Chemistry - A European Journal

Cover image for Vol. 22 Issue 8

Editor: Neville Compton, Deputy Editors: Anne Deveson, Elisabeth Roedern

Impact Factor: 5.731

ISI Journal Citation Reports © Ranking: 2014: 22/157 (Chemistry Multidisciplinary)

Online ISSN: 1521-3765

Associated Title(s): Angewandte Chemie International Edition, Chemistry – An Asian Journal, ChemistryOpen, ChemistrySelect, ChemBioChem, ChemCatChem, ChemElectroChem, ChemMedChem, ChemPhysChem, ChemPlusChem, ChemSusChem, European Journal of Inorganic Chemistry, European Journal of Organic Chemistry

Cover Picture

06/2000The cover picture shows the computer-modeled ternary complex between the enzyme catechol O-methyltransferase (COMT) (yellow), Mg2+ (magenta), and a bisubstrate inhibitor (orange). The Conolly surface of the bisubstrate inhibitor is shown. Inhibition of COMT is an important approach for developing new therapeutic treatments in Parkinson's disease. For the first time a bisubstrate inhibitor for COMT was synthesized and its inhibition mechanism elucidated. This work is describe in more detail by F. Diederich et al. on p. 971ff.

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