Chemistry - A European Journal
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern
Impact Factor: 5.731
ISI Journal Citation Reports © Ranking: 2014: 22/157 (Chemistry Multidisciplinary)
Online ISSN: 1521-3765
Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemistrySelect, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry
The cover picture shows the computer-modeled ternary complex between the enzyme catechol O-methyltransferase (COMT) (yellow), Mg2+ (magenta), and a bisubstrate inhibitor (orange). The Conolly surface of the bisubstrate inhibitor is shown. Inhibition of COMT is an important approach for developing new therapeutic treatments in Parkinson's disease. For the first time a bisubstrate inhibitor for COMT was synthesized and its inhibition mechanism elucidated. This work is describe in more detail by F. Diederich et al. on p. 971ff.