard A. Booth, Dr. Richard M. Turner, Dr. Johan Gold, Dr. David M. Shaw, Prof. Matthew J. Gaunt and Prof. Steven V. Ley

Callipeltosides A, B and C: Total Syntheses and Structural ConfirmationEasy as A, B, C: The entire callipeltoside family of natural products have been synthesised in a highly convergent manner. This account details our full research effort and presents further evidence to aid in the stereochemical assignment of the glycosidic linkages present in callipeltosides B and C (see scheme).

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Persistent Dialkylsilanone Generated by Dehydrobromination of Dialkylbromosilanol

Dr. Shintaro Ishida, Dr. Takashi Abe, Dr. Fumiya Hirakawa, Tomoyuki Kosai, Katsuhiro Sato, Prof. Dr. Mitsuo Kira and Prof. Dr. Takeaki Iwamoto

Persistent Dialkylsilanone Generated by Dehydrobromination of DialkylbromosilanolPersistent diorganosilanone in solution! A persistent diorganosilanone was synthesized by a new synthetic method, dehydrobromination of the corresponding diorganobromosilanol with tris(trimethylsilyl)silyl potassium in solution at −80 °C (see scheme). The silanone was characterized by NMR and IR spectroscopy, and by chemical trapping. In 29Si NMR spectrum in [D8]toluene, the signal due to the unsaturated silicon nuclei was observed at 128.7 ppm.

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